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A methyl ester analog of fluprostenol.
Source: Recombinant protein expressed in E. coli MW: 12.6 kDa
Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 39.89 kDa
OAG is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. OAG is metabolized to its corresponding phosphatidic acid (1-oleoyl-2-acetyl-3-phosphoglycerol), most likely through the action of a...
A competitive, irreversible inhibitor of Trx1; effective in suppressing the growth of cancer cells, with inhibition correlated with expression of Trx1 mRNA; reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM) and expression of VEGF and iNOS; reduces microvessel density...
A recombinant peptide that activates PAR-2 (EC50= ~5 µM), without requiring receptor cleavage; used to explore signaling through PAR2 in cells and in animals.
An aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM) without effect on SIRT1 or SIRT3-6; increases α-tubulin acetylation in HeLa cells.
A channel blocker which reversibly inhibits TRPA1 (IC50 = 3.1 and 4.5 µM, human and mouse, respectively); has minimal effect on TRPV1-4 or TRPM8.
Source: Recombinant protein expressed in E. coli MW: 13.72 kDa PLA2 (Type V) is a secretory PLA2 (sPLA2) that catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. It is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages...
A selective inhibitor of HER2/ErbB2 (IC50 = 10 nM); inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC50s = 0.25 and 0.95 μM, respectively) and demonstrates antitumor activity in various human tumor xenograft models.
A potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses (EC50 = 3.7 nM against the HBV in cultured 2.2.15 liver cells).
A potent inhibitor of ACAT2 (IC50 = 70 nM) with high selectivity over the ACAT1 isozyme (IC50 > 80 μM); 10-50 mg/kg per day for 12 weeks lowers plasma and hepatic cholesterol, VLDL, and LDL content in apolipoprotein E-knockout mice.
An allosteric inhibitor of oncogenic K-Ras(G12C); disrupts both switch-I and switch-II, altering the native nucleotide preference to favor GDP over GTP, which impedes binding to Raf.
A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM).
A selective PAM of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively; passes the blood-brain barrier to act centrally in rats.
Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 51.8 kDa
A thiol-reactive fluorogenic probe; used to evaluate or quantify a variety of compounds containing reactive sulfur or thiol groups, including H2S, glutathione, proteins, and nucleotides.
A novel ω-6 C20:2 fatty acid.
A compound used to attach biotin to primary amines, such as those found on lysines on the surface of proteins; contains six-atom spacer arm.
A synthetic intermediate useful for pharmaceutical synthesis.
An N-acylethanolamine that is produced endogenously from palmitoleic acid.
A small molecule that blocks phosphorylation of PPARγ by Cdk5 (IC50 = 80 nM; Ki = 28.7 nM) without exhibiting agonist activity at the PPARγ receptor; demonstrates potent, dose-dependent anti-diabetic effects in obese mice without inducing fluid retention and weight gain or inhibiting...
An internal standard for the quantification of (2S)-octyl-α-hydroxyglutarate by GC- or LC-MS.
A prodrug form of 5-azacytidine, an inhibitor of DNA methyltransferaes, that may reverse epigenetic changes.