Cayman Chemical

A form of 12(S)-HETE with an ω-terminal alkyne for use in click chemistry reactions.

A cell-permeable, selective inhibitor of SIRT2 (IC₅₀ = 3.5 μM) that minimally affects either SIRT1 or SIRT3; rescues dopamine neurons from α-synuclein toxicity in both in vitro and in vivo Parkinson’s disease models.

Tumor necrosis factor-α (TNF-α) mediates many immune and inflammatory responses including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells. Cayman’s TNF-α (mouse) ELISA Kit...

A second-generation antipsychotic designed to antagonize both D2 and 5-HT2A receptors with little effect on cholinergic and β-adrenergic receptors; affects α2-adrenergic and histamine H1 receptors.

Host: mouse, clone 2C4 Isotype: IgM Cross Reactivity: (+) human and mouse dsDNA Application(s): ELISA, FC, and IF

A fluorescent substrate for calpain and papain (excitation max: 360 nm; emission max: 460 nm) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome.

A non-selective α-adrenergic receptor antagonist with pKi values of 8.5, 9, and 8.4 for human α1A, α1B, and α1D adrenoceptors, respectively; used to relax smooth muscles of the prostate in clinical studies designed to examine treatments that improve lower urinary tract...

A metal ion chelator used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.

A synthetic intermediate used in glycosylation reactions.

The physiological intermediate in the oxidation of choline to betaine.

An antagonist of REV-ERBα (EC₅₀ = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112; stimulates the expression of the REV-ERBα target genes G6Pase and PEPCK in liver cells; used to elucidate the role of REV-ERBα in regulating glucagon...

A derivative of the amide of linoleic acid that shows potent antiproliferative activity against an array of cancer of cell lines.

A broad-spectrum inhibitor of TACE, other ADAMs, and other MMPs; inhibits PMA-induced shedding of various cell surface proteins, such as TGF-α, βAPP, L-selectin, IL-6 receptor α subunit (IC₅₀ = 10 µM); prevents mobilization of the growth factors TGF-α and...

A natural plant phenolic that shares features of coumarins and catechols; inhibits lipoxygenases (LOs), including 5-LO and 12-LO (ID50s = 4 and 2.5 µM, respectively); used as an antioxidant to reduce reactive oxygen species and modulate oxidant-sensitive enzymes.

A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.

An inhibitor of LAT1 that blocks the uptake of L-leucine with an IC₅₀ value of 131.5 µM and can inhibit all members of the LAT family at a concentration of 10 mM; suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.

A biotinylated reagent used for the detection and quantification of apurinic/apyrimidinic (AP) sites in damaged DNA; reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, thereby covalently linking biotin to these AP sites.

Source: recombinant enzyme expressed in HEK cells MW: 45 kDa

A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.

A potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 μM); does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases; blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in...

Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED₅₀ = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC₅₀ = 0.35 µM), and...

A cell permeable spin trap commonly used in free radical research that protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects.

A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM), ALK4 (IC₅₀ = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

Major urinary metabolite of PGE1 and PGE2 that is used as a marker of PGE2 biosynthesis.