Cayman Chemical

Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml. Rosmarinic acid suppresses endotoxin-induced activation of complement and...

9β-hydroxy stereoisomer of PGF2α; much less active than PGF2α in antifertility and bronchoconstrictor activities; exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.

A hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 µM.

Specifically inhibits the histone acetyltransferase Gcn5 (IC₅₀ = 100 μM) and can inhibit pre-RNA splicing with an IC₅₀ value of 0.5 mM.

Source: Active human recombinant N-term His-tagged protein expressed in E. coli Mr: 24.3 kDa One unit of enzyme produces one µmole of PGD2/min at 25°C in 100 mM Tris-HCl buffer, pH 8.0, containing 1 mM GSH, 1 mg/ml magnesium chloride, and 40 µM PGH2

A selective, orally bioavailable EZH2 inhibitor with K_i values that are less than 3 nM for wild type and Tyr646 mutant of EZH2; demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

Synonyms Ampakine CX-516 Ampalex CX-516

A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling, particularly through disulfide linkages with cysteine residues on proteins.

Corey lactone aldehyde benzoate is a versatile, chiral intermediate used in the preparation of prostaglandins and prostaglandin analogs.

An inhibitor of CETP activity (IC₅₀ = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by blocking CTEP association with HDL.

A phospholipid containing the saturated long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

An analgesic and antipyretic prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine and 4-aminoantipyrine, which both inhibit COX activity (COX-1: IC₅₀s = 2.6 and 20.8 µM, respectively, and COX-2: IC₅₀s = 4.7 and 41.8 µM, respectively); binds...

Antigen: hamster brain SAF Host: mouse, clone SAF 83 Isotype: IgG Application(s): EIA, FC, and WB

An internal standard for the quantification of ent-8-iso-PGF2α by GC- or LC-MS.

A natural stilbenoid glycoside that is converted by glucosidases to rhapontigenin, a resveratrol analog.

A stable carbacyclic PGI2 analog of that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM;10 mg/kg (oral) or 1 mg/kg (intraduodenal) prevents thrombotic arterial occlusion.

A CoA derivative used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane; may mediate cancer cell cytotoxicity induced by fatty acid synthase inhibition.

A primary mono-oxygenation product of DHA in human whole blood, human leukocytes, and mouse brain; serves as a precursor to 17(S)-resolvins.

A sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles; selectively inhibits the growth of influenza A and B viruses in plaque reduction assays (IC₅₀s = 5-14 nM) and to directly inhibit influenza A and B virus neuraminidases...

A small molecule inhibitor that potently and selectively inhibits both HDAC6 and HDAC8 (IC₅₀s = 36 and 120 nM, respectively).

A derivative of PGF2β with increased water solubility.

Immunization of mice with chicken egg albumin (ovalbumin/OVA) in a precipitate complex with aluminum hydroxide (alum) is a highly effective means of inducing a potent TH2-mediated immune response. OVA/alum immunized mice produce anti-OVA antibodies predominantly of the IgG1 and IgE isotypes that...

A naturally-occurring tropane alkaloid that serves as an intermediate in the synthesis of a variety of bioactive alkaloids, many of which have potent neurological actions.

Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole (Item No. 14880).{61476} It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations...