Antigen: human PTEN amino acids 254-270
Host: rabbit
Cross Reactivity: (+) human, mouse, chimpanzee, canine, and rat PTEN
Application(s): WB and IHC (paraffin-embedded sections)
PTEN dephosphorylates proteins and lipids such as Akt and PIP3 and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is considered a tumor suppressor as loss-of-function mutations in PTEN often result in human cancers including melanoma and prostate carcinoma.