Cayman Chemical

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 µM, respectively. It does not inhibit, and may actually enhance, COX activity....

An inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC₅₀ = 5.6 µM); blocks SREBP-mediated gene expression; inhibits high glucose-induced upregulation of TGF-β in primary rat mesangial cells; reduces hepatic fat...

AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular PG compounds such as latanoprost and travoprost. The pharmacology of AL 8810 methyl ester has not been published.

A selective S1P4 agonist (EC₅₀ = 46.3 nM).

Source: Active human recombinant N-terminal His-tagged protein purified from Sf21 cells Mr: 50.8 kDa PTEN functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as Akt and PIP3. Mutation of PTEN results in many human cancers including...

A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C....

CAS Number: 1219803-57-2 Synonyms: Isoflavone-d₄ Molecular Formula: C₁₅H₆D₄O₄ Formula Weight: 258.3

A cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation; also potently blocks cell growth directed by overexpression of v-Myc; effective in vivo.

Immunogen: synthetic Peptide from an internal region of human protein NAPE-PLD Host: rabbit Species Reactivity: (+) human, mouse, and rat NAPE-PLD Application(s): WB NAPE-PLD catalyzes the hydrolysis of NAPE to form NAEs, which are involved in diverse biological processes such as inflammatory...

A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides; displays high affinity for L-FABP (K_i = 24 nM); exhibits EC₅₀ values of 18 and 30 µM for murine and human PPARα, respectively, in a transactivation...

Antigen: recombinant human renin protein Host: goat Cross Reactivity: (+) human Applications: ELISA, IP, and WB

Antigen: synthetic peptide corresponding to amino acids 2-17 of human HDAC3 Host: rabbit Cross Reactivity: (+) human HDAC3 Application(s): WB, IP, and ChIP HDAC3 is a class I HDAC that plays an important role in cell development, differentiation, programmed cell death, angiogenesis, and...

An Axl kinase inhibitor.

A potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α (IC50 = 78 nM, Ki = 31 nM); similar potency for GSK3β.

A potent, dual PI3K/mTOR inhibitor (IC₅₀ values are 0.4 and 5.4 nM for PI3Kα and PI3Kγ, respectively, and 1.6 nM for mTOR); active both in vitro and in vivo, inhibiting the growth of cancer cells in culture or in xenografts in mice when delivered intravenously.

(R)-SLV 319 is the inactive enantiomer of SLV 319 with 100-fold less affinity for the CB1 receptor than (S)-SLV 319.

A peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases, including MMP-1 (Ki = 300 nM), MMP-2 (IC₅₀ ~ 90 nM), MMP-3 (Ki = 1,700 nM), MMP-7 (IC₅₀ ~ 3,500 nM), MMP-8 (Ki = 130 nM), MMP-9 (Ki = 330 nM), MMP-10 (IC₅₀ ~ 500 nM), MMP-12...

A FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid.

A non-lipid inhibitor of cellular ceramidase activity (IC50 = 28 μM in a cell-based assay); induces the accumulation of endogenous ceramide species and decreases intracellular levels of sphingosine and S1P; inhibits cell proliferation of ovarian cancer cells in vitro (IC50 = 0.71 μM) and...

A potential metabolite of PGA1, produced by 15-hydroxy PGDH; causes vasoconstriction of rabbit lung when given at a concentration of 6 µM.

A hydroxyethyl ether rapamycin derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM; orally available with superior pharmacokinetics and pharmacodynamics over rapamycin.

Antigen: a mixture of synthetic peptides corresponding two amino acids 268-282 and 337-352 of human MBD4 Host: rabbit Cross Reactivity: (+) human MBD4 Application(s): ICC, IHC, and WB MeCP2 may function as a mediator of the biological consequences of the methylation signal. It is also reported that...

PGK1 is the 9,11-diketone formed by the oxidation of PGE1 or PGD1. Whether this compound exists biologically is uncertain; it is known to be resistant to metabolism by 15-hydroxy PGDH in vitro. In an intact porcine model of balloon angioplasty restenosis, PGK1 was equivalent in activity and potency...

A highly selective ERα receptor antagonist (Ki = 5.6 nM; IC₅₀ = 80 nM).