A proposed anti-inflammatory EPA metabolite that has been shown to promote inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.

A DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis.

An internal standard for the quantification of ±11(12)-EET by GC- or LC-MS.

A potential metabolite of PGD2, presumably produced from the known metabolite 13,14-dihydro-15-keto PGD2.

Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. iPF2α-VI is one of dozens of possible stereo- and…

An internal standard for the quantification of 8,12-iso-iPF2α-VI by GC- or LC-MS.

Source: Recombinant protein expressed in E. coli MW: 12.5 kDa

A 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-LO and sEH co-incubated with DHA; reduces neutrophil infiltration in a mouse model of peritonitis and enhances human macrophage phagocytosis of zymosan A.

A major urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74.

Source: Human recombinant PP2A catalytic subunit expressed in insect cells with an N-terminal octahistidine-tag followed by a streptactin-tag. The C-terminal leucine 309 was deleted. MW: 38.6 kDa PP2A is a divalent cation-independent protein serine/threonine phosphatase involved in regulating…

A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1.

A fluorescent probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

An inositol-1,4,5-trisphosphate receptor antagonist; completely blocks the increase in intracellular calcium in vascular smooth muscle cells at a concentration of 25 µM.

An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM), and limits leukocyte infiltration in a mouse model of peritonitis.

A natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

A 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A; reduces infiltration of neutrophils into the mouse peritoneum and increases phagocytosis of FITC-labeled zymosan A by macrophages.

A potential metabolite of either PGF1α or PGF2α and likely precursor to tetranor-PGFM.

A methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

An internal standard for the quantification of Lipoxin A4 by GC- and LC-MS.

Consists of PtdIns-(4)-P1 conjugated with fluorescein; can be used both in vitro and in a range of cell types following delivery with polyamine carriers.

An internal standard for the quantification of ent-8-iso-15(S)-PGF2α by GC- or LC-MS.

11-dehydro-2,3-dinor TXB2 has been identified as a TXB2 metabolite in human urine by GC/MS. The relative abundance is only about one-tenth that of 11-dehydro TXB2, making it unlikely that 11-dehydro-2,3-dinor TXB2 will be used widely as an index of thromboxane synthesis.

Consists of PtdIns-(4)-P1 (1,2-dioctanoyl) conjugated to biotin to be used as an affinity probe to detect proteins with a high-affinity binding interaction with inositol-(4)-monohosphate phospholipids.

A methyl ester version of RvD2 which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

An internal standard for the quantification of (±)5(6)-EET by GC- or LC-MS.

An internal standard for the quantification of ent-8-iso-PGF2α by GC- or LC-MS.

A potential metabolite of PGE2, presumably produced from the known metabolite 13,14-dihydro-15-keto PGE2.

PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate…

(±)8(9)-EET-d11 contains 11 deuterium atoms at the 16, 16' , 17, 17' , 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET (Item No. 50351) by GC- or LC-mass spectrometry (MS).…

A methyl ester version of 17(R)-RvD1 which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

A fluorescent probe for any protein with a high affinity binding interaction with inositol-(4,5)-triphosphate phospholipids, such as PI-3-kinase, PTEN, or PH-domain-containing proteins.

An internal standard for the quantification of RvD2 by GC- or LC-MS.