Cayman Chemical

An inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Zileuton (Zyflo™) is a reversible 5-LO inhibitor that was approved in 1997 for the prevention and treatment of asthma in the USA, but was withdrawn by Abbott Laboratories in 2003. Zileuton inhibits 5-LO from rat basophilic leukemia-1 (RBL-1) cells with an IC50 value of 0.5 µM. It is a...

Antigen: synthetic peptide containing phosphorylated serine residues corresponding to human IκBα amino acids 32 and 36 Host: mouse, clone 39A1413 Isotype: IgG1κ Cross Reactivity: (+) bovine, canine, human, mouse, porcine, and rat IκBα Application(s): WB and IP External...

Antigen: a portion of amino acids 150-200 of human NF-κB (p50) Host: mouse, clone 2J10D7 Isotype: IgG1κ Cross-Reactivity: (+) human NF-κB (p50) Application(s): IHC and WB NF-κB1 (p50) is a 50 kDa functional sub-unit of NF-κB that forms homodimers or heterodimerizes with...

A natural flavanol with potent antioxidant activity.

A DHA-derived resolvin that stimulates the phagocytosis of E. coli by human macrophages.

Calcitriol is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly...

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For...

A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome...

A PPARβ/δ antagonist.

A broad-spectrum dithiolopyrrolone antibiotic; inhibits tumor angiogenesis, blocking activity of integrin αvβ3, (IC₅₀ = 1.1 µM).

Small molecule inhibitors of sEH may hold promise as therapeutics for the treatment of hypertension and vascular inflammation. Cayman’s fluorescence-based sEH Inhibitor Screening Assay provides a convenient method for screening epoxide hydrolase inhibitors. The assay utilizes...

Each vial contains nNOS (rat) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active.

A naturally occurring phospholipid produced by cells upon inflammatory stimulation; less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration.

An activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP; activates the human, rat, and mouse receptors with EC₅₀ values of 0.7, 3.6, and 285 μM, respectively.

Antigen: recombinant full-length human caspase-3 Host: mouse, clone 31A1067 Isotype: IgG1κ Cross Reactivity: (+) human, mouse, and rat caspase-3 Application(s): IHC (frozen and paraffin-embedded sections) and WB Caspase-3 cleaves the death substrate PARP to a specific 85 kDa form observed...

Antigen: human COX-2 amino acids 578-596 Host: goat Cross-Reactivity: (+) human, ovine, mouse, rat COX-2; (−) COX-1 (all species) Application(s): WB, ICC, and IHC (formalin-fixed paraffin-embedded sections) Expression of COX-2, the inducible form of COX, is regulated by growth factor tumors,...

Antigen: hamster brain SAF Host: mouse, clone SAF 84 Isotype: IgG Application(s): IHC and WB

An antifungal compound clinically used to treat nail and skin infections; inhibits ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans); induces cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells.

An internal standard for the quantification of TDGA by GC- or LC-MS.

An EpEDE acid formed from DGLA, either by a strong oxidizing agent or by cytochrome P450 epoxygenases; biological properties are poorly understood.

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53; binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and activation.

A broad-spectrum pleuromutilin antibiotic that binds to peptidyl transferase in the 50S ribosomal subunit.

A selective, potent inhibitor of the bromodomains of BRPF proteins that binds to BRPF1B, BRPF2, and BRPF3 with Kd values of 31, 108, and 408 nM, respectively, as determined by isothermal titration calorimetry.