Cayman Chemical

Source: Recombinant N-terminal His-tagged enzyme expressed in E. coli Mr: 49.3 kDa SIRT7 activates transcription by RNA polymerase I and deacetylates p53. It prevents progressive deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death...

A benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly; blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml); interferes with chromosome segregation in C. crescentus.

A serine proteases inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM); 300 mg/kg decreases the total number of eosinophils...

A potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC₅₀ value of 4 nM.

A second generation analog of amiloride that inhibits TRPP3-mediated Ca2+-activated (IC₅₀ = 0.14 μM) and ENaC (IC₅₀ = 10 nM); inhibits active sodium transport of human and ovine bronchial epithelial cells (IC₅₀s = 75 and 116 nM, respectively).

Antigen: hamster brain SAF Host: mouse, clone SAF 53 Isotype: IgG Application(s): EIA and FC

A toxin that activates GPVI on platelets and initiates blood clotting.

An extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity.

Immunogen:Synthetic peptide from an internal region of mouse TP receptor Host: Rabbit Species Reactivity: (+) Human, bovine, African green monkey, mouse, and rat TP receptor Application(s): WB The TP receptor is a GPCR that mediates the action of TXA2.

Potently inhibits STAT3 by preventing its dimerization and DNA binding at concentrations of 20-30 μM; blocks the growth and survival of cancer cells that express constitutively active Stat3 (e.g., DU145 cells, IC₅₀ = 12.2 μM); prevents the proliferation of human keratinocytes and...

A potential metabolite of latanoprost when administered to animals; common minor impurity found in commercial preparations of the bulk drug compound.

A non-selective blocker of voltage-dependent K+-channels (Kv channels) that has greatest potency at Kv1 and Kv3 family members (IC₅₀s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively); also blocks Kv2 and Kv4 subunits at millimolar...

A tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.

An active, deacetylated metabolite of T-2 toxin; inhibits protein synthesis and cell proliferation in plants; causes acute and chronic toxic effects in animals that ingest contaminated plant materials.

A potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors.

A selective S1P3 receptor antagonist (Ki = 110 nM); suppresses FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts; also inhibit S1P-induced breast cancer stem cell expansion in vitro.

Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through β-oxidation from C-1. This metabolite is 8(R)-hydroxy hexadecatrienoic acid (8(R)-HHxTrE) or 2,3,4,5-tetranor 12(R)-HETE.

A major metabolite of clozapine; used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

An immediate precursor of cholesterol; elevated in the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome, where it is subject to free radical oxidation, giving rise to several oxysterols which contribute to pathogenesis; converted by ultraviolet light to produce vitamin D3 in skin.

Peptide Sequence: murine amino acids 596-610 To be used in conjunction with Cayman’s NPC1L1 Polyclonal Antibody (Catalog No. 100065385) to block protein-antibody complex formation during immunochemical analysis of NPC1L1

An enantiomer of ibuprofen that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form; also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC₅₀s = 62 and 122 µM, respectively).

Antigen: His-tagged full-length human IKKγ Host: mouse, clone 72C627 Isotype: IgG1 Cross Reactivity: (+) human and mouse IKKγ Application(s): WB IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and...

S-methyl-L-Thiocitrulline is a potent NOS inhibitor with selectivity toward the neuronal isoform compared to eNOS and iNOS. For human enzymes, it exhibits Ki values of 1.2, 11, and 40 nM for nNOS, eNOS, and iNOS, respectively.

A tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC₅₀s = 1 nM in vitro).