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A bioactive peptide fragment derived from hemoglobin a 1 chain; exhibits potent vasoactive biological activity, reducing rat blood pressure over a dosage range of 0.1-10 μg/kg; also a potent central cannabinoid (CB1) receptor antagonist conferring analgesia and pain relief or antinociception in...
Source: Active recombinant N-terminal His-tagged SET7/9 purified from E. coli Mr: 43.3 kDa SET7/9 is exclusively a mono-methylase that methylates histone H3, tumor suppressor p53, and transcription factor TAF10. SET7/9 methylates p53 in response to DNA damage thereby activating p53 for subsequent...
Modified with a carboxylic acid group terminating the C-16 alkyl chain, providing a convenient site for chemical crosslinking.
(±)16-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
A naturally occurring reddish-yellow that is protective against a number of food-derived heterocyclic amines in bacterial mutagenicity assays through its inhibition of CYP450-dependent N-hydroxylation and reduction of N-hydroxylamines.
An anti-thrombotic agent which inhibits ADP-dependent platelet aggregation by selective and specific inhibition of cyclic nucleotide PDE3 (IC50 = 200 nM).
A full antagonist of RXR that demonstrates potent, nanomolar binding affinity; does not affect the corepressor interaction capacity of the RARα subunit in the RAR-RXR heterodimer configuration.
A cell-permeable, fluorescent dye that accumulates in acidic organelles in a pH-dependent manner and is used for autophagy detection and cell cycle determination; emits green fluorescence (ex. max: 502 nm; ,em. max: 525 nm) at neutral pH or when bound to dsDNA and red fluorescence (ex. max: 460 nm;...
A potent inhibitor of Cdk1 and Cdk2 (Kis = 9 and 6 nM; IC50s = 9.5 and 5.4 nM, respectively); 20 μM delays cell entry into mitosis and prevents proper cytokinesis, rendering binucleated cells with an abnormal number of centrosomes.
A stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis by cytoplasmic esterases; used in experiments to increase levels of intracellular α-ketoglutarate and modulate a variety of enzymes, particularly in the context of glycolysis, hypoxia, and cancer.
A cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM), blocking TNF-α-induced binding of TNF-α receptor I with TRADD and RIP1.
A selective, ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively; blocks the cell cycle, inhibits transcription, and induces apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 µM.
An antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor ET-1 to the ETA receptor in A10 cells at 0.1 μM; also inhibits VEGF-induced tube formation of HUVECs at 3-10 μM.
An internal standard for the quantification of LTE4 by GC- or LC-MS.
A potent, clinically-useful immunosuppressant; binds to FK-506 binding protein 12 (Ki = 0.2 nM) to inhibit calcineurin; regulates NO neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and IP3 receptors.
Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Arachidonic acid oxidizes spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Peroxide-free arachidonic acid is obtained after removal of the...
When measuring mitochondrial function or the effects of an unknown on mitochondrial function, it can be difficult to determine a mechanism using whole organisms or tissue. When this is the case, isolated mitochondria provide a simple and biochemically relevant experimental model. Cayman’s...
A prodrug of R406, an inhibitor of Syk (Ki = 30 nM); produces anti-inflammatory and immunomodulating effects by inhibiting Syk-mediated IgG Fcγ receptor signaling.
An internal standard for the quantification of trismethoxy resveratrol by GC- or LC-MS.
Antigen: human SET7/9 amino acids 131-145 and 336-352 Host: rabbit Cross Reactivity: (+) human and mouse SET7/9 Application(s): WB SET7/9 is a histone specific HMTase that methylates histone H3 lysine 4.
An orally active, long-acting antagonist of the TP receptor (IC50 = 16.4 nM); inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis.
A fluorophore that can be used as an indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DHR; used to investigate reactive oxygen intermediates produced by endothelial cells, eosinophils, and reactive microglia.
A phospholipid containing the medium-chain (12:0) lauric acid inserted at the sn-1 and sn-2 positions; commonly used in the generation of micelles, liposomes, and other types of artificial membranes.
An N-aryl tyrosine activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes; has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.