Cayman Chemical

1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell...

A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC₅₀ = 8 µM) and histamine (IC₅₀ = 11 µM) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs...

An inhibitor of CTP:phosphocholine cytidylyl transferase with antimetastatic properties.

A potent inhibitor of GSK3β (IC50 = 30 nM) that induces neurogenesis in mouse embryonic stem cells.

Antigen: fusion protein amino acids 2-77 of human KCNQ4 Host: mouse, clone S43-6 Isotype: IgG1 Cross Reactivity: (+) human, mouse, and rat KCNQ4 Application(s): ICC, IP, and WB The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of...

The optically active enantiomer of fluprostenol.

A triazole fungicide that inhibits lanosterol 14α-demethylase, interfering with ergosterol biosynthesis, and blocks gibberellin biosynthesis.

A highly potent inhibitor of the tyrosine kinase activity of EGFR (IC₅₀ = 0.006 nM); inhibits EGFR activity in pancreatic cancer cell lines and induces the differentiation of rat mesenchymal stem cells.

A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED₅₀ =...

A selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.

The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase; acts as an agonist at the melatonin receptors MT1, MT2, and MT3.

An antibiotic that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481; inhibits osteoclast function and reduces osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid...

An endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA; acts on CB1 receptors with a potency and efficacy similar to that of AEA but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.

A high-affinity ligand of A-FABP/aP2 (Ki = 0.67 μM); shown to antagonize the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes; presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin Host: rabbit Cross-reactivity: (+) human β-catenin Application: WB β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in...

The nitrotyrosine affinity sorbent consists of Cayman’s nitrotyrosine monoclonal antibody conjugated to Sepharose 4B. Application(s): IP and WB The sorbent is designed for immunoprecipitation of nitrated proteins from biological samples. This is an effective way to concentrate nitrated...

An analog of AEA that exhibits weak or no binding to the human CB1 receptor (Ki >1 µM); inhibits rat glial gap junction cell-cell communication at a concentration of 50 µM.

An agonist of the group mGluR, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.

An alcoholic β-glucoside derived from willow bark that produces anti-inflammatory (including analgesic and antipyretic) effects similar to that of aspirin by non-selectively inhibiting COX-1 and COX-2 (IC₅₀s > 100 µM).

13,14-dh-15-k PGE1-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE1 by GC- or LC-mass spectrometry.

Antigen: recombinant human vaspin Host: mouse, clone VP63 Cross Reactivity: (+) human vaspin Application(s): ELISA and WB Vaspin is an insulin-sensitizing adipocytokine present in visceral and subcutaneous white adipose tissue that may regulate immune responses and inflammation and correlates with...

The prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of RARγ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively); cytotoxic various cancer cells through RAR-dependent and -independent signaling...