Cayman Chemical

A natural neurotransmitter that is activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively); may induce either contraction or relaxation of vascular smooth muscle, depending on adrenoceptor subtype expression.

A small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein binding protein (CBP)-mediated transcription (IC₅₀ = 3 µM); selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at...

An antagonist of the histamine H1 receptor (Ki = 250 nM) with low affinity for muscarinic receptors (Ki = 3.6 nM); reduces nausea, dizziness, and motion sickness.

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC₅₀ = 8.38 µM); induces p53 mutant protein degradation via MDM2-mediated ubiquitination.

An orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively); induces rapid, reversible inhibition of capsaicin (IC₅₀ = 3 nM)-, acid (pH 5.3)-, or heat (50°C;...

13(S)-HpODE is produced by the oxidation of linoleic acid by LO-1 in many plants including soybean, flaxseed, apples, and tea leaves, and by 15-LO in mammals. In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase. In mammalian tissues, 13(S)-HpODE is generally...

Bestatin is an inhibitor of aminopeptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the aminopeptidase activity of LTA4 hydrolase with a Ki value of 201 nM. The IC₅₀ value for inhibition of LTB4 synthesis is approximately 10 µM.

An inhibitor of HDACs that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM); does not inhibit HDAC8; induces p21/CIP1/WAF1, slowing cell growth, differentiation, and tumor development in vivo.

A cell-permeable analog of FPP that potently inhibits FTase (IC₅₀ = 50-75 nM), preventing farnesylation of Ras; does not inhibit geranylgeranyl transferase at similar concentrations (IC₅₀ > 100 µM); blocks Ras-mediated transformation of NIH 3T3 cells.

Antigen: rat sEH amino acids 292-306 Host: rabbit Cross Reactivity: (+) human, mouse, and rat sEH; expected to react with bovine, canine, chicken, and porcine sEH Application: WB Soluble epoxide hydrolase (sEH) metabolizes exogenous and endogenous epoxides into corresponding diols.

An antiproliferative agent against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 and 9 µM respectively).

CAY10499 is a potent inhibitor of human HSL exhibiting an IC50 of 90 nM for the recombinant enzyme. The in vivo pharmacological efficacy of CAY10499 has not been reported.

A fluorescent indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.

A precursor to Vitamin K2 that is capable of both redox cycling and arylating nucleophilic substrates by Michael addition; used as an antihemorrhagic agent and to inhibit the proliferation of various cancer cells.

An internal standard for the quantification of Lyso-PAF C-18 by GC- or LC-MS.

A small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC₅₀ = 39 µM).

A macrocyclic antibiotic that exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC₅₀ = 221.3 nM in HL-60 cells); 1-4 μM inhibits oxidized LDL-induced accumulation of cholesteryl esters in macrophages; inhibits clathrin-coated pit-mediated endocytosis.

A saturated DAG with lauric acid (12:0) side-chains attached at both the sn-1 and sn-2 positions.

A PP1 and PP2A inhibitor with IC₅₀ values of 0.6 and 0.05 µM, respectively.

An analog of AEA that binds to the human CB1 receptor with a Ki value of 60 nM; inhibits rat glial gap junction cell-cell communication at a concentration of 50 µM.

A synthetic intermediate useful for pharmaceutical synthesis.

A stable PGE2 analog that demonstrates gastroprotective and ulcer-healing properties in rats (ID50s range from 0.06 to 0.58 μg/kg).

A ROCK-I inhibitor (IC₅₀ = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay; also inhibits ROCK-II and PRK2 with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 38.2 kDa