Cayman Chemical

A FAHFA in which oleic acid is esterified to 10-hydroxy stearic acid.

A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.

An internal standard for the quantification of MitoP, the end product of a mitochondrial matrix H2O2 probe reaction, by GC- or LC-MS.

An NSAID commonly used in veterinary medicine to combat pain, inflammation, and fever; blocks the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair.

Linoleic acid is a PUFA prevalent in the western diet. The peroxide free linoleic acid is protected from autoxidation by the antioxidant BHT (2,6-Di-tert-butyl-4-hydroxytoluene). Linoleic acid is also available without BHT (Item No. 90150).

An NMDA open-channel blocker (Ki = 1.2 μM at -60 mV) and uncompetitive antagonist with known anti-Parkinsonian, anti-epileptic, anti-stroke, and anti-Alzheimer’s disease properties; 12 μM blocks 90% of NMDA receptor activity and prevents NMDA-receptor mediated neurotoxicity in rat...

A pyridine regio-isomer of the JMJD3 inhibitor GSK-J4; cell-permeable and hydrolyzed to a free base, which is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal negative control molecule.

An antagonist of L-type voltage-dependent Ca2+ channels (Ki = 5.3 nM); inhibition is voltage dependent; reduces the impact of delayed ischemic neurological deficits following subarachnoid hemorrhage.

A potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM); acts as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.

A long-lasting rifamycin antibiotic that is effective against Mycobacterium species, including M. tuberculosis as well as experimental infections caused by S. aureus, S. pyogenes group A, S. pneumoniae, and K. pneumoniae.

A redox indicator used to detect cellular respiration; primarily reduced by Complex I in mitochondria and, under anaerobic conditions, is completely reduced to an insoluble red 1,3,5-triphenylformazan.

A labeling reagent that selectively reacts with azido groups on modified proteins through the Staudinger ligation reaction; can be used in common avidin-based biochemical techniques in whole cells or by blotting experiments following SDS-PAGE; has been used successfully in conjunction with Daz-1 or...

Displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains; binds BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.

A β-lactone that stimulates host defense in immune cells by inhibiting cell surface esterases, lipases, and N-formylmethionine aminopeptidases with IC₅₀ values of 0.056, 0.003, and 0.08 µg/ml, respectively; also inhibits cutinases produced by fungal pathogens, thus...

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of PGF2α. Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate...

A potent, selective, orally bioavailable inhibitor of Syk (IC₅₀ = 1 nM); blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively); inhibits inflammation and tumor growth in animal models of rheumatoid arthritis...

Peptide Sequence: human 11β-HSD1 amino acids 78-92 (CLELGAASAHYLAGT) To be used in conjunction with Cayman’s 11β-HSD1 polyclonal antibody (Catalog No. 10004303) to block protein-antibody complex formation during immunochemical analysis of 11β-HSD1.

A polyunsaturated keto acid formed by the oxidation of 5-HETE in neutrophils by a specific dehydrogenase; stimulates the increase in cytosolic calcium levels in neutrophils (EC₅₀ = 2 nM) and stimulates the migration and degranulation of eosinophils via a specific GPCR.

The predominant female-specific mating pheromone of the fruit fly D. melanogaster that elicits wing vibrations in male D. melanogaster flies at amounts above 100 ng.

Source: Recombinant protein expressed in E. coli MW: 44.5 kDa

A natural pyrazinone produced by certain fungi and by Staphylococcus spp. that inhibits calpain in a casein hydrolysis assay (IC₅₀ = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.

LDL uptake and its regulation are important therapeutic targets for atherosclerosis and related diseases. Cayman Chemical’s LDL Uptake Cell-Based Assay employs a preparation of human LDL conjugated to Dylight™ 550 as a fluorescent probe for detection of LDL uptake into cultured cells. A...

A mixture of neutral, non-acid, forms of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV or LC- or GC-MS ins

An analog of cAMP that super-activates Epacs (AC₅₀ = 1.8 µM), dissociating GDP from Rap1 more strongly than the natural Epac agonist, cAMP; strongly selective for EPac over PKA.