Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Cu-ATSM

    Cayman Chemical

    An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue; improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to cells in the spinal cords of mice to prevent…

  • Auraptene

    Cayman Chemical

    A coumarin derived from citrus plants with anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities; inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.

  • Skepinone-L

    Cayman Chemical

    An ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 µM); has little effect on a range of other kinases, including p38γ and p38δ; blocks the phosphorylation of HSP27, a p38 MAPK substrate, in response to…

  • NDMC101

    Cayman Chemical

    Molecular Formula: C13H9ClFNO2

  • 6(S)-Lipoxin A4

    Cayman Chemical

    The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. LXA4 was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S);…

  • 7-Methylguanosine

    Cayman Chemical

    A purine base modified by the addition of a methyl group that is used as a biomarker for some types of cancer; closely resembles the 5’ terminal cap structure present on eukaryotic mRNA.

  • 13-Docosenamide

    Cayman Chemical

    An amide of docosenoic acid first identified in the CSF of sleep-deprived cats; causes reduced mobility and slightly lessened awareness in rats.

  • Streptozotocin

    Cayman Chemical

    A glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • Y-27632 (hydrochloride)

    Cayman Chemical

    A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM.

  • Acetaminophen

    Cayman Chemical

    An analgesic and antipyretic compound; inhibits COX-2 activity by more than 80%, albeit at relatively high doses, while it is less effective against COX-1.

  • WYE-354

    Cayman Chemical

    A selective, potent, and cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTORC1 and mTORC2; induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and reduces tumor growth in nude mice with PTEN-null tumors.

  • 2-NBDG

    Cayman Chemical

    A fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues; also used as a topical contrast reagent for the detection of neoplasia.

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • Natamycin

    Cayman Chemical

    A naturally occurring macrolide polyene used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium (minimal inhibitory concentrations ~ 4-64 μM); also used in the food industry as a "natural" preservative.

  • Tetrodotoxin Citrate

    Cayman Chemical

    A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

  • A competitive inhibitor of 15-hydroxy PGDH; acts as an agonist on most EP receptor subtypes (Kd d~ 1 nM for isolated EP2 receptors); preserves the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.

  • Coomassie Blue R-250

    Cayman Chemical

    A dye that is commonly used in laboratories to stain or quantify proteins; typically gives blue bands on a clear background with a sensitivity of 50-100 ng/band; displays metachromasia by appearing pink-red, rather than blue, when binding certain proteins, such as collagen and histone H1.

  • Torin 1

    Cayman Chemical

    A potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively); efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.

  • N-Palmitoyl Glycine

    Cayman Chemical

    An 18-carbon saturated fatty acid that is structurally similar to the phospholipid-derived N-acyl ethanolamines; inhibits heat-induced firing of nociceptive neurons in rat dorsal horn; induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-sensitive, DRG-like…

  • Rotenone

    Cayman Chemical

    A classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively; used in animal models of Parkinson’s disease.

  • An H2S donor commonly used in cellular and whole animal experimental systems.

  • Ethyl palmitoleate is a more lipophilic form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol. Ethyl palmitoleate (10-100 µM) in addition to 850 mM ethanol…

  • Aprepitant

    Cayman Chemical

    An antiemetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC50 = 0.09 nM for hNK1).

  • Aconitine

    LKT Labs

    Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis.…

  • Fludarabine

    Cayman Chemical

    A nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.

  • Caffeine

    LKT Labs

    Caffeine is a xanthine alkaloid found in coffee, tea, and many other plant sources; it exhibits stimulant, bronchodilatory, anti-asthma, vasoconstrictive, anti-inflammatory, antioxidative, anti-aging, and anti-fibrotic activities. Caffeine activates adenosine receptors and inhibits…

  • SR8278

    Cayman Chemical

    An antagonist of REV-ERBα (EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112; stimulates the expression of the REV-ERBα target genes G6Pase and PEPCK in liver cells; used to elucidate the role of REV-ERBα in regulating glucagon…

  • Hydrocortisone-21-Acetate

    MP Biomedicals

    Hydrocortisone 21 acetate is a drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate,…

  • Triton X-100 (20% v/v) stock solution contains 20% Triton X-100. It is ready to use as supplied.

  • TCEP (hydrochloride)

    Cayman Chemical

    An odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications; commonly used to rapidly reduce protein and peptide disulfide bonds.

  • A fluoroquinolone antibiotic that is administered either orally or parenterally.

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