Biologically Active Small Molecules

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LKT Labs Biologically Active Small Molecules

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  • Butylated Hydroxytoluene

    LKT Labs

    Butylated hydroxytoluene (BHT) is commonly used as a food and cosmetics additive; it exhibits antioxidative and anti-inflammatory activities. BHT may also display neuroprotective benefit, decreasing ethanol-induced brain damage and neurodegeneration and suppressing activation of NF-?B activation…

  • A-type Natriuretic Peptide (1-28), rat

    LKT Labs

    Atrial natriuretic peptide (ANP) is a cardiomodulatory peptide that binds the natriuretic peptide receptor type A (NPR-A), increasing levels of cGMP and activating cGMP-dependent kinases. ANP exhibits vasodilatory/hypotensive, diuretic, and natriuretic activities, increasing perfusion and…

  • Caffeine

    LKT Labs

    Caffeine is a xanthine alkaloid found in coffee, tea, and many other plant sources; it exhibits stimulant, bronchodilatory, anti-asthma, vasoconstrictive, anti-inflammatory, antioxidative, anti-aging, and anti-fibrotic activities. Caffeine activates adenosine receptors and inhibits…

  • Adipokinetic Hormone II from Locusta migratoria

    LKT Labs

    A grasshopper neuropeptide from a family of arthropod hormones and neuroregulators, found in Locusta migratoria.

  • Chloramphenicol

    LKT Labs

    Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces.

  • Atriopeptin II, rat/rabbit/mouse

    LKT Labs

    Atriopeptin II is an analog of atrial natriuretic peptide (ANP) that exhibits vasodilatory/hypotensive and anxiolytic activities. Like other ANP analogs, atriopeptin II decreases blood pressure. This peptide also exhibits anxiety-lowering benefit in animals undergoing testing in the elevated plus maze.

  • Cetrimide

    LKT Labs

    Cetrimide is a mix of quaternary ammonium salts that exhibits antiseptic and anticancer chemotherapeutic activities. Cetrimide acts as a cationic detergent, altering the mitochondrial membrane potential and inducing pore formation in membranes. Cetrimide bromide inhibits H+ ATP synthase, inducing…

  • L-Arginine

    LKT Labs

    L-Arginine is an endogenous amino acid also found in meat, dairy, grains, and legumes. L-Arginine exhibits vasodilatory and antihypertensive activities, as it is a precursor to the formation of NO. L-Arginine decreases systolic and diastolic blood pressure, improving cardiovascular and endothelial…

  • Artemether

    LKT Labs

    Artemether is a sesquiterpene lactone derived from Artemisia. Artemisinins such as artemether are best known for their antimalarial activity. Artemether exhibits anti-parasitic activity against Plasmodium, Leishmania, and Schistosoma.

  • Ceramide

    LKT Labs

    Ceramide is an endogenous sphingosine and fatty acid-based waxy lipid; it is a component of sphingomyelin in the lipid bilayer of cells membranes. Ceramide is involved in signaling pathways for many cellular processes such as differentiation, proliferation, programmed cell death, and apoptosis.…

  • BMS-911543

    LKT Labs

    BMS-911543 is an oral selective inhibitor of JAK2 currently in clinical trials. BMS-911543 shows anticancer activity through inhibition of the JAK/STAT signaling cascade in in vitro and in vivo models of myeloproliferative neoplasms, which display constitutively active JAK2 signaling. This compound…

  • 5-Bromo-2'-Deoxyuridine

    LKT Labs

    5-Bromo-2’-deoxyuridine is a synthetic nucleoside analog of thymidine that is used in research models to label actively proliferating cells. This compound is incorporated into DNA but at low levels does not alter DNA replication. At high levels, this compound displays immunosuppressive activity and…

  • ß-Carotene

    LKT Labs

    ß-Carotene is a red-orange terpene pigment originally found in various plants and fruits; it is a prodrug for vitamin A. ß-Carotene exhibits antioxidative, cytoprotective, anticancer, anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. ß-Carotene is used in research models to…

  • n-Butyric Acid

    LKT Labs

    Butyric acid is a fatty acid found in many dairy products that exhibits anticancer activity. Butyric acid inhibits histone deacetylases (HDACs) and induces apoptosis and G1 phase cell cycle arrest in glioma cells. Additionally, butyric acid stimulates epithelial cell proliferation at low doses and…

  • Acetylsalicylic Acid

    LKT Labs

    NSAID and COX-1/2 inhibitor used to decrease inflammation. It inhibits platelet aggregation and prolongs bleeding time by decreasing levels of thromboxane A2. Chronic administration decreases risk of cancer and cardiovascular events.

