Cayman Chemical

Risdiplam is a survival of motor neuron-2 (SMN2) splicing modifier.{50413} It enhances SMN2 splicing (EC1.5x = 40 nM) and increases SMN protein levels (EC1.5x = 163 nM) in cellular assays. Risdiplam (3 mg/kg) increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model...

A DHA metabolite derived via epoxidation of the 16,17-double bond; epoxygenase metabolites of DHA have been detected in a mouse model of inflammation.

A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.

A cell-permeable inhibitor of SIRT1 (IC₅₀ = 56 µM) and SIRT2 (IC₅₀ = 59 µM); less effectively inhibits SIRT5 (IC₅₀ >300 µM) and has no effect on class I and II HDACs; sensitizes H460 lung cancer cells to etoposide and paclitaxel; blocks a...

An inhibitor of brassinosteroid biosynthesis that at 1 µM can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress.

The major active lignin in fruits of the burdock plant A. lappa that demonstrates potent antiviral, anti-inflammatory, and antiproliferative activity.

A hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively.

A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC₅₀s = 4, 32, and 24 µM, respectively); prevents the formation of actin filament comet tails by Listeria in infected SKOV3 cells...

A fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC₅₀ = 126 µg/ml) and topoisomerase IV (IC₅₀ = 26.5 µg/ml); used to enhance the production of microRNAs with tumor suppressor functions to generate...

A metabolite of LTB4 in human neutrophils; inhibits LTB4-induced degranulation of human neutrophilis (Ki = 13.3 nM).

A member of the family of fatty N-acyl ethanolamines collectively called anandamides and the most abundant of several fatty acid ethanolamides produced by the PLD hydrolysis of mouse neuroblastoma cell membrane phospholipids; its specific role in the cannabinergic system remains to be elucidated.

A dual modulator of p53-MDM2 interaction and NF-κB signaling; binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53; inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65; inhibits cancer cell growth in vitro and in vivo.

An inhibitor of topoisomerase I that demonstrates less toxicity than its parent compound; demonstrates strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).

A potent, non-ATP-competitive inhibitor of Plk1 (IC₅₀ = 9 nM); induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM); active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents.

A mixture of proteolytic enzymes derived from the stem and fruit of pineapple plants; studied for a number of potential beneficial effects including anti-inflammatory, anti-thrombotic, fibrinolytic, and anti-cancer functions.

An active principle of P. amarus that has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.

A natural alkaloid mycotoxin that blocks activation of the HIV LTR by TNF-α in HeLa cells (IC₅₀ = 5 µM); inhibits virus production in OM-10.1 cells (HL-60 promyelocytes infected with HIV-1) treated with TNF-α (IC₅₀ = 2.5 µM).

A selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC₅₀ = 1.5 μM); blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.

Inhibits calcium/calmodulin-dependent phosphodiesterase from bovine brain, presumably PDE1 (IC₅₀ = 15 mM).

An orally bioavailable, specific, broad spectrum JAK inhibitor (IC₅₀s = 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and JAK4, respectively); blocks cell-based JAK signaling induced by IL-2, IL-4, IL-6, IL-13, or IL-31 with IC₅₀ values ranging from 36 to 249 nM.

Immunogen: peptide from the N-terminal region of mouse IP receptor Host: mouse Species Reactivity: (+) mouse IP receptor Application(s): WB

A competitive sPLA2-IIA inhibitor with IC₅₀ values of 80, 30, 120, 110, 520, >1600, and >1600 nM for sPLA2-hGIIA, -mGIIA, -rGIIA, -hGV, -mGV, -hGX, and -mGX, respectively; ameliorates local inflammatory responses in TPA-induced mouse ear edema at 45 µg/ear or 11 mg/kg i.v.

A non-nucleoside pyridopyrimidine compound that selectively blocks the action of adenosine kinase in an adenosine-competitive manner (IC₅₀ = 1.7 nM in cell-free assays); suppresses nociception in various rodent pain models.

An irreversible inhibitor of fatty acid synthase (FAS); causes cytoxicity and apoptosis in human cancer cell lines; causes weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.