Biologically Active Small Molecules

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LKT Labs Biologically Active Small Molecules

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  • CEF3

    LKT Labs

    CEF peptides are v-Src-induced cytokines from chicken embryo fibroblasts. These peptides are biomarkers of CEF transformation by Rous sarcoma virus. Grade: ≥95%

  • Acepromazine Maleate

    LKT Labs

  • Berteroin

    LKT Labs

    Berteroin is a Erucin homolog that may exhibit antioxidative and anti-androgenic activities. Berteroin is an isothiocyanate (ITC) compound that decreases androgen receptor levels in prostate cancer cells. Berteroin also displays anti-inflammatory properties, decreasing LPS-induced release of…

  • Mechlorethamine Hydrochloride

    LKT Labs

    Mechlorethamine is a nitrogen mustard DNA alkylator that binds and alkylates the N7 nitrogen on guanine and adenine bases in DNA. Mechlorethamine was initially developed as a blistering agent for use in chemical warfare but has since exhibited anticancer chemotherapeutic benefit. In vitro and in…

  • Bombesin

    LKT Labs

    Bombesin is a gastrin-releasing peptide (GRP) analog that stimulates intestinal function; it was originally found in Bombina toads and binds bombesin receptors (BBRs) and GRP receptors. Mammalian homologs of this compound are neuromedin B and GRP. Bombesin exhibits antiepileptic/anticonvulsant…

  • Anisodamine

    LKT Labs

    Anisodamine is a tropane alkaloid originally found in plants in the Solanaceae family; it exhibits anti-inflammatory activity and is clinically used to induce atropinization in organophosphate poisoning subjects and to improve acute lung injury pathology and respiratory parameters. Anisodamine…

  • CEP-32496

    LKT Labs

    CEP-32496 is a kinase inhibitor that has multikinase binding activity but remains selectively cytotoxic for mutant (V600E) B-Raf (versus WT); it exhibits anticancer chemotherapeutic activity. Also contributing to the ability of CEP-32496 to inhibit cell proliferation, this compound inhibits pMEK…

  • Calcineurin Autoinhibitory Peptide

    LKT Labs

    This peptide inhibits calcineurin phosphatase activity and is used to examine the effects of calcineurin in research studies. In cellular models, this peptide inhibits calcineurin-induced glutamate-mediated neuronal cell death and decreases L-type Ca2+ channel currents. Grade: ≥95%

  • Brevetoxin 3

    LKT Labs

    Brevetoxins are lipid-soluble polyether neurotoxins initially produced by the dinoflagellate Karenia brevis. Brevetoxins act as agonists, binding the neurotoxin site 5 on SCN4A/Nav1.4 and SCN5A/Nav1.5 voltage-gated Na+ channels in skeletal muscle and cardiac tissue, producing a channel opening…

  • Asiatic Acid, 95%

    LKT Labs

    Asiatic acid is a triterpene aglycone originally found in Centella; it exhibits cardioprotective, hepatoprotective, anti-inflammatory, antioxidative, antihypertensive, anticancer, anti-fibrotic, and anti-osteoporotic activities. In vitro and in vivo, asiatic acid inhibits TGF-β1-induced and…

  • Cafestol Acetate

    LKT Labs

    Cafestol is a diterpene initially found in brewed, unfiltered coffee that exhibits anti-angiogenic, anticancer, chemopreventive, neuromodulatory, anti-inflammatory, and hyperlipidemic activities. Cafestol inhibits proliferation, migration, and tube formation in vitro, potentially through decreasing…

  • Argatroban

    LKT Labs

    Argatroban is an antithrombotic/anticoagulant compound that inhibits thrombin. Argatroban is clinically used to treat thrombosis and acute coronary syndrome.

  • Amphotericin B

    LKT Labs

    Amphotericin B is a polyene antifungal compound that increases levels of ROS and forms pores or channels in membranes by binding membrane sterols. Amphotericin B induces iNOS, activates astrocytes, and increases expression of IL-1ß, TNF-a, BDNF, and GDNF, displaying potential neuroprotective…

  • Aflatoxin B1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B1 is the most cytotoxic of all aflatoxins; it inhibits DNA synthesis and induces cell cycle arrest.

  • Atosiban Acetate

    LKT Labs

    Atosiban is an antagonist at oxytocin and vasopressin receptors, exhibiting tocolytic activity. Atosiban is clinically used to decrease uterine contractility in the prevention of preterm birth.

