Cayman Chemical

A synthetic analog of PGA2 with structural features similar to 15-deoxy-Δ12,14-PGJ2, a ligand for PPARγ.

An atypical antidepressant with diverse actions, most notably on the glutamatergic system; attenuates glutamate release and modulates the function of AMPAR; acts as an agonist of the µ-opioid receptor (EC₅₀s = 194 and 641 nM for human and mouse receptors, respectively).

Antigen: TIM4 from mouse peritoneal cells Host: Armenian hamster Cross Reactivity: (+) human, mouse, and rat TIM4 Application(s): FC and ICC

A potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM); prevents CXCR4/SDF-1-mediated modulation of cAMP (EC50 = 1.2 nM) in cells; blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM).

Antigen: synthetic peptide from human HSL amino acids 731-741 Host: rabbit Cross Reactivity: (+) human, mouse, and rat HSL Application(s): WB HSL catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters

A reversible inhibitor of both agonist and antagonist binding to diverse GPCRs; blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors with IC₅₀ values of 0.1 to 1.8 µM.

The major secretory product of adrenal glands and the predominant circulating precursor for active steroid hormones in humans; used as a biomarker in some adrenocortical disorders.

An endocannabinoid containing dihomo-γ-linoleate in place of the arachidonate moiety of AEA; binds to recombinant human CB1 and CB2 receptors with Ki values of 857 and 598 nM, respectively.

A precursor in the biosynthesis of porphyrins; used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases; also used in fluorescence-based identification of tumor tissue for accurate resection of diseased tissue.

A selective inhibitor of the interaction of WDR5 with peptide regions of MLL and Histone 3; binds to WDR5 with a Kd = 24-52 nM and disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells at IC₅₀ values below 1 µM.

Source: Active recombinant N-terminal His-tagged enzyme amino acids 1-355 expressed in E. coli Mr: 43.7 kDa SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to...

5-cis-15(R)-Iloprost is the C-5 cis-isomer and 15(R)-epimer of iloprost, a second generation structural analog of PGI2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable prostacyclin analogs, typified by carbaprostacyclin. There are no published studies of...

Methylation of key biological molecules and proteins plays important roles in numerous biological systems, including signal transduction, biosynthesis, protein repair, gene silencing, and chromatin regulation. The SAM dependent MTs use SAM as the enzymatic cofactor. SAM, also known as AdoMet, acts...

A guanine analog with antineoplastic activity; irreversibly inactivates AGT, with 40% reduction in alkyltransferase activity achieved at 0.06 µM with recombinant human AGT; effective in vivo as well as in vitro.

11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.

A CYP2C9 metabolite of the potassium channel blocker??, tolbutamide.

An inhibitor of the expression of CCL2, CCL7, and CCL8, as well as IL-12; prevents LPS or C. albicans-induced production of CCL2 in human monocytes (IC50s = 172 and 403 µM, respectively) and downregulates the NF-κB pathway, preventing p65 and p65/p50-mediated CCL2 promoter activation.

Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.

A fluorogenic substrate that can be cleaved specifically by caspase-3.

A phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.

An internal standard for the quantification of CEP-Lysine by GC- or LC-MS.

17-phenyl trinor PGD2 is a novel, chemically stable analog of PGD2 wherein the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms. This modification has not been reported in a D-type prostaglandin. However, in the PGE and PGF...

Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kDa glutathione-independent lipocalin-type PGD2 synthase. This PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized in mast cells and leukocytes by a...

A dye which stains proteins in gels with ease and sensitivity; used in the Bradford to quantify the amount of protein in a solution; selectively inhibits P2X7 (IC₅₀s = 10.1 nM and 265 nM for rat and human P2X7, respectively) and reduces neurological injury secondary to traumatic brain...