Cayman Chemical

A potent ATP-competitive inhibitor of ATM kinase (IC₅₀ = 13 nM; Ki = 2.2 nM); sensitizes cells to both ionizing radiation and chemotherapeutic agents; induces senescent breast, lung, and colon carcinoma cells to undergo cell death; inhibits HIV-1 replication in C8166 human T-lymophocyte...

An orally available azole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml); inhibits CYP isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.

An internal standard for the quantification of palmitic acid by GC- or LC-MS.

A plant hormone with diverse roles in disease resistance, plant development, and response to stresses; regulates gene expression and may contribute to epigenetic changes at the chromatin level.

The trans isomer of the 16:1 fatty acid palmitoleic acid.

An ester of the free acid that is less water soluble, but more amenable for the formulation of stearidonate-containing diets and dietary supplements.

An affinity probe designed to allow oleic acid to be detected in complexes with protein binding partners such as fatty acid binding proteins.

An analog of goniothalesdiol, a tetrahydrofuran compound known to have significant cytotoxic effects against P388 murine leukemia cells and pesticidal activities.

Peptide Sequence: human EP2 receptor amino acids 335-358 (SLRTQDATQTSCSTQSDASKQADL) To be used in conjunction with Cayman’s EP2 receptor polyclonal antibody (Catalog No. 101750) to block protein-antibody complex formation during immunochemical anaylsis for the EP2 receptor.

An internal standard for the quantification of tetranor-PGDM lactone by GC- or LC-MS.

A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

11(S)-HEPE is a monohydroxy fatty acid derived from EPA, theoretically by the action of COX. Although its arachidonate derived congener 11(S)-HETE has been isolated from cultured neutrophils, it is not known if similar incubations with EPA can produce 11(S)-HEPE.

A highly mutagenic metabolite of the carcinogenic mycotoxin aflatoxin B1.

A stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2.

Cayman’s CFSE Cell Division Assay Kit provides an easy-to-use format for labeling and tracing cells through successive cell divisions. Carboxyfluorescein diacetate, succinimidyl ester (CFDA-SE) diffuses into cells, where the acetate groups are cleaved to yield a highly fluorescent derivative...

An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC₅₀ = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary...

An alkaloid natural product that reduces total cholesterol, LDL cholesterol, and triglycerides in humans and hamsters; enhances LDL-receptor protein and mRNA levels in hepatocytes.

A tumor-promoting teleocidin compound that activates PKC (Ki = 3.4 nM and 1 μM for PKCη and PKCγ, respectively); induces differentiation of human embryonic stem cells into pancreatic progenitors.

Cayman’s HDAC Cell-Based Assay provides an easy tool for studying HDAC activity modulators in whole cells. By using a cell-permeable HDAC substrate, the activity of various protein lysine-specific deacetylases, including HDAC1-containing complexes, can be measured in intact cells in a simple...

A potent, cell-permeable inhibitor of PARP-1 (Ki = 5.5 μM); arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors.

An α-sulphonated version of arachidonic acid that may possess improved lipophilicity.

Antigen: histone 3 peptide with citrullinations at R2, R8, and R17 Host: rabbit Cross Reactivity: (+) human Application(s): ELISA and WB

Source: Recombinant N-terminal His-tagged protein expressed in E. coli

The orally bioavailable, valyl ester prodrug of ganciclovir, an antiviral agent that inhibits viral DNA synthesis (IC₅₀ = 0.95 μM) by targeting the CMV polymerase; used for the treatment of HIV associated retinitis and for the prevention of post transplant CMV infections.