Cayman Chemical

A DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis.

An inactive control probe (IC₅₀ > 10 µM) for KC01 (Item No. 17364), the potent inhibitor of ABHD16A.

The inactive 7(S) epimer of Maresin 1; useful as an experimental negative control.

A potent and selective CB1 receptor inverse agonist (Ki = 243 nM; EC50 = 195 nM); a 10 µM concentration results in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and CB2 receptors, respectively.

An anti-inflammatory steroid.

Human HDAC8 is a class I HDAC and has been identified in a variety of human cancer tissues. Cayman’s HDAC8 Inhibitor Screening Assay provides a convenient fluorescence-based method for screening HDAC8 inhibitors. The procedure requires only two easy steps, both performed in the same...

A relatively selective inhibitor of iNOS, exhibiting IC₅₀ values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively; effectively inhibits iNOS both in vitro and in vivo.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor alpha (NR2B1), a ligand-dependent transcription factor commonly referred to as RXRA or RXRα. INDIGO’s reporter cells include...

PPHP is a substrate for the measurement of peroxidase enzymes. PPHP has been used to quantitate the peroxidase activity of COX-1 and COX-2.

(+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist. The 15(R)-epimers of most PGs are about 100 times less potent...

ALT is a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Cayman’s Alanine Transaminase Assay provides a convenient method of detecting ALT activity in serum, plasma, tissue samples, and...

An oxindole compound that potently blocks Syk activity (IC₅₀ = 5 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC₅₀ = 1.4 μM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change.

Antigen: synthetic peptide corresponding to human IRAK-1 amino acids 700-712 Host: rabbit Cross Reactivity: (+) human and mouse IRAK-1; (−) IRAK-2 Application(s): IP and WB IRAK-1 is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling...

Peptide Sequence: rat lysoPLD amino acids 573-588 To be used in conjunction with Cayman’s lysoPLD polyclonal antibody (Catalog No. 10005375) to block protein-antibody complex formation during immunochemical analysis of lysoPLD

A thiophene carboximide derivative proposed to inhibit IKK2; likely to be useful in the treatment of inflammatory diseases and cancer.

An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively); alters hemodynamic properties, including hypertension, in animals.

A closed form of tetranor-PGDM whose formation in biological samples has not been evaluated.

A mixture of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV or LC- or GC-MS instrumentation; provided as a

A cell-permeable, selective SIRT1 inhibitor (IC₅₀ = 0.7-2 µM) that reactivates p53 by inhibiting SIRT1 deacetylation activity; inhibits cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC₅₀s = 5.4, 51.9, 3.2, 33.9, and 85.4 µM...

A hypocholesterolemic compound that promotes the degradation of HMG-CoA reductase in various animal models; human and rabbit pregnane X receptor agonist (Kd = 41 nM; EC₅₀ = 137 nM for hPXR in vitro) that can induce CYP3A expression in human and rabbit hepatocytes.

A lipid soluble, esterified prodrug of AL 8810.

A pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC₅₀ values are 230, 340, 435, 445, 855, and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C, respectively); inhibits Jumonji demethylase activity, alters gene expression, and blocks viability of cancer...

An orally bioavailable inhibitor of HDAC1, HDAC3, and HDAC6 (IC₅₀s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells; abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC₅₀s = 2.5-3 µM); dose-dependently...

A serotonin synthesis inhibitor that is used for tracing pools of neuronal serotonin, as a competitive inhibitor of tryptophan binding to albumin, and as a substrate for the serotonin neural transporter.