Cayman Chemical

Consists of arachidic acid with glycine attached at its carboxy terminus.

An inhibitor of PDE1 that has diverse cerebral and neurological effects in vivo; also directly inhibits IKKβ (IC₅₀ = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.

Molsidomine is a NO-releasing prodrug. Liver esterases convert molsidomine to the active metabolite, SIN-1 (half-life in plasma is 1-2 hours), which then releases NO.

A selective DDR1 inhibitor (IC₅₀ = 105 nM; EC₅₀ = 87 nM; inhibits colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARα. INDIGO’s reporter cells...

Antigen: human IGFBP5 amino acids 192-206 Host: rabbit Cross Reactivity: (+) mouse and rat IGFBP5 Application(s): WB IGFBP5 is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and...

FOG9 is formed through the conjugation of 5-oxoETE with glutathione in a 1,6 Michael addition at C-9. The biological activity of FOG9 has not been determined. However, FOG7, a 1,4-adduct formed within murine peritoneal macrophages, was found to be highly potent in stimulating eosinophil and...

A mixture of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV or LC- or GC-MS instrumentation; provided as a

A synthetic intermediate useful for pharmaceutical synthesis.

A low affinity calcium indicator (Kd = 7-26 µM) with long excitation wavelengths (400/485 nm) that is suitable for detecting elevated calcium levels associated with activation of smooth muscle, neurons, and intracellular calcium stores.

An inhibitor of Hsp70 (65% inhibition at 200 µM) that acts by blocking its ATPase activity; induces apoptosis in cancer cells (IC₅₀ = 5-7 µM); prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.

An internal standard for the quantification of dinor-OPDA by GC- or LC-MS.

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as...

A micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer; functions as a 53BP1 antagonist in cellular lysates.

TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity. One vial of this peptide may be used as a methyltransferase acceptor peptide for more than 200 reactions 15 µM.

A selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC₅₀s = 75 nM and 3.4 µM; ~90% inhibition in FRAP assay at 0.1 µM and 1 µM, respectively); inhibits the growth of EOL-1 AML cells both in vitro (EC₅₀ = 800 nM) and in a disseminated...

Antigen: recombinant human IL-33 Host: mouse, clone IL333068A Cross Reactivity: (+) human IL-33 Application(s): ELISA and WB IL-33, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis.

Derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively); the ethyl amide group increases lipid solubility, lowering the effective...

A fluorescent calcium indicator commonly used in FC and cell-based experiments to detect changes in intracellular calcium levels.

An antagonist of VEGFR1, VEGFR2, and VEGFR3 with IC₅₀ values of 77, 37, and 190 nM, respectively; less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on additional kinases; completely blocks retinal neovascularization in oxygen-induced ischemic...

Immunogen: Synthetic peptide from an internal region of human protein Host: rabbit Cross Reactivity: (+) human, mouse, and rat SREBP-2 Application(s): ICC and WB SREBP-2 is a transcription factor that plays a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty...

A positive allosteric modulator of GABAA receptors that produces anxiolytic effects by preferentially modulating GABAA receptors containing β2 or β3 subunits (EC₅₀s = 7.5 µM) over those bearing a β1 subunit (EC₅₀ > 20 µM); also binds the TSPO,...

Immunogen: Synthetic peptide from the C-terminal region of human PAF-AH Host: Rabbit Species Reactivity: (+) Human PAF-AH; (−) Mouse, guinea pig, canine, and chicken PAF-AH Application(s): WB PAF-AH converts PAF to the biologically inactive lyso-PAF. Plasma PAF-AH is highly selective for...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 48.4 kDa