Cayman Chemical

A mycotoxic cytochalasin that targets filamentous actin and demonstrates antibacterial and nematicidal effects as well as induces apoptosis in cancer cell lines.

An endogenous homolog of arachidonyl glycine that inhibits AEA hydrolysis in FAAH-containing N18TG2 cell membranes with an IC₅₀ value of 25 µM.

A synthetic chlorin with light-activated actions that accumulates in tumor cells; triggers the generation of reactive oxygen species when stimulated with light (650-652 nm) in the presence of oxygen, leading to necrosis within the tumor.

Derived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate; dose-dependently suppresses the NF-κB-dependent induction of TNF-α by LPS in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.

Antigen: Ba/F3 cell line expressing human TLR4 cell surface antigen Isotype: IgG2aK Host: mouse, clone HTA125 Cross Reactivity: (+) human and canine TLR4 Application(s): FC (cell surface and intracellular), ICC, IP, and neutralization TLR4 is mediator of innate immunity that is essential for...

A prodrug of a potent FP receptor agonist.

A potential metabolite of fluprostenol when administered to animals; a common minor impurity found in commercial preparations of the bulk drug compound.

Source: 5 µg of recombinant C-terminal His-tagged protein expressed in baculovirus expression system Mr: 50.7 kDa HDAC9 is a Class IIa HDAC that can shuttle between the nucleus and cytoplasm, suggesting possible extranuclear functions including regulating the acetylation status of non-histone...

An inhibitor of HDACs, inhibiting maize HDAC (IC₅₀ = 100 nM) as well as human HDAC1 (IC₅₀ = 46 nM); shows a 3-fold selectivity for HDAC6 over HDAC1.

Thromboxane A2 (TXA2), produced from arachidonic acid, causes irreversible platelet aggregation, vascular, and bronchial smooth muscle contraction. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2. However, most of the TXB2 measured in the plasma or urine of healthy individuals is due to ex...

A synthetic version of the endogenous antidiuretic hormone arginine vasopressin; acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.

A non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects.

A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is...

A more lipophilic analog of α-lipoic acid, a cyclic disulfide antioxidant with enhanced potency.

A monobactam antibiotic that is effective against Gram-negative bacteria but inactive against Gram-positive bacteria.

A selective JAK2 inhibitor that blocks signaling (IC50 = 58 nM at 5 mM ATP) and proliferation of JAK2-expressing cell lines (GI50 = 60 nM); displays good pharmacokinetics in vivo, inhibits STAT3 and STAT5 activation in vivo, and suppresses tumorigenesis in mouse xenografts harboring constitutive...

An antagonist/partial agonist of the androgen receptor (IC₅₀ = 26 nM in humans) that has been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia; suppresses accessory sexual glands and fertility in adult male rats (10...

8-iso PGF1β is a potential autoxidation product of DGLA. There are no published reports on its isolation from any biological source or on its biological activity.

A selective, cell-permeable inhibitor of CK2 (IC₅₀ = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases; induces cell death in Jurkat adult T cell leukemia cells (DC₅₀ = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose...

Antigen: human recombinant synovial sPLA2 Host: rabbit Cross-reactivity: (+) human (type IIA) and rat cardiocyte sPLA2; (−) human sPLA2 (type V), bee venom (type III), snake venom (Naja naja), bovine pancreas, and porcine pancreas sPLA2 Applications: WB, IP, and IHC; other applications not...

A polypeptide released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite; cleaved to PYY (3-36}), a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC₅₀ = 9.7 nM in human colon mucosa);...

A potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC₅₀ = 70 nM); has little or no effect against PDGFR, EGFR or IGF1R kinases (IC₅₀ > 100 µM).

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr292 of human MEK1 Host: rabbit Cross Reactivity: (+) human and rat MEK1; expected to react with bovine, canine, chicken, mouse, non-human primates, and Xenopus MEK1 Application(s): WB MEK1 is an integral component of...

An elongation product of γ-linolenic acid (18:3), rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4); metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins; can reduce atopic dermatitis and atherosclerosis when added to the diet of...