Biologically Active Small Molecules

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LKT Labs Biologically Active Small Molecules

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  • Capecitabine

    LKT Labs

    Capecitabine is an antifolate anticancer chemotherapeutic that acts as a prodrug of 5-fluorouracil (5-FU), a fluoropyrimidine carbamate that inhibits thymidylate synthase. Capecitabine is converted to 5-FU by thymidine phosphorylase in vivo. Capecitabine displays varying efficacy in the treatment…

  • Dihydroartemisinin is a sesquiterpene lactone that can be derived from Artemisia. Dihydroartemisinin exhibits anticancer, antiviral, anti-inflammatory, anti-asthma, and anti-parasitic activities. Artemisinins such as dihydroartemisinin are best known for their antimalarial activity.…

  • 1,4-Benzoquinone

    LKT Labs

    1,4-Benzoquinone is a precursor used in the synthesis of hydroquinone and is also used as a hydrogen acceptor and oxidant. 1,4-Benzoquinone exhibits anti-inflammatory and antibiotic activities. 1,4-Benzoquinone inhibits 5-lipoxygenase and prevents leukotriene synthesis. Additionally, this compound…

  • Cambinol

    LKT Labs

    Cambinol is an inhibitor of sirtuins, particularly sirtuin1. Cambinol exhibits anti-inflammatory and anticancer chemotherapeutic activities. In various cell lines, cambinol suppresses MAPK and MEK signaling and inhibits expression of pro-inflammatory cytokines such as IL-1ß, IL-6, TNF-a, and…

  • Benzo[a]pyrene

    LKT Labs

    Benzo[a]pyrene is a polycyclic aromatic hydrocarbon (PAH) originally found in coal tar, cigarette smoke, and wood smoke. Metabolites of this compound bind DNA and induce mutations. Benzo[a]pyrene is highly carcinogenic and is used in research models to induce carcinogenesis and tumor formation.…

  • Aeruginosamide D

    LKT Labs

    Aeruginosamides are linear ribosomal peptides found in cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine proteases and protein phosphatases (PPs) or exhibit antithrombotic activity. Grade: ≥95%

  • Cisplatin

    LKT Labs

    Cisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a…

  • Actinomycin

    LKT Labs

    Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

  • Amphotericin B

    LKT Labs

    Amphotericin B is a polyene antifungal compound that increases levels of ROS and forms pores or channels in membranes by binding membrane sterols. Amphotericin B induces iNOS, activates astrocytes, and increases expression of IL-1ß, TNF-a, BDNF, and GDNF, displaying potential neuroprotective…

  • Butylated hydroxyanisole (BHA) exhibits antioxidative and anticancer activities. BHA is commercially used as a food additive or preservative, as its free radical scavenging ability stabilizes free radicals and prevents food spoilage. BHS also increases activity of superoxide dismutase (SOD) in…

  • Capsaicin is an agonist of transient receptor potential vanilloid (TRPV) channels that was originally found in peppers of the Capsicum genus. Capsaicin exhibits analgesic, anti-inflammatory, anti-obesity, and anticancer chemotherapeutic activity. Capsaicin also displays bronchoconstrictive activity…

  • Carvedilol phosphate is a cardioprotective a1- and ß1/2-adrenergic receptor inhibitor used to treat congestive heart failure; its inhibitory action at adrenergic receptors slows heart rhythm, decreasing force, pressure, and cardiac workload. Carvedilol phosphate also inhibits release of…

  • Artesunate

    LKT Labs

    Artesunate is a sesquiterpene lactone derived from Artemisia. Artesunate exhibits anticancer chemotherapeutic, antiviral, anti-angiogenic, and anti-parasitic activities. Artemisinins such as artesunate are best known for their antimalarial activity. Artesunate induces G0/G1 phase cell cycle arrest,…

  • (+)-Catechin

    LKT Labs

    Catechin is a flavanol originally found in Camilla and other plant sources; it exhibits antioxidative, anti-aging, anti-atherosclerotic, anti-ulcerative, neuroprotective, neuromodulatory, anticancer chemotherapeutic, and chemopreventive activities. Catechin increases life span in Caenorhabditis…

  • Aflatoxin M1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin M1 is the hydroxylated metabolite of aflatoxin B1; it inhibits DNA synthesis and induces cell cycle arrest.

  • Amylin, cat

    LKT Labs

    Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic ß-cells. Amylin is an endogenous peptide hormone that exhibits gastrointestinal motility modulating activity, decreasing gastric emptying and suppressing gastric acid secretion; these…

  • Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea. In clinical settings, ambroxol increases levels of thioredoxin and thioredoxin reductase, decreasing oxidative stress…

  • Aflatoxin B1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B1 is the most cytotoxic of all aflatoxins; it inhibits DNA synthesis and induces cell cycle arrest.

  • Angiotensin I (AT I) is a peptide cleavage product of angiotensin and served no primary biological purpose other than to function as a precursor to angiotensin II.

  • Cholesterol

    LKT Labs

    Cholesterol is a sterol component of animal cell membranes that is required for membrane fluidity. Cholesterol is also the precursor to most steroid hormones, bile acids, and vitamin D compounds. Additionally, cholesterol is involved in vesicular transport and nerve conduction, and shows some…

  • Biotin

    LKT Labs

    Biotin is a water-soluble B vitamin (vitamin B7) that may be found in many foods but is also administered as a dietary supplement. Biotin is a coenzyme involved in the synthesis of fatty acids, isoleucine, and valine; it also plays a role in gluconeogenesis. Biotin may be found attached to lysine…

  • Atosiban Acetate

    LKT Labs

    Atosiban is an antagonist at oxytocin and vasopressin receptors, exhibiting tocolytic activity. Atosiban is clinically used to decrease uterine contractility in the prevention of preterm birth.

  • Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally,…

  • Aspartame

    LKT Labs

    Aspartame is a dipeptide ester that is used as an artificial sweetener in commercial food production. Aspartame exhibits antibacterial efficacy against Porphyromonas, a periodontal pathogen. In vivo, aspartame also displays antinociceptive activity, increasing latency times in tail flick and paw…

  • Aflatoxin M2

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin M2 is the hydroxylated metabolite of aflatoxin B2; it inhibits DNA synthesis and induces cell cycle arrest.

  • Bis(3,5-dibromosalicyl) fumarate is an aspirin analog that is used to induce hemoglobin chain crosslinks at lysine residues. This compound is used to study hemoglobin function in research models and may be used to develop treatments for sickle-cell anemia. This compound may exhibit…

  • A grasshopper neuropeptide from a family of arthropod hormones and neuroregulators, found in Locusta migratoria.

  • This peptide is secreted by Agkistrodon vipers and inhibits activity of angiotensin-converting enzyme (ACE) and bradykinin inhibiting peptidases. Grade: ≥95%

  • This product is used to measure apoptosis in vitro.

  • Aconitine

    LKT Labs

    Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis.…

  • L-Carnitine

    LKT Labs

    L-Carnitine is an endogenous quaternary ammonium compound required for fatty acid transport; it is often given as a dietary supplement. The L-isomer is active, exhibiting anti-osteoporotic, antioxidative, and cardioprotective activities. In a clinical setting, L-carnitine administration increases…

  • Cafestol

    LKT Labs

    Cafestol is a diterpene found in brewed, unfiltered coffee that exhibits anti-angiogenic, anticancer, chemopreventive, neuromodulatory, anti-inflammatory, and hyperlipidemic activities. Cafestol inhibits proliferation, migration, and tube formation in vitro, potentially through decreasing…

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