Cayman Chemical

One of the AHSLs frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa and/or strains of the B. cepacia complex.

A phytocannabinoid that has been isolated from Lebanese hashish

A selective, cell-permeable EZH2 inhibitor (IC₅₀ = 4 nM) that has been shown to inhibit the trimethylation of H3K27 in HCC1806 cells with an IC₅₀ value of 174 nM.

An orally active Ras inhibitor with selectivity for H-Ras (Ki = 46 μM); inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC₅₀ = ~1.5 μM); exhibits antitumor activity in mice bearing a xenograft of human colon...

A ROCK-I and II inhibitor (IC₅₀s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase; suppresses the activation of ROCK substrates MLC-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 at 100 nM in cancer cells.

A synthetic steroid used occasionally to treat endometriosis; binds to androgen, and progesterone receptors with EC50 values of approximately 20 and 30 nM, respectively.

An internal standard for the quantification of ALA by GC- or LC-MS.

Mn(III)TBAP is a cell-permeable SOD mimic. At a concentration of 30 µM, it decreases the doubling time of SOD-null E. coli. by 2-fold.

A small molecule that suppresses transactivation of survivin through direct binding to its promoter; induces apoptosis in p53-deficient cancer cells in vitro at 10 nM with little effect on expression levels of other IAP- or Bcl-2-related proteins.

A negatively charged phospholipid containing a PA head group and 18:0 fatty acids at the sn-1 and sn-2 positions of the glycerol backbone; used to study the dynamics of model lipid bilayers.

3-keto Petromyzonol is a synthetic intermediate useful for pharmaceutical synthesis.

Antigen: human caspase-3 amino acids 166-183 Host: rabbit Cross Reactivity: (+) human, mouse, baboon, and hamster caspase-3; recognizes both the proform and active subunits of caspase-3 Application(s): WB and IHC Caspase-3 is a key effector caspase in the apoptosis cascade and is efficiently...

A broadly applicable antiparasitic compound that demonstrates IC₅₀ values of 2.5 and 10 µM for Giardia and Cryptosporidium, respectively; kills replicating and nonreplicating M. tuberculosis with an IC₅₀ value of 1 µM, while seemingly evading the development of...

A positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM), activates ERK1/2 phosphorylation (EC50 = 248 nM), and potentiates glutamate-induced cAMP production (EC50 = 21.5 μM).

HQL-79 is a selective inhibitor of hematopoietic PGD synthase. Structurally, it is a synthetic tetrazole compound originally prepared as a possible antihistamine. Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 is orally available, and inhibits the synthesis of PGD2...

A neutral, more lipophilic form of the free acid.

FK3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID). FK3311 inhibits LPS-induced thromboxane B₂ (TxB₂; Item No. 19030) production (IC₅₀ = 316 nM) in vitro and inhibits...

A natural sesquiterpene with anti-cancer and anti-inflammatory actions.

An anti-migraine agent.

An HDAC inhibitor.

Antigen: human, mouse, and rat amino acids 22-36 Host: rabbit Cross Reactivity: (+) human, mouse, rat, ovine, and porcine PPARa; (−) PPARg Application(s): WB PPARa is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.

The inactive metabolite of vitamin K1 formed during blood clotting that is rapidly reduced back to vitamin K1 by a microsomal epoxide reductase.

14(Z)-Eicosenoic acid is a monounsaturated fatty acid. It is found in small quantities in marine life including the sponge (Tedania dirhaphis) and goldfish (Carassius auratus). Potentially it could be the product of fatty acid chain elongation of 12(Z)-oleic acid.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human glucocorticoid receptor (NR3C1), a ligand-dependent transcription factor, commonly referred to as GR. INDIGO’s reporter cells...