Cayman Chemical

EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-β receptor type 1; IC₅₀ = 12.9 nM). It also inhibits ALK2 and ALK4 at nanomolar concentrations. EW-7197 blocks TGF-β/Smad signaling, cell migration, invasion, and lung metastasis in mouse...

A lipophilic analog of 17-phenoxy trinor PGF2α.

A selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC₅₀ = 0.04-0.28 µM) over BD1 (IC₅₀ = 1.8-3.1 µM), which causes selective release of BET proteins from chromatin; increases the expression of ApoA1 and reduces...

PGF2α-OMe is an analog of PGF2α in which the C-1 carboxyl group has been replaced an O-methyl ether. The compound is reported to retain ocular hypotensive properties, but the receptors which mediate this activity have not been clearly documented.

Antigen: synthetic peptide from human EP2 receptor C-terminal amino acids 335-358 Host: rabbit Cross Reactivity: (+) human, mouse, and rat EP2 receptors; (−) EP1, EP3, and EP4 receptors Application(s): ICC and WB Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase...

(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE...

An antitumor antibiotic that induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia cells at 0.2-1 μM; triggers a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK.

Antigen: human Host: rabbit Cross Reactivity: (+) fibrinogen (α chain); (-) fibrinogen (β chain), fibrinogen (γ chain) Species Reactivity: (+) human Application(s): WB

A small molecule inhibitor of MDMX.

A sesquiterpene lactone with anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 10 µM; suppresses the proliferation of cancer cells through multiple mechanisms; has antibacterial and anti-protozoal activities.

An active metabolite of proguanil, produced by CYP2C19; an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

An antihypertensive agent that blocks postsynaptic α1-adrenergic receptors in the periphery (IC₅₀ = 0.20 nM in dog aorta) and in the brain (IC₅₀ = 1.7 nM in rat brain); also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 - 12.4 nM; IC₅₀ = 7.8 nM...

Antigen: human JARID1B/PLU1 amino acids 1,534-1,544 Host: rabbit Cross Reactivity: (+) human JARID1B/PLU1 Application(s): FC and ICC

Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis....

16,16-dimethyl PGA2 is a metabolism resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 µg/ml. Daily infusion of 10 µg of 16,16-dimethyl PGA2 methyl...

A cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10.

A potent inhibitor of PDE5 (IC50 = 1-5 nM) that also blocks the activity of PDE11 (IC50 = 10-33 nM); IC50 values against other isoforms of PDE are in the micromolar range; pharmacokinetics are highlighted by its prolonged duration of effect.

A flavone that modulates xenobiotic metabolism; antagonizes AhR at nanomolar concentrations, although it agonizes AhR at higher concentrations (10 µM); inhibits CYP19, CYP1A1, CYP1A2, and CYP1B1 (IC₅₀s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4...

An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively); significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2.

CAS Number: 958293-77-1 Synonyms: DL-Naproxen-d₃ Molecular Formula: C₁₄H₁₁D₃O₃ Formula Weight: 233.3

A natural analog of resveratrol with antioxidant and anti-cancer activity; a mechanism-based, selective inactivator of CYP450 1A1 (IC₅₀ = 400 nM); inhibits the proliferation of cancer cell lines (IC₅₀ = 48 μM).

An analog of suramin that selectively inhibits P2X1 receptors (pIC50 = 6.3); selectively antagonizes the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to...

A synthetic prodrug which is converted to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo; suppresses the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; supports bone growth; provides renal and cardiovascular protection during chronic kidney...

One of two cyclic forms of D-glucose that is the monomer unit in cellulose.