Cayman Chemical

A unique tetrasaccharide whose biological role is not known.

A form of 4-HNE with a terminal alkyne; for use in linking reactions (click chemistry) for detection of 4-HNE-modified DNA and proteins.

Derivative of PGF1α containing an acetylenic fluorobenzene substituent in the lower side chain; binds to the recombinant human FP receptor with an IC50 value of about 0.5 µM.

A synthetic intermediate or building block for drug discovery or pharmaceutical synthesis.

A thiazide diuretic that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

A selective substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase.

Antigen: synthetic peptide from human histone H2B amino acids 111-125 Host: rabbit Cross Reactivity: (+) chicken, canine, Drosophila, human, most mammals, mouse, rat, and zebrafish histone H2B Application(s): WB Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer,...

A natural phenolic antioxidant that has analgesic, anti-inflammatory, and hepatoprotective actions in mice and rats.

A trichothecene mycotoxin produced by Fusarium; induces apoptotic cell death in human Jurkat T cells.

The Cayman Chemical hypericin is suitable for use in research facilities and chemical laboratories to conduct wide range of experiments. It is available in sturdy bottle that endures heavy and rigorous usage.

A more lipid soluble form of (+)-cloprostenol, amenable for certain formulations.

An ideal control for the inhibitor of Wnt response compound, IWR-1-endo.

A selective inhibitor of PKC-induced NF-κB pathway activation (IC₅₀ = 0.07 μM); inhibits IL-8 production in HEK293 cells (IC₅₀ ≤ 0.1 μM), attenuates production of IL-2 by Jurkat T cells (IC₅₀ ≤ 5 μM), and prevents proliferation of mouse...

An aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 (pA2 = 6.1) and the inverse agonism of SR 144528 (pEC50 = 5.3).

Ins(1,2,3,5)P4 is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,3,5)P4 exhibits relatively weak agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells, where it induces Ca2+ mobilization...

An internal standard for the quantification of ?9-THC by GC- or LC-MS; provided as a DEA exempt preparation; intended for research and forensic applications,

An internal standard for the quantification of LTC4 methyl ester by GC- or LC-MS.

Source: Active recombinant C-terminal His-tagged protein expressed in E. coli Mr: ~37 kDa Protein concentration: 0.8 mg/ml Human PGFS catalyzes the isomerization of PGH2 to PGF2a (PGH2 9,11-endoperoxide reductase activity), as well as the formation of 11b-PGF2a from PGD2 (PGD2 11-ketoreductase...

AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the inverse, (S), or “natural” configuration at C-15 relative to AL 8810, which is 15-(R). The pharmacology of (S)-AL...

CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-.DELTA.12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and...

Source: 50 µg of full length recombinant C-terminal His- and FLAG-tagged protein expressed in baculovirus expression system Mr: 56 kDa HDAC1 is a Class I HDAC that catalyzes the deacetylation of core histones and other non-histone proteins to control complex biological events, including cell...

A cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Item No. 12086) that contains an alkyne moiety for use in click chemistry reactions; used to study changes in nuclear architecture associated with cancer and certain laminopathies.

An atypical antipsychotic that most potently binds α-adrenergic, dopamine, and serotonin receptors (Kds = 180, 150, 180, 102, and 14 nM for α1, α2, D2, 5-HT2A, and 5-HT2C, respectively).

9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals. It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles.