Cayman Chemical

A fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.

A potent, reversible, and selective inhibitor of Plk1 (Ki = 2.2 nM); dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis; effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.

A potent and selective inhibitor of PLD1, both in vitro (IC₅₀ = 46 nM) and in cells (IC₅₀ = 11 nM); also effective as a PLD2 inhibitor at higher concentrations (IC₅₀ = 933 nM in vitro; 1,800 nM in cells); strongly inhibits the invasive migration of several breast...

An analog of adenosine monophosphate that has antiviral activity; converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and HBV polymerase.

A 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria; inhibits NAT10.

A selective inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM).

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as that of the natural compound.

Antigen: human HMGB1 amino acids 100-150 Host: rabbit Cross Reactivity: (+) human, bovine, chicken, mouse, New World monkey, and rat HMGB1 Applications: FC, IHC (paraffin-embedded tissue), and WB HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated...

Antigen: human TX synthase amino acids 359-377 Host: rabbit Cross Reactivity: (+) human, mouse, porcine, and rat TX synthase Application(s): IHC and WB TX synthase catalyzes the conversion of PGH2 to TXA2, which is a potent vasoconstrictor and inducer of platelet aggregation.

AS-604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, .delta., β, and α isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21...

A form of arachidonic acid with an ω-terminal alkyne; can be used in click chemistry linking reactions to tag arachidonic acid as well as metabolites and derivatives.

A structural analog of the inhibitory neurotransmitter GABA that irreversibly inhibits its catabolism by GABA transaminase; produces a dose-dependent increase in extracellular GABA, and has been shown to result in increasing seizure suppression.

Antigen: human SPHK 1 amino acids 264-274 Host: rabbit Cross Reactivity: (+) human and mouse SPHK 1, expected to react with rat SPHK 1 Application(s): WB and ICC SPHK 1 catalyzes the phosphorylation of sphingosine to S1P. This reaction plays an important role in determining cell proliferation versus...

Source: Active recombinant N-terminal His-tagged enzyme amino acids 2-389 expressed in E. coli Mr: 44.2 kDa SIRT2 is a cytoplasmic protein responsible for the deacetylation of histone H4 and α-tubulin, a modification important for controlling the cell cycle. SIRT2 co-localizes with HDAC6 and...

An internal standard for the quantification of PEA by GC- or LC-MS.

Molecular Formula: C₁₃H₁₁ClNO₉ • Li

A DNA-binding, anti-tumor and neuroprotective antibiotic that mediates its protective function, in part, by inhibiting Sp1 transcription factor binding to oncogene promoters; at 10-200 nM can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many...

An anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively; displays chemopreventive activity in multiple tumor types via proapoptotic effects independent of its capacity to block COX-2.

A chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin; used for inhibitor screening and kinetic analysis.

A potent inhibitor of SK1 (IC₅₀ = 2-3.6 nM) that less effectively inhibits SK2 (IC₅₀ = 356 nM); prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC₅₀s = 8.4 and 27 nM, respectively); prevents sickling, hemolysis, and inflammation in...

Selective inhibitor of IDH1 R132H and R132C mutants in vitro (IC₅₀s = 0.07 and 0.16 µM, respectively) but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀s > 100 μM); anti-tumor efficacy in vitro and in vivo; induces demethylation of histone H3K9me3 and...

1,5-lactone of (±)5(6)-DiHET formed as an artifact during sample extraction.

A precursor of the vinblastine and vincristine group of alkaloids that have been used widely in chemotherapy regimens.

Oxidative stress in the cellular environment results in the formation of highly reactive and unstable lipid hydroperoxides. Decomposition of the unstable peroxides derived from polyunsaturated fatty acids results in the formation of malondialdehyde (MDA), which can be quantified colorimetrically...