Source: Active recombinant N-terminal His-tagged enzyme amino acids 2-389 expressed in E. coli
Mr: 44.2 kDa
SIRT2 is a cytoplasmic protein responsible for the deacetylation of histone H4 and α-tubulin, a modification important for controlling the cell cycle. SIRT2 co-localizes with HDAC6 and microtubules and functions as a mitotic checkpoint in preventing chromosomal instability that can lead to hyperploid cells.