Biologically Active Small Molecules

Compare Tool

Select up to 3 products

HomeAll Products

Biologically Active Small Molecules

1 - 32 of 6493
Sort
View
Show
  • Ochratoxin A

    Cayman Chemical

    A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…

  • Pentylenetetrazole

    Cayman Chemical

    A central nervous system modulator that is used to experimentally induce seizures in animals; used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.

  • Oleic Acid ethyl ester

    Cayman Chemical

    Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid.

  • Nourseothricin (sulfate)

    Cayman Chemical

    A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells.

  • 2-D08

    Cayman Chemical

    An inhibitor of sumoylation.

  • 24-dehydro Cholesterol

    Cayman Chemical

    An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis; reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.

  • GSK5959

    Cayman Chemical

    A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

  • CAY10566

    Cayman Chemical

    A potent, selective inhibitor of Stearoyl-CoA desaturase 1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.

  • Fluo-3 (ammonium salt)

    Cayman Chemical

    A fluorescent calcium indicator commonly used in FC and cell-based experiments to detect changes in intracellular calcium levels.

  • Pyrimethamine

    Cayman Chemical

    A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models.

  • Capecitabine

    LKT Labs

    Capecitabine is an antifolate anticancer chemotherapeutic that acts as a prodrug of 5-fluorouracil (5-FU), a fluoropyrimidine carbamate that inhibits thymidylate synthase. Capecitabine is converted to 5-FU by thymidine phosphorylase in vivo. Capecitabine displays varying efficacy in the treatment…

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • X-Gal

    Cayman Chemical

    A cell-permeable, chromogenic substrate for β-galactosidase used in histochemical and molecular biology applications, including detection of lacZ activity in cells and tissues.

  • CBL0137

    Cayman Chemical

    A water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM; has broad anticancer activity in mice when administered orally.

  • 3-Acetyldeoxy Nivalenol

    Cayman Chemical

    A trichothecene mycotoxin that can be converted to DON in the body.

  • Dihydroartemisinin is a sesquiterpene lactone that can be derived from Artemisia. Dihydroartemisinin exhibits anticancer, antiviral, anti-inflammatory, anti-asthma, and anti-parasitic activities. Artemisinins such as dihydroartemisinin are best known for their antimalarial activity.…

  • Aflatoxin G1

    Cayman Chemical

    A food contaminant produced by Aspergillus that is associated with toxicity and hepatocarcinogenicity in human and animal populations.

  • 1,2-Dioleoyl-sn-glycerol

    Cayman Chemical

    An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm.

  • Mifepristone

    Cayman Chemical

    A potent PR and GR antagonist with Ki value of approximately 1 nM.

  • Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 6-Oxo-3,5,-diol is a major metabolite of cholesterol formed…

  • FTY720 (S)-Phosphate

    Cayman Chemical

    Single stereoisomer of FTY720-phosphate formed in vivo; exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, which are 5-130-fold lower than those observed for the FTY720 (R)-phosphate

  • A coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways; binds the FMN riboswitch (RFN element) on RNA to alter gene regulation; a substrate of FMN phosphohydrolases.

  • U-0126

    Cayman Chemical

    A selective MAP Kinase Kinase (MKK, MEK) inhibitor with IC50 values of 72 and 58 nM for MEK1 and MEK2, respectively.

  • Doxorubicin (hydrochloride)

    Cayman Chemical

    An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA.

  • PAF C-16 Carboxylic Acid

    Cayman Chemical

    Modified with a carboxylic acid group terminating the C-16 alkyl chain, providing a convenient site for chemical crosslinking.

  • Tris-HCl Stock Solution (1 M, pH 7.5) contains filtered Tris-HCl (1 M, pH 7.5). It is ready to use as supplied.

  • 3-Thiatetradecanoic Acid

    Cayman Chemical

    3-thia TDA is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage. When chronically administered to rats, 3-thia TDA acts as a peroxisome inducer (PPAR ligand), increases fatty acid oxidation, and lowers plasma…

  • DuP-697

    Cayman Chemical

    DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the…

  • A fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans.

  • 5a-Androst-16-en-3-one

    Cayman Chemical

    A mammalian pheromone used to prime sexual behavior of sows in estrus for mating or artificial insemination; also used to study receptor-mediated odorant detection and the genetic basis for anosmias.

  • 15(R)-Prostaglandin E2

    Cayman Chemical

    15(R)-PGE2 is the C-15 epimer of the naturally occurring 15(S)-PGE2. 15(R)-PGE2 is much less potent than the natural stereoisomer in most biological assays. In hamsters, a dose of 0.20 mg of PGE2 inhibits fertility by 100%, whereas a dose of 1.0 mg of 15(R)-PGE2 inhibits fertility by only 17%.…

  • C646

    Cayman Chemical

    An inhibitor of the HAT p300 (IC50 = 1.6 μM); competitively binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases; blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro.

Compare Tool

Select up to 3 products

Please Log In

Don't have a web profile? Create one now.