Cayman Chemical

The major estrogen secreted by the premenopausal ovary.

A stereoisomer of CCG-1423 that more potently inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration.

A synthetic intermediate useful for pharmaceutical synthesis.

A hybrid molecule patterned after N-arachidonoyl serotonin; inhibits capsaicin-induced TRPV1 channel activation (IC₅₀ = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC₅₀ > 50 μM).

A natural triterpenoid carboxylic acid that is known to have antioxidative, antimicrobial, anti-inflammatory, and anticancer activities; inhibits Na+/K+-ATPase activity (IC50 = 24.7 μM) and blocks NF-κB activation in various human cancer cells lines (10-100 μM), inhibiting cell...

The conjugate of phytanic acid and coenzyme A (CoA) whose metabolic oxidation proceeds by α-oxidation and decarboxylation, followed by β-oxidation.

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor γ (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRγ has been substituted with that of...

An AMPK activator that reduces the proliferation of AML cell lines (IC₅₀s = 13-30 μM), triggering autophagy via the eIF2α/ATF4 signaling pathway.

13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry.

R-(−)-Mandelic Acid is a synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

LTE4 is produced by the action of a dipeptidase on LTD4 leaving only the cysteinyl group still attached to the fatty acid backbone. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities...

A guanosine analog with antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID₅₀s = 0.1 - 63.1 μM).

Sodium acetate stock solution (3 M, pH 5.2) contains a concentrated solution of filtered sodium acetate buffer.

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).

A cysmethynil analog that inhibits Icmt with an IC₅₀ value of 0.86 μM; demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.63 vs. 27.4 μM, respectively) and human prostate cancer PC3 cells...

Racemic version of a CYP450 and epoxide hydrolase metabolite of arachidonic acid.

Racemic version of the epoxide produced by CYP450 metabolism of AEA.

1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell...

A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC₅₀ = 8 µM) and histamine (IC₅₀ = 11 µM) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs...

An inhibitor of CTP:phosphocholine cytidylyl transferase with antimetastatic properties.

A potent inhibitor of GSK3β (IC50 = 30 nM) that induces neurogenesis in mouse embryonic stem cells.

Antigen: fusion protein amino acids 2-77 of human KCNQ4 Host: mouse, clone S43-6 Isotype: IgG1 Cross Reactivity: (+) human, mouse, and rat KCNQ4 Application(s): ICC, IP, and WB The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of...