Cayman Chemical

A synthetic intermediate useful for pharmaceutical synthesis.

A sulfonate ester potentially genotoxic impurity found in active pharmaceutical ingredients.

Activates the aryl hydrocarbon receptor (Ki = 5.4 µM), inducing the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria; accelerates neutrophil apoptosis, resulting in resolution of acute inflammation.

The reduced form of the electron acceptor NADP+ and acts as an electron donor in various biological reactions.

An orally-available, highly selective inhibitor of B-RafV600E (IC₅₀ = 13 nM); less effective against wild type B-Raf (IC₅₀ = 160 nM) as well as several other kinases; induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf.

An isoxazole compound that inhibits Hsp90 with an IC₅₀ value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.

Oct4 is an essential regulator of embryonic stem cell pluripotency and used as a marker for undifferentiated cells. It also plays a role in gene expression, DNA repair and/or replication, signal transduction and tumorigenesis. Cayman’s Oct4 Transcription Factor Assay is a non-radioactive,...

A selective, irreversible antagonist of PPARβ/δ (pIC₅₀ = 6.6) that inhibits the expression of PPARβ/δ-regulated target genes, PDK4, CPT1a, and Angptl4.

An AM ester of the red fluorescent calcium indicator rhod-2; accumulates within mitochondria.

Reversibly binds tubulin and alters GTP hydrolysis as well as microtubule dynamics; nanomolar concentrations reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase; also used to induce the formation of Golgi ministacks in eukaryotic cells.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications.

A cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM.

An azo-compound that can be thermally decomposed in aqueous solution to generate superoxide radical anion at a constant, controlled rate; follows first order kinetics, and exhibits a half-life of 4,900 seconds at physiological pH and temperature.

An isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes.

Methotrexate-d3 is intended for use as an internal standard for the quantification of MTX (Item No. 13960) by GC- or LC-MS. MTX is similar in structure to folic acid (Item No. 20515) and aminopterin (Item No. 21802). It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the...

An α-galactoside of inositol that serves as a galactosyl donor in the transglycosidase-catalyzed biosynthesis of the raffinose family; generated from myo-inositol and uridine diphosphate galactose in a galactosyltransferase-catalyzed reaction.

A bacterial secondary metabolite which displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC₅₀ = 0.8 nM) and inducing apoptosis in endothelial cells; powerful inhibitor of both eukaryotic and bacterial threonyl tRNA synthetase; effective...

An irreversible inhibitor of mutant forms of EGFR including T790M (Ki = 21.5 nM) with minimal activity at the wild-type EGFR (Ki = 303.3 nM); inhibits the proliferation of NSCLC cells expressing mutant EGFR (GI50s = 7-32 nM) and demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and...

A sulfated bile acid that is used to induce pancreatic acinar cell injury in models of pancreatitis and to study bile acid transport.

A ketopentose synthesized in the pentose phosphate pathway that plays a role in the formation of various bioactive compounds.

The fibrate class of hypolipidemic drugs such as clofibrate and fenofibrate elicit their effects by binding to and activating peroxisome proliferator-activated receptor α (PPARα). Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity,...

A potent inhibitor of PKCβ (IC50 = 6 nM), with modest selectivity over PKCα, γ, and ε (IC50 = 39, 83, and 110 nM, respectively); at 3 µM, also inhibits signaling through the Akt pathway; suppresses angiogenesis, induces apoptosis, and reduces proliferation of cultured...

Glucose is stored in the muscles and liver as glycogen which is hydrolyzed to glucose and released into the blood when needed. The rate of glucose uptake in cells is dynamic and tightly regulated by hormones and/or growth factors. Cancer cells exhibit increased glucose uptake and metabolism by...