Biologically Active Small Molecules

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LKT Labs Biologically Active Small Molecules

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  • Anabaenopeptin 872

    LKT Labs

    Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases.…

  • 1,4-Benzoquinone

    LKT Labs

    1,4-Benzoquinone is a precursor used in the synthesis of hydroquinone and is also used as a hydrogen acceptor and oxidant. 1,4-Benzoquinone exhibits anti-inflammatory and antibiotic activities. 1,4-Benzoquinone inhibits 5-lipoxygenase and prevents leukotriene synthesis. Additionally, this compound…

  • Calcitonin, human

    LKT Labs

    Calcitonin is an endogenous neuropeptide that exhibits pro-oncogenic, anti-osteoarthritic, and anti-resorptive activities. Calcitonin induces activation of NF-?B, upregulating expression and activity of fibronectin, MMP-1, MMP-2, and MMP-9 and increasing cell growth in osteosarcoma cells. When…

  • Brain Injury-derived Neurotrophic Peptide (3)

    LKT Labs

    This peptide supports neuronal survival and protects neurons in glutamate-induced cell death assays.

  • Ac-DEVD-pNA

    LKT Labs

    This peptide is a substrate for caspase 3 and is used to measure caspase 3 activation. Grade: ≥95%

  • Cefaclor Monohydrate

    LKT Labs

    Cefaclor is a second generation β-lactam cephalosporin antibiotic. Cefaclor exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefaclor also displays…

  • Balofloxacin Dihydrate

    LKT Labs

    Balofloxacin is a fluoroquinolone antibiotic that displays strong antibacterial activity against gram-positive bacteria and weak antibacterial activity against gram-negative bacteria. Balofloxacin inhibits the supercoiling ability of bacterial DNA gyrase, and shows efficacy treating early and…

  • Arenobufagin

    LKT Labs

    Arenobufagin is a bufanolide steroid found in the Argentine toad Bufo arenarum. This compound exhibits anticancer chemotherapeutic and anti-angiogenic properties, but is also cardiotoxic, inhibiting cardiovascular Na+/K+ pumps. In cellular models, arenobufagin induces autophagy and apoptosis,…

  • Azathioprine

    LKT Labs

    Azathioprine is a purine analog that acts as a prodrug of mercaptopurine. Azathioprine exhibits anticancer chemotherapeutic, immunosuppressive, and antiviral activities. Azathioprine inhibits amidophosphoribosyl transferase, inhibiting the production of adenine and guanine purines and preventing…

  • Annexin V-FITC Apoptosis Detection Kit

    LKT Labs

    This product is used to measure apoptosis in vitro.

  • Alloxan Monohydrate

    LKT Labs

    Alloxan is an oxygenated pyrimidine and toxic analog of glucose. Alloxan destroys ß cells and is used in research models to induce diabetes. This compound does not affect human cells.

  • Carboplatin

    LKT Labs

    Carboplatin is a platinum-based cross-linking agent that exhibits immunomodulatory and anticancer chemotherapeutic activities. Carboplatin binds DNA with slower kinetics than other platinum drugs, inhibiting DNA transcription and replication; it is clinically used to treat various cancers.…

  • BI-2536

    LKT Labs

    BI-2536 is a polo-like kinase 1 (PLK1) inhibitor that disrupts mitosis and cell division. BI-2536 exhibits anticancer activity and may induce apoptosis in cancer cells.

  • ß-Amyloid Peptide (1-42), rat

    LKT Labs

    Amyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…

  • ALAL

    LKT Labs

    ALAL is a peptide sequence commonly used as a linker to conjugate compounds together to better target delivery of anticancer chemotherapeutics. Grade: ≥95%

  • Adapalene

    LKT Labs

    Adapalene is a derivative of tretinoin that is clinically used to treat acne and pityriasis versicolor. This synthetic retinoid exhibits anti-inflammatory activity, decreasing expression of Ki67, a2-integrin, a6-integrin, toll-like receptor 2 (TLR2), IL-8, and ß-defensin in ex vivo models. Like…

