Cayman Chemical

A specific antagonist of the type 4 PGE2 receptor EP4; possesses significant anti-tumor growth activity in multiple preclinical tumor models through modulating myeloid cells.

A mycotoxin from F. moniliforme, a fungus of grains; at 1 μM, inhibits sphingosine N-acyltransferase; fumonisins, found as contaminants in foods, induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity.

PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically...

L-DPPC is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. The extent of incorporation of the enzyme γ-glutamyl transpeptidase in erythrocyte membranes was five times higher when proteoliposomes were prepared from L-DPPC as compared to control....

Antigen: purified ovine COX-1 Host: mouse, clone CX111 Isotype: IgG2b Cross Reactivity: (+) ovine, bovine, human, mouse, rat, and monkey COX-1, ovine COX-2 (50%), and human COX-2 (~5%); (−) mouse COX-2 Application(s): IHC and WB Constitutively expressed COX-1 is responsible for the production...

An inhibitor of neprilysin, a zinc metallopeptidase that degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1.

A mixture of mycotoxins produced by fungi that have been found in Cannabis samples and cultivation materials; designed for use as a reference standard for these substances during routine analytical checks using HPLC-UV or LC- or GC-MS instrumentation;

A cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM); inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC₅₀ = 280 nM), preventing nuclear translocation and DNA binding.

A product of 12-LO oxidation of DGLA that inhibits agonist-mediated platelet activation (IC₅₀ = 40 µM).

A cell-permeable allosteric inhibitor of PTP1B (IC₅₀s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively); binds reversibly and non-competitively; selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the...

A mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components; demonstrates rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumonia.

A cell-permeable irreversible inhibitor of caspase-3 (IC₅₀ = 130 nM); potently inhibits apoptosis.

A 2' deoxy analog of 5-azacytidine which is incorporated into DNA and causes hypomethylation by inhibiting DNA methyltransferases in a concentration-dependent manner; useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.

A selective inhibitor of the nucleotide pool sanitizing enzyme MTH1 (IC₅₀ = 5 nM) that kills cancer cell lines (IC₅₀s = 2.48-6.37 µM); reduces tumor growth in mouse xenografts.

An inactive analog of U-73122; can be used as a negative control.

A cell permeable analog of the PKC-activating second messenger DAG.

An inhibitor of STK33.

A TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations; increases insulin effectiveness in obese NIDDM subjects; promotes adipocyte differentiation by up-regulating the expression of UCP-2.

A disulfide dimer of N-acetylcysteine with immunomodulatory and anti-atherosclerotic properties; modifies contact sensitivity/delayed hypersensitivity reactions in mice and improves endothelial function in Watanabe heritable hyperlipidemic rabbits.

The 11-dehydro TXB2 Quant-PAK has been designed for the convenient, precise quantification of 11-dehydro TXB2 by GC- or LC-MS. It includes a 50 µg vial of 11-dehydro TXB2-d4 and a precisely weighed vial of unlabeled 11-dehydro TXB2, with the precise weight (2-4 mg) indicated on the vial. This...

13,14-dihydro-15-keto PGF1α is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.

A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism; applications of this molecule include regulation of virulence, infection prevention, and septicemia in fish.

An ecdysteroid hormone produced in arthropod species that induces developmental changes associated with ecdysis and the completion of metamorphosis; used as a tool in inducible gene regulation systems controlled by reporter cells transfected with the ecdysone receptor.

A nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC50 > 5 μM).