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  • Normal Phase Silica Columns

    Separation Methods Technologies

    When silica is used as the stationary phase, the functional groups involved in separation are the surface silanols. However, metal impurities in silica may provide additional sites of interaction for solutes of interest. SMT uses high purity silica packing materials that are available in variety of…

  • Bulk Diol 1

    Separation Methods Technologies

    SMT-Diol bulk packings are developed as an alternative for silica bulk packings used in separation methods. The Diol [-OH] functional group is controlled, and as such, provides more reproducible separation when compared to separation on silanols [-OH] from bare silica surface. Furthermore, the…

  • Specialty C30 Columns

    Separation Methods Technologies

    SMT-C30 columns consist of Triacontyl as the functional ligand. The columns offer selectivities that are much different from C18 reversed-phase columns when applied to separation of carotenoid and related compounds. Carotenoids consist of very diverse groups of molecules that include nonpolar…

  • Specialty CIB-Ovomucoid Columns

    Separation Methods Technologies

    SMT manufactures the first series of commercially available silica based CIB-Ovomucoid columns for high performance chiral separation of acid, base and neutral molecules. This total coverage technology ensures complete elimination of non-specific binding sites on the silica surface. The rigidity of…

  • Reversed-Phase Phenyl 2 Columns

    Separation Methods Technologies

    SMT-Phenyl column provides unique selectivity for aromatic compounds when compared to other reversed-phase packings such as C18 and C8. The pie electrons of the phenyl group can interact with the aromatic ring of an analyte to increase retention relative to less or non-aromatic analytes. Unique…

  • Specialty Chiral 2 Columns

    Separation Methods Technologies

    Chiral compounds, or enantiomers have identical molecular structures that are related as mirror images of one another much like a left hand is related to a right hand. Rapid and accurate stereochemical resolution of enantiomeric molecules has become a challenge in various aspects of pharmaceuticals…

  • Ion-Exchange WAX Columns

    Separation Methods Technologies

    SMT-WAX columns are silica-based Weak Anion eXchange packing materials developed for separation of anionic compounds. SMT-WAX consists of chemically attached hydrophilic surface derivatized to form polyethyleneimine functionality. The technique of SAM is used in the bonding process to significantly…

  • Bulk Silica

    Separation Methods Technologies

    SMT manufactures the most reliable silica based packing materials available in the market today. When silica is used as the stationary phase, the functional groups involved in separation are the surface silanols. However, metal impurities in silica may provide additional sites of interaction for…

  • O Series Reversed-Phase C8 Columns

    Separation Methods Technologies

    O Series SMT SAM-C8 phase with the highest functional ligand coverage confirmed with carbon analysis results of 12% carbon load. In these series, a very high density of the functional ligand, octyl molecule or C8, is achieved through meticulous mixture of the C8 with proprietary spacer…

  • AquSep Reversed-Phase C18 Columns

    Separation Methods Technologies

    SMT AquSep is unique reversed phase packing material designed to have both hydrophobic and truly hydrophilic spacer ligands. The mixed-phase consists of a meticulously controlled mixture of hydrophobic, C18 molecules, and proprietary hydrophilic molecules, chemically attached on the silica…

  • Reversed-Phase MEB1 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

  • Ion-Exchange DEAE Columns

    Separation Methods Technologies

    SMT-DEAE [Di-Ethyl-Amino-Ethyl] column provides a unique chemically attached hydrophilic, weak anion exchange type, functional surface desirable for the separation of many biomolecules such as proteins, nucleotides, oligonucleotides, polynucleotides, high molecular weight RNA?s and plasmid DNA?s.…

  • Reversed-Phase MEB2 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

  • OL Series Reversed-Phase C8 Columns

    Separation Methods Technologies

    OL Series SMT SAM-C8 phase with the lowest functional ligand coverage confirmed with carbon analysis results of 6% carbon load. In these series, the proportional ratio of the functional ligand, octyl or C8 molecule , mixed with the proprietary spacer molecule, is reduced. The result is a…

  • Ion-Exchange SAX Columns

    Separation Methods Technologies

    SMT-SAX columns are silica-based Strong Anion eXchange packing developed for separation of anionic compounds. SMT-SAX packings consist of chemically attached hydrophilic surface derivatized to form quaternary amine. The technique of SAM is used in the bonding process to significantly increase the…

  • Specialty C12 Columns

    Separation Methods Technologies

    SMT-C12 columns consist of Dodecyl as the functional ligand. The columns offer selectivities that are slightly different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C12 columns are specially designed as complementary alternatives for the…

  • Bulk C8

    Separation Methods Technologies

    SMT manufactures the most reliable silica based octyl (C8) column available in the market today. This advanced new column is very stable at a wide pH range and high temperatures. SMT utilizes a proprietary bonding scheme that allows the resulting bonded phases to perform separation of basic,…

  • Normal Phase Aminopropyl Columns

    Separation Methods Technologies

    SMT manufactures very stable aminopropyl [NH2] columns. SMT aminopropyl columns are often recommended for the separation of polar compounds and can be used in three separation modes: Normal Weak Anion Exchange Reversed-Phase In normal phase mode, the columns can be used to…

  • Specialty CIB-ProteinA Columns

    Separation Methods Technologies

    SMT CIB-ProteinA are silica-based packing materials de- signed for both high performance and low-pressure purification of antibodies, IgG. In production of the ProteinA affinity-type columns, SMT utilizes its proprietary technique of self-assembled monolayer (SAM) of bonding to first immobilize…

  • Bulk Aminopropyl

    Separation Methods Technologies

    SMT manufactures very stable aminopropyl [NH2] packings. SMT aminopropyl columns are often recommended for the separation of polar compounds and can be used in three separation modes: Normal Weak Anion Exchange Reversed-Phase In normal phase mode, the columns can be used to…

  • Bulk WCX

    Separation Methods Technologies

    SMT WCX Bulk Packings are silica-based Weak Cation eXchange packing materials developed for separation of cationic compounds. SMT WCX Bulk Packings consist of chemically attached hydrophilic surface derivatized to form carboxylic acid functionality. The technique of SAM is used in the bonding…

  • Ion-Exchange SCX Columns

    Separation Methods Technologies

    SMT-SCX columns are silica-based Strong Cation eXchange packing materials developed for separation of cationic compounds. SMT-SCX consists of chemically attached hydrophilic surface derivatized to form sulfonic acid functionality. The technique of SAM is used in the bonding process to significantly…

  • Bulk DEAE

    Separation Methods Technologies

    SMT-DEAE [Di-Ethyl-Amino-Ethyl] column provides a unique chemically attached hydrophilic, weak anion exchange type, functional surface desirable for the separation of many biomolecules such as proteins, nucleotides, oligonucleotides, polynucleotides, high molecular weight RNA’s and plasmid…

  • Reversed-Phase C3 Columns

    Separation Methods Technologies

    SMT SAM-C3 columns consist of Propyl as the functional ligand. The columns offer selectivities that are different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C3 columns are specially designed as complementary alternatives for the separation…

  • Bulk MetalSep

    Separation Methods Technologies

    SMT MetalSep is offered as bulk packing materials for low pressure liquid chromatography, solid phase extraction, preparatory and process scale applications. The packings consist of proprietary strong cation exchange functional ligands that are chemically attached on silica substrate using SAM…

  • Reversed-Phase Phenyl-Hexyl Columns

    Separation Methods Technologies

    SMT Phenyl-Hexyl column or PhenH column, like the other SMT Phenyl columns, provides unique selectivity for aro- matic compounds when compared to other reversed-phase packings such as C18 and C8. The ìÛ-electrons of the phe- nyl group can interact with the aromatic ring of an analyte…

  • Specialty PFP Columns

    Separation Methods Technologies

    SMT-C6F5 columns consist of Pentafluorophenyl as the functional ligand. The columns offer selectivities that are different from other reversed-phase columns when applied to separation of halogenated compounds, ketones, esters, and taxols. Taxol has been approved by the US Food and Drug…

  • Normal Phase Diol 2 Columns

    Separation Methods Technologies

    SMT-Diol columns are developed as an alternative for silica columns used in normal phase separation methods. The Diol [-OH] functional group is controlled, and as such, provides more reproducible separation when compared to separation on silanols [-OH] from bare silica surface. Furthermore, the…

  • Specialty TNT Columns

    Separation Methods Technologies

    SMT-TNT columns are specially designed C18 column for use in the reversed-phase separation of nitroaromatic and nitroamine derivatives. The isomeric nature of these explosive compounds is the reason for the difficulty in their separation. The standard test method for the analysis of seven…

  • Specialty CIB-IgG Columns

    Separation Methods Technologies

    SMT CIB-IgG are silica-based packing materials designed for for both high performance and low-pressure purification of protein A. In production of the IgG affinity-type columns, SMT utilizes its proprietary technique of self-assembled monolayer (SAM) of bonding to first immobilize unique mixed…

  • Specialty Urea Columns

    Separation Methods Technologies

    SMT Urea columns consist of proprietary hydrophilic molecule as the functional ligand. The columns offer water-soluble functionality and selectivities that are different from other reversed-phase or normal phase columns when applied to separation of polar and basic compounds. SMT-Urea columns are…

  • Reversed-Phase MEB4 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

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