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A non-ionic detergent used to solubilize membrane-bound proteins, to precipitate cholesterol, and to permeabilize cell membranes.
A control analog of the GSK3α/β inhibitor, BIO; displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively); AhR agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line,...
Activates L-type Ca2+ channels (EC50 = 16 nM); prolongs action potential duration and increases contractility in guinea pig atria preparations (EC50 = 49 nM).
A riboflavin analog that possesses antimicrobial activity; binds directly to FMN riboswitch aptamers (KD = ~ 100 nM), downregulating the expression of genes responsible for the synthesis and transport of riboflavin.
A selective FAK inhibitor (IC50s = 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively) that can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.
A chemokine receptor CCR2 antagonist (IC50 = 0.36 µM); inhibits the related CCR1 receptor with an IC50 value of 17.8 µM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 µM, respectively.
The major estrogen secreted by the premenopausal ovary.
A stereoisomer of CCG-1423 that more potently inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration.
A synthetic intermediate useful for pharmaceutical synthesis.
A hybrid molecule patterned after N-arachidonoyl serotonin; inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
A natural triterpenoid carboxylic acid that is known to have antioxidative, antimicrobial, anti-inflammatory, and anticancer activities; inhibits Na+/K+-ATPase activity (IC50 = 24.7 μM) and blocks NF-κB activation in various human cancer cells lines (10-100 μM), inhibiting cell...
The conjugate of phytanic acid and coenzyme A (CoA) whose metabolic oxidation proceeds by α-oxidation and decarboxylation, followed by β-oxidation.
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor γ (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRγ has been substituted with that of...
An AMPK activator that reduces the proliferation of AML cell lines (IC50s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway.
13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry.
R-(−)-Mandelic Acid is a synthetic intermediate useful for pharmaceutical synthesis.
LTE4 is produced by the action of a dipeptidase on LTD4 leaving only the cysteinyl group still attached to the fatty acid backbone. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities...
A guanosine analog with antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1 - 63.1 μM).
Sodium acetate stock solution (3 M, pH 5.2) contains a concentrated solution of filtered sodium acetate buffer.
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).
A cysmethynil analog that inhibits Icmt with an IC50 value of 0.86 μM; demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 vs. 27.4 μM, respectively) and human prostate cancer PC3 cells...
Racemic version of a CYP450 and epoxide hydrolase metabolite of arachidonic acid.
Racemic version of the epoxide produced by CYP450 metabolism of AEA.