Cayman Chemical

A more lipid soluble form of (+)-cloprostenol, possibly serving as a prodrug for the bioactive free acid.

An analog of GlcNAc that reversibly inhibits NCOAT (O-GlcNAcase).

A natural compound with strong antioxidant activity; potently inhibits the release of TNF-α (IC50 = 0.09 nM) and IL-4 (IC50 = 2.8 nM), as well as β-hexosaminidase and CCL2 (MCP-1) from IgE-stimulated RBL-2H3 mast cells.

An irreversible EGFR tyrosine kinase inhibitor that blocks ATP-dependent autophosphorylation of EGFR carrying the T790M mutation as well as an L858R mutation (IC₅₀ = 8 nM); effective in mouse models of lung cancer driven by EGFRT790M.

(–)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (–)-ropivacaine (Item No. 21422) by GC- or LC-MS. (–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.{33665} In vivo, (–)-ropivacaine induces complete impairment of...

A long-acting muscarinic receptor antagonist that binds equally to human muscarinic M1, M2, and M3 receptors (Kds = 0.04, 0.02, and 0.01 nM, respectively); dissociates slowly from M1 and M3 receptors, which are located on bronchial smooth muscle and submucosal glands, and more rapidly from M2...

Antigen: a portion of the NF-κB (p65) NLS Host: rabbit Cross-reactivity: (+) bovine, chimpanzee, gorilla, equine, human, monkey, and mouse NF-κB (p65) Application(s): ICC and WB p65 is a part of the NF-κB (p50/p65) heterodimer. IκB interacts with NF-κB dimers and...

A synthetic intermediate useful for pharmaceutical synthesis.

A glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci; binds to bacterial cell wall precursors, interfering with their synthesis.

An analytical reference standard categorized as a phytocannabinoid metabolite; a metabolite of ?8-THC; intended for research and forensic applications

A dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.

Source: Recombinant N-terminal GST-tagged enzyme expressed in E. coli MW: 61.9 kDa SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase.

12(S)-HpEPE is a monohydroperoxy PUFA produced by the action of 12-LO on EPA. Although the biological activities of 12(S)-HpEPE have not been well characterized, it is expected to behave similarly to 12(S)-HpETE.

Tamoxifen-d₅ contains five deuterium atoms at the 3, 3, 4, 4, and 4 positions. It is intended for use as an internal standard for the quantification of tamoxifen (Item No. 13258) by GC- or LC-MS. Tamoxifen is a selective estrogen receptor (ER) modulator, evoking tissue-dependent effects....

An acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor; demonstrates antiviral activity against herpes viruses, hepatitis B virus, and HIV in animal and clinical models of infections.

Spontaneously hypertensive rats fed a diet which includes γ-tocotrienol show significant reduction of systolic blood pressure and an increase of nitric oxide synthase activity in blood vessels. γ-Tocotrienol at 20 µM induces apoptosis of malignant sympathoadrenal (+SA) murine...

An α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria.

PGE2 p-acetamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of...

A non-ionic detergent used to solubilize membrane-bound proteins, to precipitate cholesterol, and to permeabilize cell membranes.

A control analog of the GSK3α/β inhibitor, BIO; displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC₅₀s = 92.0, 44-100, and >100 μM, respectively); AhR agonist (EC₅₀s = 20 and 93 nM for yeast and a hepatoma cell line,...

Activates L-type Ca2+ channels (EC₅₀ = 16 nM); prolongs action potential duration and increases contractility in guinea pig atria preparations (EC₅₀ = 49 nM).

A riboflavin analog that possesses antimicrobial activity; binds directly to FMN riboswitch aptamers (KD = ~ 100 nM), downregulating the expression of genes responsible for the synthesis and transport of riboflavin.

A selective FAK inhibitor (IC₅₀s = 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively) that can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.

A chemokine receptor CCR2 antagonist (IC₅₀ = 0.36 µM); inhibits the related CCR1 receptor with an IC₅₀ value of 17.8 µM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC₅₀ values of 0.13, 0.32, and 47 µM, respectively.