  • Atropine

    LKT Labs

    Atropine is a tropane alkaloid found in plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activities. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for ophthalmic…

  • 4-bromo-A23187

    LKT Labs

    Non-fluorescent halogenated A23187 analog and Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acros

  • [Des-Arg9]-Bradykinin

    LKT Labs

    Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro,…

  • Azaperone

    LKT Labs

    Azaperone is a butyrophenone tranquilizer that exhibits sedative activity through the inhibition of a-adrenergic receptors. Azaperone also inhibits dopamine receptors and histamine receptors; it also may display antiemetic, antipsychotic, antihistaminergic, and anticholinergic activities.

  • Angiotensin Converting Enzyme Inhibitor Peptide

    LKT Labs

    This peptide is also known as bradykinin-potentiating peptide 9a; it exhibits vasodilatory and antihypertensive activity. This peptide inhibits angiotensin-converting enzyme (ACE) in vivo, decreasing blood pressure. This peptide also inhibits hydrolysis of bradykinin and inactivation of leutinizing…

  • AS-252424

    LKT Labs

    AS-252424 is an inhibitor of p110γ PI3K that exhibits anti-inflammatory activity. In animal models of peritoneal inflammation, AS-252424 decreases leukocyte recruitment. In vascular smooth muscle cells, AS-252424 decreases endothelin A receptor-mediated activity of transient receptor…

  • N-Acetyl-L-Cysteine

    LKT Labs

    N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose; it is occasionally commercially sold as a supplement. N-Acetyl-L-cysteine acts as a…

  • Bupivacaine

    LKT Labs

    Bupivacaine is an amino amide anesthetic that decreases current amplitude and inhibits whole cell K+ currents in Ca2+-activated (BK/SK) K+ channels and N-type voltage-gated (Kv1/shaker and Kv3 KCNA/KCNC) K+ channels. Bupivacaine also inhibits voltage-gated Na+ channels and tandem pore domain…

  • Calcitonin Gene Related Peptide (8-37), human

    LKT Labs

    Calcitonin gene-related peptide (CGRP) (8-37) inhibits the CGRP receptor and is used in research studies to examine the effects of CGRP. CGRP (8-37) inhibits the effects of ghrelin and induces caspase 3-mediated apoptosis in retinal cells of animal models of coronary artery occlusion. Like CGRP,…

  • Alloxan Monohydrate

    LKT Labs

    Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

  • Amoxicillin

    LKT Labs

    Amoxicillin is a ß-lactam penicillin antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria. Amoxicillin inhibits peptidoglycan polymerization through binding of penicillin binding proteins, inhibiting cell wall synthesis.

  • Cinnarizine

    LKT Labs

    Cinnarizine is an inhibitor of L-type voltage-gated Ca2+ channels that is clinically used to treat migraine and vertigo. Cinnarizine exhibits anticonvulsant/antiepileptic activity in combination with other therapies in animal models. This compound also inhibits D2 receptors, suppressing…

  • Carveol

    LKT Labs

    Carveol is a terpene alcohol initially found in spearmint oil that exhibits anti-parasitic, neuromodulatory, and anticancer activities. Carveol is commercially used as a food additive and fragrance. This compound activates transient receptor potential vanilloid 3 (TRPV3) channels in vitro and…

  • 5-Aza-2'-deoxycytidine

    LKT Labs

    ,p>Decitabine is a deoxycytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT1/3A/3B) activity. This demethylating agent is clinically used to treat myelodysplastic syndromes. Decitabine’s inhibition of DNA methyltransferase may be modulated by PKC. Decitabine…

  • ß-Amyloid Peptide (1-40), rat

    LKT Labs

    Amyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…

  • A-K-R-R-R-L-S-S-L-R-A

    LKT Labs

    This peptide is also known as S6 and is used as a phosphorylatable substrate for Rho-associated protein kinase 2 (ROCK-2).

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