Cayman Chemical

The active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum.

An isotopically enriched form of a PUFA with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

An inhibitor of poly(ADP-ribose) polymerases (PARPs) (Ki = 1.8 μM); has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that oxidize a wide range of endogenous and exogenous aldehydes to their corresponding carboxylic acids, which affect both developmental and toxicological functions. Pharmacological inhibitors or activators of ALDH activity have been...

A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes.

An irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain; inhibits effector caspases-2, -3, -6, and -7 (IC₅₀ = 6-32 µM) without affecting the initiator caspases-8 and -10; can be used both in cells and in vivo.

A potent and selective inhibitor of Vps34 (IC₅₀ = 25 nM in vitro); induces a rapid and pronounced loss of phosphorylation of SGK3.

Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 µM.

An inhibitor of Wnt production that impairs Wnt pathway activity (IC₅₀ = 27 nM in vitro) by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins; used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation,...

Antigen: human EP4 receptor C-terminal amino acids 459-488 Host: rabbit Cross Reactivity: (+) human, mouse, ovine, and rat EP4 receptors; (−) EP1, EP2, and EP3 receptors Application(s): FC and IF Binding of PGE2 to the EP4 receptor causes an increase in intracellular cAMP and subsequent...

A lipophilic analog of PGA1 which may be more suitable for certain formulations or applications.

Antigen: full-length recombinant human HMGB1 Host: mouse, clone IMG19N12A1 Isotype: IgG1k Cross Reactivity: (+) human and mouse HMGB1 Application: WB HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding...

(±)15-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)15-HETE is similar to that of its constituent enantiomers (Item Nos. 34720 and 34710).

An inhibitor of EGF receptor kinase with an IC50 value of 3 µM in HT-22 cells.

An ATP-competitive inhibitor of Akt2 (IC₅₀ = 6 nM); blocks the phosphorylation of Akt targets, inhibits proliferation of multiple tumor cell lines in vitro, and prevents the growth of human tumor xenografts in mice.

Selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM); significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.

A synthetic derivative of staurosporine that inhibits a variety of kinases, including Akt, protein kinase C (IC₅₀ = 30 nM), PDK1 (IC₅₀ = 6 nM) and cyclin-dependent kinases (IC₅₀s = 300-600 nM for Cdk1 and Cdk2); arrests tumor cells in the G1/S phase of the cell cycle...

A γ-linolenic acid ester of 7-hydroxycoumarin that behaves as a substrate for cPLA2.

Source: recombinant human C-terminal His-tagged protein expressed in Sf21 cells MW: 64.3 kDa

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 40.8 kDa CREBBP bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53.

A rare PUFA produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGES.

3-Thiopheneacrylic acid methyl ester is a synthetic intermediate useful for pharmaceutical synthesis.

An anthelmintic antibiotic that at 0.001 µg/ml is fully effective at inhibiting growth in an H. contortus larval development assay.

A synthetic intermediate useful for pharmaceutical synthesis.