  • Bicalutamide

    LKT Labs

    Bicalutimide is an inhibitor of the androgen receptor that exhibits anticancer chemotherapeutic activity. With other anti-androgens, bicalutimide decreases levels of Bcl-2, Bcl-XL, caspase-3, and PARP, induces apoptosis, and inhibits cell growth of prostate cancer cells. In similar animal models,…

  • Biotin

    LKT Labs

    Biotin is a water-soluble B vitamin (vitamin B7) that may be found in many foods but is also administered as a dietary supplement. Biotin is a coenzyme involved in the synthesis of fatty acids, isoleucine, and valine; it also plays a role in gluconeogenesis. Biotin may be found attached to lysine…

  • ASP3026

    LKT Labs

    ASP-3026 inhibits anaplastic lymphoma kinase (ALK) and shows anticancer chemotherapeutic activity. Treatment with ASP-3026 lowers tumor burden in lung and intrapleural tumor models.

  • Bongkrekic Acid

    LKT Labs

    Bongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress. Grade: ≥98%

  • Cisplatin

    LKT Labs

    Cisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a…

  • Atosiban Acetate

    LKT Labs

    Atosiban is an antagonist at oxytocin and vasopressin receptors, exhibiting tocolytic activity. Atosiban is clinically used to decrease uterine contractility in the prevention of preterm birth.

  • Anabaenopeptin F

    LKT Labs

    Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases.…

  • Abiraterone

    LKT Labs

    Progesterone derivative and Cyp17A1 inhibitor used to treat castration-resistant prostate cancer. It decreases androgen production and may inhibit eIF4F signaling.

  • Cinacalcet Hydrochloride

    LKT Labs

    Cinacalcet is an agonist at Ca2+-sensing receptors that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. This compound decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, and lowers…

  • Chlorpromazine Hydrochloride

    LKT Labs

    Chlorpromazine is a phenothiazine that exhibits antipsychotic, antidepressant, anxiolytic, neuroprotective, and anticancer chemotherapeutic activities. Chlorpromazine inhibits D1/2/3/4 receptors, 5-HT1/2 receptors, a1/2-adrenergic receptors, and M1/2 muscarinic acetylcholine receptors (mAChRs).…

  • Cafestol Acetate

    LKT Labs

    Cafestol is a diterpene initially found in brewed, unfiltered coffee that exhibits anti-angiogenic, anticancer, chemopreventive, neuromodulatory, anti-inflammatory, and hyperlipidemic activities. Cafestol inhibits proliferation, migration, and tube formation in vitro, potentially through decreasing…

  • Allicin

    LKT Labs

    Allicin is an thiocyanate found in garlic; it exhibits a wide variety of properties, including anticancer, antioxidative, antihypertensive, anti-arrhythmic, anti-parasitic, and anti-diabetic activities. In vitro, allicin binds cellular nucleic acid, primarily nitrogenous bases and phosphate…

  • L-Arginine

    LKT Labs

    L-Arginine is an endogenous amino acid also found in meat, dairy, grains, and legumes. L-Arginine exhibits vasodilatory and antihypertensive activities, as it is a precursor to the formation of NO. L-Arginine decreases systolic and diastolic blood pressure, improving cardiovascular and endothelial…

  • Busulfan

    LKT Labs

    Busulfan is an alkyl sulfonate that exhibits anticancer chemotherapeutic activity. Busulfan is an alkylating agent that attaches an alkyl group to the N7 position of guanine bases, inhibiting DNA replication; it is clinically used to treat chronic myelogenous leukemia (CML). In vitro, busulfan…

  • L-Alaninol

    LKT Labs

    L-Alaninol is an amino acid alcohol that exhibits anticancer activity. L-Alaninol inhibits proliferation of melanoma cells and increases levels of cytochrome c reductase and tau-glutamyl transpeptidase. Grade: ≥98%

  • CEF6

    LKT Labs

    CEF peptides are v-Src-induced cytokines from chicken embryo fibroblasts. These peptides are biomarkers of CEF transformation by Rous sarcoma virus. Grade: ≥95%

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