Cayman Chemical

2-Pyrimidineacetic acid is a synthetic intermediate useful for pharmaceutical synthesis.

A potential metabolite of bimatoprost when administered to animals; potential minor impurity in commercial preparations of bimatoprost.

A modified purine that is commonly found in genomes of prokaryotes, protists, and plants.

A potent inhibitor of COX-1 and COX-2 (IC₅₀s = 1.9 and 27 nM, respectively), whereas the (R)-enantiomer is 100 to 1,000 times less potent.

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000...

Antigen: synthetic peptide corresponding to human histone H4 amino acids 15-30 Host: rabbit Cross-Reactivity: (+) Human histone H4 Application(s): WB Histone H4 is a structural component of the nucleosome and is subject to covalent modification including acetylation and methylation, which may alter...

A potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anti-cancer agents when used in in vivo combination studies; inhibits PI3K isoforms and mutants with low nanomolar IC50 values; directly blocks cell...

Antigen: recombinant human Nampt Host: mouse, clone OMNI 379 Cross Reactivity: (+) human, mouse, and rat Nampt Application(s): ELISA, FC, ICC, IHC, IP, and WB Nampt is an adipokine involved in the biosynthesis of NAD+ and is highly expressed in visceral fat. It promotes vascular smooth muscle cell...

An inhibitor of HDAC, including HDAC1 (IC₅₀ = 0.1-0.2 μM); induces growth suppression and cell death of certain types of cancer cells in culture.

An esterified version of GLA which is less water soluble but more amenable for the formulation of GLA-containing diets.

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation; inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 µM.

Represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin; potency at VR1 appears equivalent to capsaicin.

A heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM); blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells.

A selective ALK1 and ALK2 inhibitor (IC₅₀s = 24 nM for each) with preference over ALK3 (IC₅₀ = 1.17 µM) and other related activin and TGF-β type I receptors (IC₅₀s = 3, 0.1, and 16 µM for ALK5, BMP6, and TGF-β, respectively).

An insect hormone used as an inducer of ecdysone-inducible mammalian expression systems.

A potent and selective β1-adrenergic receptor blocker (Ki = 47 nM for the β1 receptor, compared with 3.0 and 10 μM for the β2 and β3 receptors, respectively); predominantly metabolized by CYP2D6, an enzyme with significant genetic heterogeneity in function; has diverse...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 76.5 kDa

Potassium Phosphate Stock Solution (500 mM, pH 6.0) contains filtered potassium phosphate (500 mM, pH 6.0). It is ready to use as supplied.

An internal standard for the quantification of latanoprost ethyl amide by GC- or LC-MS.

A calmodulin inhibitor that disrupts the activity of calmodulin-dependent enzymes such as myosin light chain kinase (IC₅₀ = 8 µM) and phosphodiesterase 1A (IC₅₀ = 0.53 µM); inhibits P-glycoprotein activity in purified primary cultured rat brain microvessel...

13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(S)-HODE cholesteryl ester can be used as a standard for...

A natural plant pigment which induces the release of nitric oxide by vascular endothelium, causing vasorelaxation; inhibits signaling through EGFRs, suppressing the expression of ERα and inducing both apoptosis and autophagy at a dose of 1-40 μM; inhibits the HAT activities of p300/CBP...