  • ß-Amyloid Peptide (1-42), human

    LKT Labs

    Amyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…

  • B-type Natriuretic Peptide (1-32), rat

    LKT Labs

    Brain natriuretic peptide (BNP) binds the natriuretic peptide receptor type B (NPR-B) to exert cardiomodulatory activity. BNP is secreted by the heart; it displays lipolytic effects, contributing to fatty acid mobilization in congestive heart failure. High levels of BNP are predictive of…

  • Aflatoxin B2

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B2 is cytotoxic; it inhibits DNA synthesis and induces cell cycle arrest.

  • Chlorpheniramine Maleate

    LKT Labs

    Chlorpheniramine is a first generation alkylamine antihistamine that inhibits H1 histamine receptors, serotonin transporters (SERT), and norepinephrine transporters (NET); it exhibits anti-allergic and antidepressant activities. Chlorpheniramine is clinically used to treat allergic rhinitis and…

  • Clodronate Disodium Tetrahydrate

    LKT Labs

    Clodronate is a first-generation non-nitrogen-containing bisphosphonate that is used clinically for its anti-resorptive activity. Clodronate generates formation of a non-hydrolysable ß-? ATP analog that inhibits mitochondrial ADP/ATP translocase and prevents mitochondrial oxygen consumption…

  • 17-Allylaminogeldanamycin

    LKT Labs

    Geldanamycin derivative and HSP90 inhibitor. It induces apoptosis in cancer cells and inhibits replication of cytomegalovirus.

  • 1,4-Benzoquinone

    LKT Labs

    1,4-Benzoquinone is a precursor used in the synthesis of hydroquinone and is also used as a hydrogen acceptor and oxidant. 1,4-Benzoquinone exhibits anti-inflammatory and antibiotic activities. 1,4-Benzoquinone inhibits 5-lipoxygenase and prevents leukotriene synthesis. Additionally, this compound…

  • AGDV

    LKT Labs

    AGDV is a C-terminal peptide sequence found on fibrinogen that is known as a binding site for glycoprotein IIb/IIIa (integrin aIIbß3); this binding is required for platelet adhesion and aggregation.

  • Caspofungin Diacetate

    LKT Labs

    Caspofungin acetate is a lipopeptide antifungal that inhibits the enzyme 1,3-ß-Glucan synthase, which synthesizes ß-glucan polymers that form fungal cell walls. Caspofungin acetate is active against a variety of Aspergillus and Candida species and unlike many antifungals, is not metabolized by the…

  • Betamethasone Valerate

    LKT Labs

    Betamethasone valerate (BMV) is a synthetic glucocorticoid that is commonly used to treat psoriasis and dermatitis. BMV exhibits immunomodulatory, anti-inflammatory, and vasoconstrictive activity in vitro and in vivo. Across animal models of varying ages, BMV impairs maturation and viability of…

  • Antipain Dihydrochloride

    LKT Labs

    Antipain is an oligopeptide first produced by Actinomycetes that inhibits proteases such as trypsin and papain. Grade: ≥98%

  • Asparaginase

    LKT Labs

    Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartate and ammonia, depleting asparagine levels and inhibiting cell growth; it is commonly used as an anticancer chemotherapeutic and anti-angiogenic compound in the treatment of leukemia. Asparaginase inhibits…

  • Deoxyandrographolide

    LKT Labs

    Deoxyandrographolide is a labdane diterpenoid found in Andrographis. This compound is an isoprenoid that inhibits PAF in neutrophils. Deoxyandrographolide exhibits antioxidative, vasodilatory, and hepatoprotective activities. This compound activates cNOS and adenylyl cyclase, decreasing oxidative…

  • a-Calcitonin Gene Related Peptide, chicken

    LKT Labs

    Calcitonin gene-related peptide (CGRP) is an endogenous neuropeptide that exhibits anti-inflammatory, anti-resorptive, anxiogenic, neuroprotective, and pro-angiogenic activities. In animal models of livery injury, CGRP displays protective benefit, decreasing pro-inflammatory cytokine levels. CGRP…

  • Cefotaxime Sodium

    LKT Labs

    Cefotaxime is a third generation β-lactam cephalosporin antibiotic. Cefotaxime exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefotaxime is also…

  • Aminophylline Anhydrous

    LKT Labs

    Aminophylline is a non-selective adenosine receptor antagonist and phosphodiesterase (PDE) inhibitor. Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced…

  • [Des-Asp1]-Angiotensin I, Human

    LKT Labs

    Angiotensin I (AT I) is a peptide cleavage product of angiotensin and serves no primary biological purpose other than to function as a precursor to angiotensin II.

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