Cayman Chemical

Misoprostol is a widely sold analog of PGE1 which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup. Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename...

An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor (Ki = 5.7 nM in rat brain); in vivo activity is enhanced much less than the binding affinity, because the analog is...

A selective inhibitor of 15-hydroxy PGDH (IC₅₀ = ~10 µM).

A metabolic precursor of dopamine that crosses the blood brain barrier; used to treat Parkinson’s disease and stroke damage.

An analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications

MAGL is the main enzyme responsible for the inactivation of 2-AG. Cayman’s Monoacylglycerol Lipase Inhibitor Screening Assay provides a convenient method for screening human MAGL inhibitors. MAGL hydrolyzes 4-nitrophenylacetate resulting in a yellow product, 4-nitrophenol, with an absorbance...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the mouse peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or PPARδ....

A broad spectrum rifamycin antibiotic that has applications against tuberculosis, H. pylori, M. avium complex, Chlamydia, and other bacteria.

Potently activates PKCα, PKCε, and PKCδ at nM concentrations; competitively binds to the Ras activator RasGRP (Ki = 4.49 µM) in Jurkat-T cells.

A competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 (Kis = 25, 125, and 10 nM, respectively), resulting in muscle relaxation.

A major metabolite of florfenicol, an antibiotic commonly used in veterinary medicine.

Consists of docosahexaenoic acid, an ω-3 PUFA, with glycine attached at its carboxy terminus.

A selective, irreversible JNK inhibitor (IC₅₀s = 4.67, 18.7, and 0.98 nM for JNK1, 2, and 3, respectively); prevents phosphorylation of c-Jun in A375 and HeLa cells (EC₅₀s = 338 and 486 nM, respectively).

Antigen: rat soluble guanylate cyclase β1 subunit (soluble) amino acids 188-207 Host: rabbit Cross Reactivity: (+) human, bovine, and rat soluble guanylate cyclase β1 subunit; (−) α1 subunit Application(s): IHC and WB Soluble guanylate cyclase is a heterodimeric enzyme,...

A PPAR agonist that displays potent binding at PPARα, γ, and δ (IC50s = 113, 50, 223 nM, respectively) and potently transactivates PPARα, γ, and δ (EC50s = 8, 70, 500 nM, respectively); demonstrates stronger binding and functional activity for PPARγ than...

A biguanide derivative used to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus; 50-400 mg/kg body weight inhibits complex 1 of the mitochondrial respiratory-chain and induces AMP-activated protein kinase-dependent signaling in B6-Lepob/ob mice.

Cayman's Multi-Drug Resistance Assay Kit provides a convenient tool for studying the modulation of cellular multi-drug resistance (MDR) machinery. The kit employs calcein AM, a cell-permeable nonfluorescent dye, which is cleaved intracellularly to yield the impermeant fluorescent molecule,...

A hydroxamate-based, long-chain fatty acid that reversibly inhibits MMP-2 (Ki = 1.6 µM); attenuates cancer cell migration and has been shown to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.

Immunogen: synthetic peptide from the N-terminal region of human protein Host: rabbit Cross Reactivity: (+) human, mouse, rat, porcine, and bovine β-catenin Application(s): IHC and WB β-Catenin is a multifunctional protein known to be part of the Wnt pathway, playing essential roles in...

A cell-permeant precursor of the ratiometric fluorescent calcium indicator indo-1, which is amenable to a single excitation source, typically 349-364 nm light from an argon-ion laser; emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium.

A coniferyl ester that acts as a partial agonist of TRPV1 (EC₅₀ = 3.2 µM), eliciting only 20% of the maximum response induced by capsaicin.

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser218,222 of human MEK1/2 Host: rabbit Cross Reactivity: (+) NIH 3T3 cells Application(s): WB MEK1 is an integral component of the MAPK cascade that regulates cell growth and differentiation.

The active metabolite of ramipril, an ACE inhibitor (pKi = 9.08 in human heart) that suppresses the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction; interferes with the targeting of B2 kinin receptors to endothelial cell membranes;...

An internal standard for the quantification of verapamil (hydrochloride) by GC- or LC-MS.