Cayman Chemical

A cell permeable inhibitor of PRMTs; inhibits both yeast Hmt1p and human PRMT1 (IC₅₀ = 3.0 and 8.8 μM, respectively); also effectively blocks the activity of PRMTs 3, 4, and 6 but not that of lysine methyltransferases; inhibits HIV-1 reverse transcriptase (IC₅₀ = 5.0 μM).

Keystone essential fatty acid that is converted by COX, LO, and epoxygenase enzymes into more than 150 potent metabolites in species ranging from fungi to plants to mammals.

MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.

A second generation milbemycin with potent endectocide activity; commonly used as an anthelmintic drug in veterinary applications.

An imidazobenzodiazepine derivative that competitively inhibits benzodiazepine binding to GABAA receptors (IC₅₀ = 2 nM); used to reverse sedation induced by benzodiazepine drugs and is effective in the treatment of benzodiazepine overdose or withdrawal.

An inhibitor of CaM, inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC₅₀ = 0.15 and 0.35 µM, respectively); also inhibits an array of calcium-transporting ATPases (IC₅₀ = 2.1 and 2.9 µM,...

A potent, selective G9a and GLP HMTase inhibitor (IC50s = MB231 cells (IC50 = 81 nM) and demonstrates favorable separation of functional and toxic effects.

12-epi Leukotriene B4-d4 (12-epi LTB4-d4) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 12-epi LTB4 by GC- or LC-mass spectrometry.

ω-3 Fatty acids, represented primarily by DHA, EPA, and α-linoleate, are essential dietary nutrients required for normal growth and development. ω-3 Arachidonic acid methyl ester is a neutral, lipid-soluble form of the rare fatty acid ω-3 arachidonic acid. The ω-3 fatty...

Source: Active recombinant N-terminal proprietary tagged protein expressed in E. coli UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3.

A modified nucleoside generated by the processing of tRNA by methyltransferases; urinary and serum levels are elevated in several forms of cancer, supporting its use as a biomarker.

A stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 μM for A1, A2A, A2B, and A3 receptors, respectively); modulates neurotransmission release and blocks seizures by activating adenosine receptors.

An orally bioavailable inhibitor of class I PI3K isoforms, potently blocking, in vitro, both p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM); much less effectively inhibits the class III PI3K Vps34 and mTOR and has no effect on PI4Kβ and several other kinases; inhibits tumor growth in...

11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). Boswellic acids are specific, non-redox inhibitors of leukotriene synthesis via 5-lipoxygenase that demonstrate anti-inflammatory and...

Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.

A potent inhibitor of specific IAPs that binds baculovirus IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively); induces activation of caspases, decreasing the viability of cancer cells without affecting normal...

A pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis and activates stress-activated protein kinase, MAPK, and other signal transduction pathways.

An aminooxy analog of ornithine that irreversibly inhibits aminotransferases, including ornithine aminotransferase (Ki = 2 µM); cytotoxic to a range of organisms.

A GRP/bombesin receptor 2 antagonist (IC₅₀ = 4.13 nM in vitro); reduces bombesin-stimulated pancreatic amylase secretion and attenuates bombesin-stimulated increases in blood pressure in rats.

A competitive antagonist of the nucleotide receptor P2X7 (pIC₅₀ = 6.9); inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors; used to evaluate the role of P2X7 in nociception, oxidative stress, and apoptosis in cells...

Peptide Sequence: CB1 receptor (C-Term) amino acids 461-472 To be used in conjunction with Cayman’s CB1 Receptor (C-Term) polyclonal antibody (Item No. 10006590) to block protein-antibody complex formation during immunochemical analysis of CB1

A major phase I metabolite of the mycotoxin α-zearalanol (zeranol), a non-steroidal estrogen produced by fungi; an estrogen receptor agonist (EC₅₀ = 0.11 µM).

A dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin; demonstrates cytostatic activity in various mouse models of human tumors, including glioblastomas, prostate carcinoma, pancreatic,...

A central component of energy storage, metabolism, and signal transduction in vivo; a precursor for ATP and agonist of purinergic receptors.