Cayman Chemical

A thiazide-like diuretic that targets the Na+-Cl- cotransporter responsible for salt reabsorption in the distal convoluted tubule of the kidney (IC₅₀ = 0.3 µM in rat); inhibits human carbonic anhydrase isoforms VII, XII, and XIII (Kis = 2.1, 5.4, and 15 nM, respectively).

A synthetic intermediate useful for pharmaceutical synthesis.

Inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397; decreases cell viability of T47D breast cancer and C8161 melanoma cell lines at 100 µM.

Antigen: amino acids 234-249 of human SMAD2 Host: rabbit Cross Reactivity: (+) Bovine, canine, chicken, chimpanzee, human, mouse, and rat SMAD2 Application(s): IHC and WB SMAD2 is an intracellular protein that associates with SMAD4 for translocation to the nucleus. It acts as an intracellular...

A glycosphingolipid that contains one sialic residue linked to the inner galatose unit; influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis; acts as a functional coreceptor for TLR2, enabling the recruitment of TLR2 to lipid rafts when bound by a...

Cholesteryl linoleate hydroperoxides are derived from the autoxidation of cholesteryl linoleate and contain a mixture of racemic 9- and 13-HpODE cholesteryl esters. Oxidative modification of LDL is suggested to play an important role in atherosclerosis. (±)9- and (±)13-HODE cholesteryl...

Cayman’s Phagocytosis Assay Kit (IgG PE) employs latex beads coated with fluorescently-labeled rabbit IgG as a probe for the measurement of the phagocytic process in vitro. The engulfed fluorescent beads can be detected using a fluorescence microscope, allowing kinetic studies of phagocytosis...

Antigen: peptide from the N-terminal region of human GPR41 Host: rabbit Cross Reactivity: (+) human GPR41 Application(s): FC, IF, and WB

An odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications; commonly used to rapidly reduce protein and peptide disulfide bonds.

A reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively); stimulates glycogen synthase in cells (EC₅₀ = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in...

An antibacterial lipopeptide that targets Gram-positive bacteria and may be useful against drug resistant strains; also inhibits peptidoglycan synthesis.

An inhibitor of Dkk1 that activates the Wnt signaling pathway, stimulating β-catenin/TCF-dependent transcription with an EC₅₀ value of 0.63 µM; has good pharmacokinetic properties and increases trabecular bone formation in ovariectomized rats following oral administration.

Cayman’s XTT Cell Proliferation Assay provides an easy to use tool for studying induction and inhibition of cell proliferation in any in vitro model. The assay is based on the extracellular reduction of XTT by NADH produced in the mitochondria via trans-plasma membrane electron transport and...

An inhibitor of PDGFRβ, VEGFR2, and FGFR1 (IC₅₀ = 0.06, 2.4, and 3.0 μM, respectively) but not EGFR (IC₅₀ >100 μM); suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors; also...

A cytidine analog with an unnatural β-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC₅₀ = 10-20 nM) and hepatitis B (EC₅₀ = 10-40 nM).

A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM), less potently antagonizes glucosylceramide synthase (IC50 = 25 nM), but only poorly inhibits other GCase isoforms; suppresses hapten-induced colitis, enhances insulin sensitivity, and induces...

An allosteric inhibitor of TPase (IC₅₀s = 44 and 67 µM for purified E. coli and human enzymes, respectively); inhibits TPase-induced angiogenesis in a CAM assay; also inhibits the binding of FGF2 to FGFR1.

A non-selective, reversible COX inhibitor. with IC₅₀ values for human recombinant COX-1 and -2 at 2.6 and 1.53 µM, respectively; Ki values for ovine COX-1 and -2 are both 9 µM.

A homolog of LOEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon.

Docosahexaenoyl PAF C-16 is a PAF analog which contains docosahexaenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. Docosahexaenoyl PAF C-16 can be oxidatively fragmented resulting in the production of phospholipids with PAF-like activity.

5-trans PGF2α is the more thermodynamically stable C-5 olefin isomer of PGF2α and is a common impurity in commercial lots of PGF2α. 5-trans PGF2α administered intravenously to anesthetized rabbits caused a substantial (ten-fold) increase in respiratory rate, but this...

Cayman’s Glycolysis Cell-Based Assay Kit provides a colorimetric method for detecting extracellular L-lactate, the end product of glycolysis, in cultured cells. In the assay, lactate dehydrogenase catalyzes the oxidation of lactate to pyruvate, in which the formed NADH reduces a tetrazolium...

A β-adrenergic receptor agonist with potent positive inotropic effects in vivo; strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions; strongly increases cardiac contractility.

ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders. In human platelet...