Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Stearic Acid

    Cayman Chemical

    A long-chain saturated fatty acid that does not affect plasma total cholesterol or LDL-cholesterol but may reduce HDL-cholesterol.

  • (±)-Enterolactone

    Cayman Chemical

    Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human serum. Enterolactone and other ligans and…

  • 10-OAHSA

    Cayman Chemical

    A FAHFA in which oleic acid is esterified to 10-hydroxy stearic acid.

  • Ruthenium Red

    Cayman Chemical

    A polycationic dye that inhibits sarcoplasmic reticulum Ca2+ release, blocks Ca2+ uptake and release from mitochondria, and prevents Ca2+ release from ryanodine-sensitive intracellular stores in skeletal and cardiac muscle (Kis = 16 nm - 5.9 μM, depending on Ca2+ concentration).

  • a-Cembrenediol

    LKT Labs

    Cembrenediols are diterpenes originally found in Anisomeles. These compounds exhibit antibacterial activity against Mycobacterium and antifungal activity against Colletotrichum. Grade: ≥98%

  • Honokiol

    Cayman Chemical

    A natural product with diverse therapeutic effects, including acting as an anxiolytic in mice; inhibits NF-κB and PI3K/Akt signaling, preventing inflammation; interferes with angiogenesis while preventing tumor growth in vivo; scavenges superoxide and peroxyl radicals.

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • Celiprolol (hydrochloride)

    Cayman Chemical

    A β1 adrenergic receptor antagonist and a β2 adrenergic receptor partial agonist that relaxes human arteries and veins with ED50 values of 40-50 µM in vitro; reduces myocardial infarct size and increases NO production in a rabbit model of myocardial ischemia at 1-10 mg/kg/h.

  • Sotalol (hydrochloride)

    Cayman Chemical

    A non-selective antagonist of β-adrenergic receptors that blocks β1-, β2-, and β3-adrenoceptors with IC50 values ranging between 0.1 and 8.9 µM; also blocks outward potassium currents in myocardium, exhibiting Class III antiarrhythmic actions.

  • DPPH

    Cayman Chemical

    A cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant activity of tissue extracts; followed by color change from purple (absorbance at 515-528 nm) to yellow.

  • Docosanoyl Ethanolamide

    Cayman Chemical

    A saturated N-acylethanolamide whose non-CB receptor-mediated pharmacology is still being elucidated; may have a role in the functioning of ion channels.

  • Decanoyl m-Nitroaniline

    Cayman Chemical

    One of several nitroaniline fatty acid amides that can be used to measure FAAH activity; exposure to FAAH results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) allowing for fast and convenient measurement of FAAH activity using a 96-well plate spectrophotometer.

  • Tigecycline

    Cayman Chemical

    A glycylcycline antibiotic with a broad spectrum of activity against many Gram-positive, Gram-negative, and anaerobic organisms, including many multidrug-resistant strains.

  • The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. C6-HSL is a small diffusible signaling molecule involved in quorum sensing, controlling gene…

  • A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).

  • L-NAME (hydrochloride)

    Cayman Chemical

    A methyl ester prodrug form of the NOS inhibitor L-NNA; exhibits Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively.

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • Miconazole (nitrate)

    Cayman Chemical

    A widely used antifungal imidazole that interferes with ergosterol synthesis in fungal cell membranes; induces reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.

  • Icariin

    Cayman Chemical

    An inhibitor of human recombinant PDE5 (IC50 = 5.9 µM); used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity; induces differentiation of cardiomyocytes and increases the proliferation and differentiation of cultured human osteoblasts.

  • L-NMMA (acetate)

    Cayman Chemical

    A relatively non-selective inhibitor of all NOS isoforms with Ki values 0.18, 0.4, and 6 µM for nNOs (rat), eNOS (human), and iNOS (mouse), respectively.

  • Latanoprost (free acid)-d4

    Cayman Chemical

    An internal standard for the quantification of latanoprost (free acid) by GC- or LC-MS.

  • Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally,…

  • Sulforhodamine 101

    Cayman Chemical

    A nonfixable red fluorescent dye (excitation max: 586 nm; emission max: 605 nm) that can be used as a specific marker for astrocytes and an activity-dependent probe for monitoring regulated exocytosis.

  • CBL0137

    Cayman Chemical

    A water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM; has broad anticancer activity in mice when administered orally.

  • Ispinesib

    Cayman Chemical

    The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM)…

  • Phomopsin A

    Cayman Chemical

    A cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain; blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.

  • Guaiacol

    Cayman Chemical

    Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of COX enzymes. It can therefore serve as a reducing co-substrate for COX reactions. The one-electron oxidation…

  • Syringic Acid

    Cayman Chemical

    A naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol; inhibits aldose reductase (IC50 = 213 µg/ml), proteasome activity, and cancer cell proliferation.

  • AMC Arachidonoyl Amide

    Cayman Chemical

    AMC-AA is one of several fatty acid amides which can be used to measure FAAH activity. Exposure of AMC-AA to FAAH results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm, allowing for fast and convenient measurement of FAAH activity using a simple…

  • Lipoxin A4 methyl ester

    Cayman Chemical

    A more lipid soluble, prodrug formulation of LXA4.

  • 8-Hydroxyguanosine

    Cayman Chemical

    8-Hydroxyguanosine is produced by oxidative damage of RNA. It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxyguanosine (5-8 mM) is added to friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.

  • Imiquimod

    Cayman Chemical

    An imidazoquinoline compound that activates TLR7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC50 = 2 µM).

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