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A group A trichothecene mycotoxin derived by the metabolism of T-2 toxin.
A sensitive fluorescent substrate for sEH that can be used to monitor the activity of both human and mouse enzymes.
An ATP-competitive, pan-Akt kinase inhibitor (IC50s = 2, 13, and 9 nM for Akt1, 2, and 3, respectively) that inhibits proliferation and induces apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice.
A synthetic intermediate useful for pharmaceutical synthesis.
RS 504393 is a selective antagonist of the MCP-1 receptor CCR2 (IC50s = 89 nM and >100 μM for CCR2 and CCR1, respectively). It has been shown to inhibit MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.
A form of the 14-carbon myristic acid with an ω-terminal alkyne group; can be used in linking reactions utilizing click chemistry.
PUFAs are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet. Methyl GLA is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an...
An internal standard for the quantification of DHA ethyl ester by GC- or LC-MS.
A water-soluble parthenolide analog; inhibits the proliferation and metastasis of various tumor cells by targeting NF-κB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF.
A positive allosteric modulator of the α7 neuronal nAChR, increasing agonist-evoked calcium flux (EC50 = 216 nM); increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.
A derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.
An endogenous CB found in brain, liver, and other mammalian tissues found to have anti-anaphylactic and anti-inflammatory activity in vitro; an endocannabinoid that significantly elevates cAMP in cells expressing CB2 receptors; demonstrates low affinity for the CB2 receptor, at about 10 µM,...
An NO donor that can release two equivalents of NO in solution; half-life in PBS (pH 7.4) is 93 minutes at 22°C.
5-trans PGF2α tromethamine salt is a derivative of 5-trans PGF2α with increased water solubility. Its solubility in PBS is 25 mg/ml compared to 10 mg/ml for 5-trans PGF2α.
An orally-active ACE inhibitor (IC50 values range from 2 to 800 nM).
A fluorogenic, sensitive substrate for human sEH which displays good aqueous stability and solubility making it ideal for high throughput screening programs.
A member of the plant hormone family known as “cytokinins”, which regulate cell division, development, and nutrient processing; affinity of trans-zeatin for Arabidopsis histidine kinase 3 is 1.3 nM.
An analog of N-cyclohexanecarbonylpentadecylamine, a selective inhibitor of acidic PEAase (IC50 = 4.5 µM), that contains one less carbon in the alkyl chain; its biological activity has not been documented.
An inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM).
An internal standard for the quantification of AEA by GC- or LC-MS.
D-erythro-Sphingosine is formed primarily from the breakdown of ceramide. Sphingosine inhibits PKC and phosphatic acid phosphohydrolase, whereas it activates PLD and DAG kinase. Phosphorylation of sphingosine by SPHK 1 and SPHK 2 produces sphingosine-1-phosphate, a potent bioactive lipid that...
A stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives; exhibits anti-oxidant and antimutagenic effects.
A competitive inhibitor of HIF prolyl 4-hydroxylase (IC50 = 2.4-3.6 µM).