Cayman Chemical

An indirect activator of AMPK (EC₅₀ = 11.7 μM); stimulates glucose uptake in L6 myocytes and promotes phosphorylation of ACC, a known target of AMPK; decreases blood glucose concentrations in Zucker diabetic rats, demonstrating its utility in whole animals; inhibits the growth of...

A selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (IC₅₀s = 14.3 and 18.7 μM, respectively); 30 mg/kg twice daily in rats attenuates pain-related behavior in models of diabetic hypersensitivity and...

A minor product from the synthesis of (±)14(15)-EE-8(Z)-E.

A reversible inhibitor of RAD51 (IC₅₀ = 44.2 µM); inhibits DNA repair and sensitizes cancer cells to cross-linking chemotherapy in vitro at 150 µM.

An endocannabinoid analog that inhibits the cellular uptake of AEA (IC50 = 2.4 µM).

The ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for AEA; binds to the rat brain CB1 receptor (Ki = 324 nM), which is approximately 10-fold higher than the Ki for AEA; inhibits shaker-related voltage-gated potassium channels in brain...

Host: mouse, clone C-11 Cross Reactivity: (+) human cytokeratins 4, 5, 6, 8, 10, 13, and 18 Application(s):FC, IF, IHC (paraffin-embedded tissue), and WB Cytokeratins make up a large family of proteins classified as intermediate filament polypeptides. They are subdivided into type I (acidic) and...

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity; used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.

A prodrug for methylprednisolone; has superior water solubility compared to the active glucocorticoid.

A analog of tenovin-1; elevates p53 activity in MCF-7 cells at 10 µM and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg.

Testosterone is the prototypic and predominant circulating androgenic steroid. It plays a major role in the growth and function of many reproductive and non-reproductive tissues and organs including muscle, liver, and brain, directing the development of the male phenotype during embryogenesis and at...

A potent inhibitor of the kinase activity of ALK2 (IC₅₀ = 13-108 nM); disrupts dorsoventral development in zebrafish; affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis; inhibits the growth of lung cancer cells, reducing tumor growth in a...

An internal standard for the quantification of minoxidil by GC- or LC-MS.

DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.

A cell-permeable, fluorescent probe for DNA (ex. 352 nm/em. max 461 nm) that is useful as a marker of nuclei for cell cycle and to distinguish nuclear morphology in apoptotic cells.

A planar biphenyldicarboxylic acid ester used as a hepatoprotectant in the treatment of chronic hepatitis; 250 µg/ml stimulates JAK/STAT signaling and induces the expression of interferon-α stimulated genes in a HepG2 cell line.

Latanoprost is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP...

An ester of the free acid that is less water soluble, but more ,amenable for the formulation of stearidonate-containing diets and dietary supplements.

A selective histamine H3 receptor antagonist that crosses the blood-brain barrier; binds to rat cerebral cortical cells in vitro with a pKi value of 8.4.

Highly selective COX-2 inhibitor (IC₅₀ 50 >500 µM (COX-1).

An antagonist of PPARα (IC50 = 240 nM), promoting the recruitment of co-repressor proteins; used in cell-free, cell lysate, and whole cell systems.

A precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base.

A 4-demethoxy analog of daunorubicin which intercalates in DNA and inhibits topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC₅₀ = 20-120 nM); effective in combination therapy for the treatment of different types of leukemia.

A fluorescent probe used for measuring membrane fluidity in artificial and living membrane systems.