Cayman Chemical

A carbohydrate found in liquid smoke flavorings that is used as a tracer of the contribution of biomass burning to total atmospheric particulate matter.

DISBAC10 is a fluorophore, which can be used in the study of cellular membrane electrical activity. In a resting polarized cell, DISBAC10 resides on the outer leaflet of the membrane where it can accept photons from excited fluorescein-labeled proteins and re-emit the photons at a higher wavelength...

An analog of PGF2α which has no unsaturation in the lower side chain; causes luteolysis in hamsters with a potency five times higher than PGF2α.

A metabolite of tryptophan that has pronounced effects on neuronal signaling; broadly antagonizes ionotopic glutamate receptors; has potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC₅₀ = 39 µM), aryl hydrocarbon receptor (EC₅₀ = 300 nM),...

A melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values = 10-27 and 158-513 nM, respectively); used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways.

A natural 3-O-galactoside of quercetin that has powerful antioxidant action through its ability to scavenge free radicals (IC₅₀s = 3.54 and 5.44 µg/ml in ABTS and DPPH assays, respectively).

A potent antimalarial compound that inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC₅₀ value of approximately 10 nM; effective against artemisinin-resistant malaria and can be used in combination therapy, particularly with...

A membrane-permeable cationic dye that is a substrate for P-gp and is rapidly exported from cells with functional P-gp; also accumulates within mitochondria and can be used to both localize mitochondria and study their properties.

A nonpurine inhibitor of xanthine oxidoreductase (Ki = 0.7 nM) that has proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

A inhibitor of Epac1 and Epac2 (IC₅₀s = 3.2 and 1.4 µM, respectively); blocks Akt phosphorylation and insulin secretion in pancreatic β cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway. PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. PPOH inhibits the...

A selective norepinephrine reuptake inhibitor (IC₅₀s = 8.2 nM) that displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or dopamine receptors (Kis = 1.1, 129, 1,400, 3,900, and >10,000 nM, respectively).

A potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM); lowers both total cholesterol and LDL cholesterol in animals and humans.

An inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC₅₀ = 3.1 µM).

A natural flavonoid.

Potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM); has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity.

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO’s reporter cells include the luciferase...

A potent, ATP-competitive inhibitor of PDK1 (IC₅₀ = 26 nM).

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3...

A synthetic intermediate useful for pharmaceutical synthesis.

An intravenous β-lactam antibiotic that is effective against Gram-positive and Gram-negative bacteria (MICs range from 0.008-0.13 µg/ml); highly resistant to degradation by β-lactamases.

A monoterpene glycoside that has analgesic and anti-inflammatory actions in mice.

A semi-synthetic with broad spectrum antibacterial properties; used as part of antibiotic cocktails known as PANTA (with polymyxin B, amphotericin B, nalidixic acid, and trimethoprim) and PANTAV (PANTA with vancomycin).

A potent, selective antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC₅₀ values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively; effective in vivo, as it resolves pulmonary edema resulting from myocardial...