Source: Active recombinant N-terminal His-tagged enzyme amino acids 1-355 expressed in E. coli
Mr: 43.7 kDa
SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature aging disorder associated with a shortened life span.