Cayman Chemical

An inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate); reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.

A selective inhibitor of NUAK1 (IC₅₀ = 100 nM); partially inhibits the phosphorylation of the NUAK1 substrate MYPT1 at Ser445; inhibits proliferation and migration of mouse embryonic fibroblasts and U2OS cells at 10 µM in cell-based assays.

Diheptanoyl Thio-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH. Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB...

An analog of the PKC-activating second messenger DAG.

A modulator of plant signaling.

A DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs); preferentially targets cancer cells demonstrating IC20 values of 20, 10, 20, and 5 μM for reducing proliferation of TK6, Jurkat, KG-1, and HCT116 cells, respectively.

A CYP2C9 metabolite of the NSAID diclofenac that demonstrates anti-inflammatory and analgesic properties by inhibiting COX and suppressing PGE2 synthesis.

Antigen: human PHLPP1 amino acids 1192-1205 of the α isoform, or amino acids 1704-1717 of the β isoform Host: rabbit Cross Reactivity: (+) human, mouse, rat PHLPP1α and PHLPP1β, (−) PHLPP2 Application(s): ICC, IHC (paraffin-embedded tissue), and WB PHLPP1 and PHLPP2...

A polymer film used to manufacture high-performance membranes for dialysis, reverse osmosis, ion sensing, and separation; used in the production of photographic film and polarized film for liquid crystal displays.

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; Item No. 14010) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A...

A potent, bioavailable pan-Trk inhibitor that blocks the proliferation of cells expressing TEL-TrkA, TEL-TrkB, and TEL-TrkC (IC50s = 7, 9, and 11 nM, respectively); inhibits the growth of Ba/F3 and RIE cells expressing both TrkA and NGF with IC₅₀ values of 42 and 17 nM, respectively.

Antigen: mouse IgA Host: rabbit Cross Reactivity: (+) mouse IgA; (−) murine IgG Applications: FC and IF

A structural analog of PMA that does not activate PKC; used as a negative control for PMA signaling through PKC.

A mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains that causes food poisoning in livestock and humans.

A non-steroidal SARM that has tissue-selective androgenic and anabolic effects in animals; improves muscle strength and prevents bone loss in orchidectomized rats.

A third-generation SERM that selectively binds to human ERα (IC₅₀ = 1.5 nM) and inhibits bone loss in ovariectomized rats; used in the treatment of postmenopausal osteoporosis and ER-positive breast cancer; also acts as an inverse agonist at the CB2 cannabinoid receptor.

A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver; can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety.

An LPA analog containing palmitic acid at the sn-1 position.

A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity; stimulates the production of cyclic AMP in CHO-K1 cells with an EC₅₀ value of 5.3 µM.

Inhibits microtubule polymerization (IC₅₀ =3.2 μM) by binding to tubulin, which disrupts spindle formation during mitosis; blocks the growth of MCF-7 human breast carcinoma cells (IC₅₀ = 13 nM); inhibits neutrophil motility and activity (5 μmol/kg in a mouse model of...

A streptogramin antibiotic that is usually combined with another streptogramin antibiotic, quinupristin, to synergistically kill Gram-positive bacteria.

A derivatized fluorescein compound that is used to detect the production H₂O₂ by cells; converted to fluorescein by intracellular H₂O₂, resulting in an increase in intracellular fluorescence (excitation/emission maxima: 480/512 nm).

An irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic, cytostatic, and antiparasitic effects.

Cayman’s MPO Peroxidation Fluorometric Assay provides a convenient fluorescence-based method for detecting MPO peroxidase activity in both crude cell lysates and purified enzyme preparations. The assay utilizes the peroxidase component of MPO. The reaction between hydrogen peroxide and...