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A potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells; has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
A zwitterionic, long-chain acylcarnitine used to improve in vivo absorption of certain hydrophilic compounds, especially through mucosal membranes.
A broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively); potently (IC50 = receptor tyrosine kinases.
A first generation, selective SGLT inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM); 0.1 to 1.0 mg/kg increases urinary glucose excretion in both normal and diabetic rats, improves glucose tolerance in normal rats,...
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM).
An antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines.
A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively); has no activity against PAR2, PAR4, or other receptors involved in platelet...
C-8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C-8 ceramide-1-phosphate are essentially the opposite of C-8 ceramide; it induces DNA synthesis and cell division. The effects of C-8 ceramide-1-phosphate can be attenuated by...
A natural glycoinsolate found in cruciferous vegetables, including broccoli; converted to the isothiocyanate sulforaphane by the enzyme myrosinase, resulting in antioxidant, anti-inflammatory, and anti-carcinogenic effects.
A minor galactolipid present in oligodendrocytes and myelin, as well as comprises a major fraction of the lipids in photosynthesizing plants and green microorganisms; used as a marker for myelination.
Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase by a variety of stimuli such as phorbol esters, lipopolysaccharides, and...
An analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component; reduces IOP better than latanoprost in a rabbit model of glaucoma.
A cell-permeable, chromogenic substrate for β-galactosidase used in histochemical and molecular biology applications, including detection of lacZ activity in cells and tissues.
Catalase is an ubiquitous antioxidant enzyme that is present in most aerobic cells. It is involved in the detoxification of H2O2, a ROS that is a toxic product of both normal aerobic metabolism and pathogenic ROS production. Cayman’s Catalase Assay utilizes the peroxidatic function of catalase...
A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor; inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.
An estradiol analog that binds to ERα with IC50 values in the range of 22-28 nM
Antigen: synthetic peptide from human HDAC11 amino acids 182-199 Host: rabbit Cross Reactivity: (+) human, mouse, and rat HDAC11 Application(s): WB HDAC11 is a class IV HDAC that is expressed in kidney, heart, brain, skeletal muscle, and testis.
A cell-permeable inhibitor of class IIa HDACs (IC50s = 126, 80, 36, and 19 nM for HDAC4, 5, 7, and 9, respectively).
CAS Number: 474668-57-0 Molecular Formula: C18H19D9N2O Formula Weight: 297.5
CAS Number: 187960-08-3 Molecular Formula: C15H6D4O5 Formula Weight: 274.3
An L-type calcium channel antagonist.
A fluorescent probe that can react with ONOO-, HOCl, and H2O2 in a similar manner to CBA, yet is formulated for improved solubility.
The biological effects of the cysLTs, including LTC4, LTD4, and LTE4 are transduced mainly by a pair of 7-transmembrane receptors, CysLT1 and CysLT2. BAY u9773 is a non-selective antagonist of the CysLT receptors, having about the same IC50 (20-80 nM) for the inhibition of LT responses in...
A coumarin antibiotic that inhibits the ATPase activity of DNA gyrase, permitting relaxation of negative supercoils; also generates positively supercoiled DNA.