Cayman Chemical

Source: recombinant N-terminal His-tagged protein expressed in E. coli Mr: 19.3 kDa

A major urinary metabolite of the selective serotonin reuptake inhibitor paroxetine; may be used as a control in LC/MS or GC/MS paroxetine testing applications.

A member of the inositol phosphate (InsP) family of small, soluble second messengers; inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells; exhibits antiangiogenic activity as well as antitumor effects; binds to the PH domain of...

A selective antagonist of the dopamine D1-like receptor subtypes D1 and D5 (Kis = 0.2 and 0.3 nM, respectively); useful for studying the role of the dopamine system in normal brain function and neurological disorders.

A primary metabolite of ?9-THC

A selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells (pIC50 = 5.99) without effecting those mediated by GPR120 at concentrations up to 10 μM; at 1 μM, inhibits the potentiating effects of GPR agonist, GW 9508 and linoleic acid on glucose-stimulated insulin secretion.

An intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids; also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.

A certified reference material categorized as a phytocannabinoid; has been found in strains of Cannabis; intended for research and forensic applications

EDHF is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (NO) and COX-derived (prostacyclin) vasodilators. CYP450 metabolism of PUFAs, produces epoxides such as (±)14(15)-EpETrE which are prime...

An irreversible inhibitor of AChE (IC₅₀ = 4.15 µM) and BuChE (IC₅₀ = 37 nM); used in modifying the course of neurodegenerative diseases.

n-Triacontanol is a plant growth regulator found in the plant cuticle waxes and in beeswax as the palmitate ester. n-Triacontanol has been reported to have growth enhancing properties when applied to the leaves of growing plants.

LSD1 is a histone demethylase whose actions on specific lysine residues alter transcription of chromosomal DNA. It also inhibits the tumor suppressor activity of p53 by demethylating a specific lysine residue. Inhibitors of LSD1 are important tools used to elucidate mechanisms of transcription and...

A long-lasting antagonist of nAChRs and ganglion blocker.

A cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC₅₀ values of 1-11 nM; effective in vivo, suppressing the production of NO, TNF-α, IL-6, and IL-1β in mice treated with LPS when given...

Cayman's Calcium Assay provides a quick, reliable method for determining total calcium concentration in a variety of biological samples, as well as tissue homogenates and cell lysates. The assay utilizes an optimized variant of the well-established o-Cresolphthalein-calcium reaction in which a...

20-HETE is a major biologically active CYP450 metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC₅₀...

A 9β-hydroxy isomer of 5-trans PGF2α.

A potent, selective S1P1 receptor antagonist that exhibits a Ki value of 77 nM for the human receptor with no activity at 10 µM at S1P2, S1P3, or S1P5 receptors; causes capillary leakage and inhibition of S1P1 agonist-induced lymphocyte sequestration in vivo.

A selective inhibitor of cFMS kinase (IC₅₀ = 0.03 μM) that prevents CSF-1-induced monocyte growth with an IC₅₀ value of 0.14 μM; at 75-100 mg/kg, inhibits joint connective tissue and bone degradation in mouse models of arthritis.

A potent inhibitor of PDE5 (IC₅₀ = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC₅₀s = 2, 230, and 130 nM, respectively).

Application: ELISA and WB

A nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2’ position of the sugar residue; triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively).

A potent antagonist of the LTB4 receptor, BLT1, that inhibits the specific binding of radiolabeled LTB4 to isolated human neutrophils (IC50 value of 17.6 nM); inhibits the LTB4-induced chemotaxis of human neutrophils (IC50 value of 6.3 nM).

Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide (Item No. 19888) by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 µM).{34125} It is selective for SUR1/Kir6.2...