Cayman Chemical

A more stable form of (±)11(12)-EET used for long-term storage.

A phenylalkylamine calcimimetic that facilitates the activation of CaSR, a GPCR that triggers PI-intracellular Ca2+ signaling; stimulates PI hydrolysis and proliferation through human CaSR (pEC₅₀ values are 6.9 and 7.4, respectively) in the presence of calcium.

An asymmetric phospholipid that can interdigitate with equal length (symmetric) acyl chain phospholipids in bilayer membranes to potentially minimize the hydrophobic mismatch between acyl chains.

A natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension.

Source: Recombinant protein expressed in E. coli Mr: 25.2 kDa

A macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken (Ki or IC₅₀ = 173, 500, 260, and 120 μM, respectively); also inhibits MDH1 (cytoplasmic) and MDH2 (mitochondrial) (IC₅₀s = 1.3 and 0.065 mM, respectively).

A selective, cell-permeable inhibitor of the BAZ2 family of bromodomain containing proteins (IC₅₀s = 9-350 nM in a BAZ2B AlphaScreen; KDs = 0.26 and 0.14 µM, for BAZ2A and BAZ2B respectively).

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2. When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the...

CAS Number: 1173020-43-3 Synonyms: LY110140-d₅ Molecular Formula: C₁₇H₁₃D₅F₃NO • HCl Formula Weight: 350.8

A potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions; relaxes rat aorta rings (ED₅₀ = 19.3 μM) and has been used as a vasodilator in the treatment of hypertensio

An intermediate in the dissociated (or type II) fatty acid biosynthesis that occurs in bacteria; generated following the reaction of hexadecenoyl-ACP with malonyl-ACP by the enzyme β-ketoacyl-ACP synthase II (EC 2.3.1.179), which produces 3-oxo octadecenoyl-ACP.

An internal standard for the quantification of estrone by GC- or LC-MS.

A fluorescent probe which is commonly used to stain DNA and chromosomes for fluorescent microscopy and flow cytometry applications; characterized by ultraviolet (max 358 nm) excitation and blue (max 461 nm) emission wavelengths.

A panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions; improves the effectiveness of chemotherapeutic agents by decreasing the expression of Multidrug Resistance Protein 1 and inhibiting P-glycoprotein.

A CPT1 and CPT2 inhibitor that inhibits rat heart and liver CPT1 (IC₅₀ = 77 and 148 µM, respectively), and rat heart CPT2 (IC₅₀ = 79 µM); inhibits mTORC1 signaling and induces autophagy in MCF-7 cells at low µM levels.

A branched chain primary alcohol with antimicrobial effects.

Peptide Sequence: human CB2 receptor sequence amino acids 20-33 (NPMKDYMILSGPQK) To be used in conjunction with Cayman’s CB2 receptor polyclonal antibody (Catalog No. 101550) to block protein-antibody complex formation during analysis for the CB2 receptor. The CB2 receptor is localized...

A potent inhibitor of human PDGFRβ (IC₅₀ = 80 nM).

A polyphenol and hydrolyzable tannin that inhibits squalene epoxidase (IC50 = 4.0 µM), a key enzyme in cholesterol synthesis; has various anti-inflammatory and anti-cancer effects.

A synthetic analog of PGF2β.

Reactive oxygen species, such as hydrogen peroxide (H2O2) and superoxide are generated by phagocytes and participate in damaging invading miccroorganisms or other biologic targets.{29448} Cayman's H2O2 Cell-Based Assay Kit provides a simple fluorometric method for the sensitive quantitation of...

An internal standard for the quantification of 2,3-dinor-6-keto PGF1α by GC- or LC-MS.

A CYP450 metabolite of estradiol with low affinity for estrogen receptors; rapidly metabolized to 2-ME2 with a half-life of approximately ten minutes in rat.

A potent and selective inhibitor of O-GlcNAcase (Ki = 21 nM); increases cellular O-GlcNAc-modified protein levels (EC50 = 30 nM) and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200 mg/kg/day); is orally bioavailable and effectively cross the blood brain barrier.