Cayman Chemical

An oxysterol formed during the metabolic oxidation of cholesterol; used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser845 of GluR1 Host: rabbit Cross Reactivity: (+) rat GluR1 Application(s): IHC and WB The AMPAR are comprised of four distinct GluR subunits designated (GluR1-4), which play key roles in virtually all excitatory...

The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized TMPD at 590 nm. Inhibition of COX activity by a variety of selective and nonselective inhibitors shows...

A PAF receptor agonist with potency comparable to PAF C-18 and PAF C-16; chromogenic substrate used in Cayman’s PAF-AH Assay Kit (Item No. 760901).

A phospholipid containing the long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions.

An isoflavonoid phytoestrogenic compound found in soybeans, pea pods, and other legumes; acts as a tyrosine kinase inhibitor, has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors.

An activator of SIRT1 that decreases TNF-α levels from 325 pg/ml (control) to 104 and 53 pg/ml at 20 and 60 µM, respectively; exhibits a significant dose-dependent effect on fat mobilization in differentiated adipocytes.

.DELTA.2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. .DELTA.2-cis...

A potent inhibitor of ROCK-II and ROCK-I in enzyme and cell-based assays (IC₅₀s = 3 and 56 nM, respectively); efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.

A selective PPARα agonist (EC₅₀ = 20 µM) that has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia.

Ins(1,2,4,5,6)P5 (sodium salt) is one of several different inositol oligophosphate isomers implicated in signal transduction. In human Jurkat T-lymphocytes, as well as in cytosolic extracts from fetal calf thymus, Ins(1,2,4,5,6)P5 (sodium salt) is phosphorylated by a 1/3 kinase to InsP6.

A phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions.

Selectively inhibits checkpoint kinases Chk1 and Chk2 (IC50s = 5 nM); abrogates DNA damage-induced S and G2 checkpoints (EC50 = 10 nM) and potentiates the efficacy of gemcitabine and topotecan by modulating downstream checkpoint pathway proteins.

A competitive inhibitor of DNA ligases I, III, and IV (IC₅₀s = 5, 9, and 5 µM, respectively); blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.

A potent, selective, and time-dependent inhibitor of CYP3A4 (IC₅₀ = 30 nM).

Activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations; drives differentiation of human peripheral blood mononuclear cells, mobilized by G-CSF, toward a cardiac phenotype.

A dual inhibitor of mPGES-1 (IC₅₀ = 1.3 μM) and 5-LO (IC₅₀ = 1.0 μM); effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays.

A triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM); inhibits angiogenesis; has potential applications in various forms of cancer and pulmonary fibrosis.

A small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria; appears later than shorter acyl chain AHLs in developing biofilms; stimulates the production of putisolvin, which in turn, inhibits biofilm formation.

A saturated dialkyl glyceryl ether with octadecyl groups at the sn-1 and sn-2 positions, which mimics the structure of diacylglycerol.

A peptide antagonist of PAR2 which blocks activation by trypsin (IC₅₀ = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals.

An inhibitor of DPP-4 (IC₅₀ = 3.5-34 nM); also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or FAPα; blocks the degradation of several circulating peptides, including incretins; reduces fasting and postprandial glucose levels and decreases inflammatory...

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRβ. INDIGO’s reporter cells include the...

An antagonist of mGluR7, inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC₅₀ value of 88 nM; demonstrates good brain penetrance, producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests.