Cayman Chemical

An internal standard for the quantification of 1-AG by GC- or LC-MS.

A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers.

An ethyl ester prodrug of the JMJD3 selective histone demethylase inhibitor GSK-J1; reduces LPS-induced proinflammatory cytokine production, including that of TNFα (IC50 = 9 µM) in human primary macrophages.

5-cis Iloprost is the C-5 cis-isomer of iloprost, a second generation structural analog of PGI2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable prostacyclin analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 53.3 kDa

A natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes; prevents proliferation and induces apoptosis in human cancer cells; also acts as a proteasome inhibitor.

A fluorescent calcium indicator that displays a low affinity for calcium (Kd = 19 µM).

Antigen: Acetylated KLH Host: mouse Cross-reactivity: (+) acetylated lysine residues; (−) non-acetylated lysine residues Applications: ELISA, ICC, and WB Isotype: IgG1 This antibody is useful for monitoring levels of acetylation on various proteins (e.g., histones and p53).

A selective 15-PGDH inhibitor.

A saturated fatty acid found naturally in fish and vegetable oils or formed by the hydrogenation of arachidonic acids LDLs.

An inactive analog of the PHGDH inhibitors NCT-502 and NCT-503.

A fluorescent fatty acid analog that alters its fluorescent emission spectra and intensity on entry into binding proteins.

A selective HDAC6 inhibitor (IC₅₀ = 4 nM) used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.

Source: Recombinant N-terminal His- and SUMO-tagged protein expressed in E. coli Mr: 42.6 kDa

A naturally occurring electron donor for eight different enzymes, including those related to collagen hydroxylation, carnitine synthesis (which aids in the generation of ATP), norepinephrine synthesis, tyrosine metabolism, and amidating peptides.

An inhibitor of β-lactamases with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC₅₀s = 97, 150, and 8.5 nM); also inhibits the class D oxacillinase OXA-2 (IC₅₀ = 10 nM).

A broad-spectrum antibiotic with a prolonged serum elimination half-life in animals.

An endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption.

A selective inhibitor of PFKFB3 (IC₅₀ = 207 nM); rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.

A potential metabolite of travoprost when administered to animals.

An orally active small molecule drug with antioxidant, anti-inflammatory, and anti-fibrotic effects; reduces inflammatory cytokine production, suppresses TGF-β expression, and lowers markers of oxidative stress; has effectiveness in IPF and other conditions with a significant fibrotic...

A prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112), which binds both Hsp90α and Hsp90β with an IC₅₀ value of 30 nM; reduces tumor growth and prolongs survival in mouse models of multiple myeloma and prostate cancer when given orally.

Methylmalonic acid-d3 is intended for use as an internal standard for the quantification of methylmalonic acid (Item No. 14885) by GC- or LC-MS. Methylmalonic acid is a dicarboxylic acid and byproduct of propionate catabolism.{64351} It impairs mitochondrial respiration, increases glucose...

An intermediary metabolite of clopidogrel that is converted to an active metabolite via oxidation.