Cayman Chemical

The optically active enantiomer of fluprostenol.

A triazole fungicide that inhibits lanosterol 14α-demethylase, interfering with ergosterol biosynthesis, and blocks gibberellin biosynthesis.

A highly potent inhibitor of the tyrosine kinase activity of EGFR (IC₅₀ = 0.006 nM); inhibits EGFR activity in pancreatic cancer cell lines and induces the differentiation of rat mesenchymal stem cells.

A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED₅₀ =...

A selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.

The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase; acts as an agonist at the melatonin receptors MT1, MT2, and MT3.

An antibiotic that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.

A selective, irreversible inhibitor of BTK (IC₅₀ = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481; inhibits osteoclast function and reduces osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid...

An endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA; acts on CB1 receptors with a potency and efficacy similar to that of AEA but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.

A high-affinity ligand of A-FABP/aP2 (Ki = 0.67 μM); shown to antagonize the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes; presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin Host: rabbit Cross-reactivity: (+) human β-catenin Application: WB β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in...

The nitrotyrosine affinity sorbent consists of Cayman’s nitrotyrosine monoclonal antibody conjugated to Sepharose 4B. Application(s): IP and WB The sorbent is designed for immunoprecipitation of nitrated proteins from biological samples. This is an effective way to concentrate nitrated...

An analog of AEA that exhibits weak or no binding to the human CB1 receptor (Ki >1 µM); inhibits rat glial gap junction cell-cell communication at a concentration of 50 µM.

An agonist of the group mGluR, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.

An alcoholic β-glucoside derived from willow bark that produces anti-inflammatory (including analgesic and antipyretic) effects similar to that of aspirin by non-selectively inhibiting COX-1 and COX-2 (IC₅₀s > 100 µM).

13,14-dh-15-k PGE1-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE1 by GC- or LC-mass spectrometry.

Antigen: recombinant human vaspin Host: mouse, clone VP63 Cross Reactivity: (+) human vaspin Application(s): ELISA and WB Vaspin is an insulin-sensitizing adipocytokine present in visceral and subcutaneous white adipose tissue that may regulate immune responses and inflammation and correlates with...

The prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of RARγ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively); cytotoxic various cancer cells through RAR-dependent and -independent signaling...

A potent ACE inhibitor that blocks the formation of angiotensin I with an IC₅₀ value of 1.2 nM (ovine) and displays ID₅₀ values of 2.3 and 6.5 µg/kg in rat and canine, respectively.

This nuclear receptor assay system utilizes proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of the human estrogen-related receptor alpha (NR3B1). The N-terminal DNA binding domains (DBD) of the native ERRα has been substituted with that of the...

Antigen: synthetic peptides corresponding to amino acids 12-29 and 36-50 of human SMAD7 Host: rabbit Cross Reactivity: (+) human, mouse, rat, and ovine SMAD7; predicted to react with chimpanzee, canine, pufferfish, Xenopus, and zebrafish SMAD7 Application(s): WB SMAD7 is an inhibitory SMAD (I-SMAD)...

A natural ligand for the SXR (active at 0.1 to 0.5 µg/ml) and inhibitor of several CYP isoforms (IC₅₀ = 10 µg/ml for CYP2D6).

A selective, ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC₅₀ = 104 nM); demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC₅₀ = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably...

A potent, reversible inhibitor of 5-LO, in cell-free assays (IC₅₀ = 86 nM), intact neutrophils (IC₅₀ = 230 nM), and in whole blood (IC₅₀ = 830 nM); significantly reduces both LT biosynthesis and inflammatory reactions in rats subjected to carrageenan-induced...