Biologically Active Small Molecules Products (6476)

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  • Tetrodotoxin Citrate

    Cayman Chemical
    Item #:
    C819Y79

    A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

  • LY294002

    Cayman Chemical
    Item #:
    C789F10-TS

    A selective PI3K inhibitor with an IC50 value of 1.4 µM.

  • Hoechst 33342 (hydrochloride)
    Item #:
    C818L78-TS

    A cell-permeable, fluorescent probe for DNA that is useful as a marker of nuclei for cell cycle studies in combination with BrdU and to distinguish nuclear morphology in apoptotic cells.

  • Palmitic Acid Alkyne

    Cayman Chemical
    Item #:
    C832W44-TS

    A form of palmitic acid with an ω-terminal alkyne for use in click chemistry to isolate palmitoylated proteins.

  • PP2

    Cayman Chemical
    Item #:
    C832U92-TS

    A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases: p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM).

  • SCH 79797 (hydrochloride)
    Item #:
    C823P83-TS

    A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively); has no activity against PAR2, PAR4, or other receptors involved in platelet...

  • Pargyline (hydrochloride)
    Item #:
    C835A13-TS

    Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The...

  • Bleomycin (sulfate)

    Cayman Chemical
    Item #:
    C830H17-TS

    A glycopeptide antitumor antibiotic that produces single and double-strand DNA breaks in tumor cells to interrupt their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of...

  • Tetrodotoxin

    Cayman Chemical
    Item #:
    C819Y78

    A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

  • TWS119

    Cayman Chemical
    Item #:
    C834G60-TS

    A potent inhibitor of GSK3β (IC50 = 30 nM) that induces neurogenesis in mouse embryonic stem cells.

  • MK-2206 (hydrochloride)
    Item #:
    C832F72-TS

    An orally active, allosteric Akt inhibitor (IC50s = 5, 12, and 65 nM for Akt1, 2, and 3, respectively); inhibits cell proliferation of human cancer cell lines synergistically in combination with other topoisomerase inhibitors, antimetabolites, antimicrotubule agents, DNA cross-linkers or growth...

  • Erastin

    Cayman Chemical
    Item #:
    C816Z63-TS

    An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml).

  • Imiquimod

    Cayman Chemical
    Item #:
    C819Y60-TS

    An imidazoquinoline compound that activates TLR7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC50 = 2 µM).

  • Epinastine (hydrochloride)
    Item #:
    C815F68-TS

    A non-sedating ophthalmic antihistamine that antagonizes histamine H1 receptors (IC50 = 1.58 nM) and prevents the release of pro-inflammatory mediators from mast cells and eosinophils.

  • 4-oxo-2-Nonenal

    Cayman Chemical
    Item #:
    C834U70-TS

    A lipid peroxidation product; actively modifies histidine and lysine residues on proteins and causes protein cross-linking.

  • Cinacalcet (hydrochloride)
    Item #:
    C817E98-TS

    A calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; pEC50 = 7.3 in HEK293T cells expressing CaSR) inhibiting parathyroid hormone secretion.

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