(–)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (–)-ropivacaine (Item No. 21422) by GC- or LC-MS. (–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.{33665} In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 µL of an 8 mM solution is injected percutaneously into the sciatic nerve.{42580} (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine (Item No. 16618).{42581} Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.
Technical Information
Formal Name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione
CAS Number
124-94-7
Synonyms
NSC 13397
Molecular Formula
C21H27FO6
Formula Weight
394.4
Purity
98%
Formulation
(Request formulation change)
A crystalline solid
Solubility
(Learn about Variance in Solubility)
DMF: 25mg/mL
DMF:PBS (pH 7.2) (1:6): 0.14mg/mL
DMSO: 15mg/mL
λmax
240 nm
SMILES
F[C@]12[C@@]([C@@](C[C@@H](O)[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(C=C[C@@]41C)=O
InChi Code
InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChi Key
GFNANZIMVAIWHM-OBYCQNJPSA-N
Shipping & Storage Information
Storage -20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
Shelf life: 4 years