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An antibacterial antibiotic that acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria; used as a selective antibiotic for resistant bacteria.
An acylcarnitine formed from carnitine conjugated to arachidonic acid; may be useful as a marker of mitochondrial dysfunction.
The prominent member of a complex family of macrocyclic lactones produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus; nematocide and insecticide activity via the potentiation of glutamate and GABA-gated chloride-channel opening.
An internal standard for the quantification of LTC4 by GC- or LC-MS.
A racemic version of a sterol-derived hormone that binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.
Source: recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 41.4 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a...
A competitive HDAC inhibitor that inhibits HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM); causes cell differentiation, cell cycle arrest, or apoptosis.
CAS Number: 903576-44-3 Synonyms: BF 2649 Molecular Formula: C17H26ClNO • HCl Formula Weight: 332.3
GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human...
A potent inducer of Oct3/4 expression and translation in human cell lines and in terminally differentiated human fibroblasts; promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.
An analog of DAG, which inhibits the activation of PKC by DAG.
Cayman’s SOD Assay is a fast and reliable assay for the measurement of SOD activity from plasma, serum, tissue homogenates, and cell lysates. SOD activity is assessed by measuring the dismutation of superoxide radicals generated by xanthine oxidase and hypoxanthine in a convenient 96-well...
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat TH Host: rabbit Cross Reactivity: (+) mouse and rat TH Applications: WB, IF (frozen sections), and IHC (frozen sections)
A ratiometric fluorescent calcium indicator that is amenable to a single excitation source, typically 349-364 nm light from an argon-ion laser; emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium.
An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM; IC50 = 9 nM) that exhibits >50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases; inhibits c-Met phosphorylation, as well as cell proliferation and cell motility, of various...
13,14-dihydro-19(R)-hydroxy PGE1 is the theoretical metabolite of 13,14-dihydro PGE1 by ω-1 hydroxylase. There are no known reports on its biosynthesis or biological activity.
A cell-permeable, reversible, ATP-competitive PKC inhibitor (IC50 = 15 nM, rat brain PKC); inhibits PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively; also inhibits Cdk2 (IC50 = 200 nM) and...
A TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively); used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone.
An internal standard for the quantification of 4(Z),7(Z),10(Z),13(Z),16(Z)-nonadecapentaenoic acid by GC- or LC-MS.
A reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme; blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of NETs in both mouse and human neutrophils.
Inhibits smooth MLCK (Ki = 0.3 µM) 10-fold more potently than its parent compound ML-9.
Pure, optically active single isomer fo flurbiprofen.
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning.