Cayman Chemical

PGI2 is an unstable COX metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC₅₀ value of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...

Promotes the reprogramming of human somatic cells to pluripotent stem cells; increases the number of human foreskin fibroblasts that express alkaline phosphatase when used at 10 μM with four standard reprogramming factors; down-regulates inducers of cellular senescence and inhibits Dnmt1 and...

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 µM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly...

An aminocyclitol antibiotic active against Gram-negative and Gram-positive bacteria; inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation.

A toxin that is used to study Gi/o-linked GPCR signaling in cells and EAE in animals; completely blocks the ability of AC to be inhibited by GPCRs that signal through Gi subunits.

Antigen: human GPR31 N-terminal amino acids Host: rabbit Cross Reactivity: (+) human GPR31 Application(s): ELISA, FC, and IF

An analog of bimatoprost.

A dual agonist of PPARα and PPARγ that enhances the binding and transcriptional activity of PPARα and PPARγ in AC2F cells (5 µM) and reduces serum glucose, triglyceride, and insulin levels in db/db mice (3 mg/kg).

A potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals.

Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding...

LHW090-A7 is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce...

The inactive enantiomer of L-NMMA used as a control compound to explore non-specific effects of L-NMMA.

An LSD1 inhibitor.

A selective inhibitor of MNK1 in vitro (IC₅₀ = 2.2 μM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases; blocks the phosphorylation of eIF4E in response to TNF-α, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC₅₀ = 3...

Corticosterone is a glucocorticoid produced by the adrenal cortex in response to ACTH (adrenocorticotropic hormone), and is the precursor to aldosterone. The production of glucorcorticoids is increased by stress; therefore, corticosterone can be used as a biomarker of stress. Plasma corticosterone...

A natural isothiocyanate which induces the expression of phase II detoxification enzymes and activates Nrf2, promoting the expression of antioxidant and phase II genes; acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth...

A selective PDK1 inhibitor (IC₅₀ = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members; suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well...

A form of chitobiose containing eight acetate groups.

A metabolite of the immunosuppressant drug cyclosporin A that displays about 10% lower immunosuppressant activity than cyclosporin A; used as an internal standard for the quantification of cyclosporin A.

A fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.

An internal standard for the quantification of SAG by GC- or LC-MS.

A cell-permeable chemical probe that reacts specifically with sulfenic acid-modified proteins; this probe is less sensitive for sulfenic acid detection compared to its analog DAz-2 (Item No. 13382).

An potent, selective inhibitor of cellular mTOR activity (EC₅₀ = 0.3 nM) with more than 800-fold selectivity for mTOR over PI3K (EC₅₀ = 200 nM) and improved bioavailability compared to Torin 1.

An analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications