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A selective inhibitor of p38 MAPK (IC50 = 89 nM)
An affinity probe that allows progesterone to be detected or immobilized using the biotin ligand.
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1)...
A non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM); increases intracellular calcium, leading to cell activation, histamine release, and increased cell proliferation; has anti-inflammatory and anti-cancer effects in...
An ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively; demonstrates higher ER agonist activity at ERα compared to ERβ (EC50 = 66 and 330 nM, respectively).
A calcium indicator that is UV light-excitable; spectral properties in the presence of low calcium concentrations (excitation max = 362 nm, emission max = 512 nm) differ from those during high calcium conditions (excitation max = 335 nm, emission max = 505 nm).
An inhibitor of ferroptosis induced in MEFs by Gpx4 deletion (IC50 = 22 nM) or by the ferroptosis inducers BSO, erastin, and RSL3; does not interfere with apoptosis, necroptosis, or necrosis; effectively suppresses ferroptosis in vivo when administered intraperitoneally.
Preferred phospholipid substrate for cPLA2; an important source of activation-induced arachidonate released as a substrate for COX-2 mediated signaling.
A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity.
A modulator of PCSK9 action that blocks LDLR degradation, increasing the uptake of LDL by liver cells in vitro; lowers cholesterol levels in mice that are fed a high fat diet.
An orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 (KDs = 1.8 and 3.1 µM, respectively); at 50 mg/kg, activates AMPK and PPARα pathways and reduces insulin resistance and glucose intolerance in wild type mice fed a high-fat diet as well as in genetically obese...
A stable, selective, and slowly reversible inhibitor of choline acetyltransferase (IC50 = 9 μM); commonly used in cells in culture.
An inhibitor of the cyclin-dependent kinases Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (Kis = 1-3 nM); inhibits tumor cell proliferation (IC50s ≤ 0.6 µM in vitro), inducing cell cycle arrest and apoptosis as well as reducing phosphorylation of the retinoblastoma protein.
A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively); also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).
A racemic version of an epoxide produced by CYP450 metabolism of AEA.
A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism; applications for this molecule include regulation of virulence and exoproteases.
A selective and potent activator of PPARα with an EC50 value of 100 nM; induces satiety, decreases food-intake, reduces body weight, and lowers plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.
A bioactive lipid produced by the sequential metabolism of anandamide by COX enzymes and PGD synthase; inactive against recombinant prostanoid receptors, including DP; increases the frequency of miniature inhibitory postsynaptic currents in hippocampal neurons; induces apoptosis in colorectal...
Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...
A dual orexin 1 and 2 receptor antagonist (Kds = 1.3 and 0.17 nM, respectively); 100 mg/kg promotes nonrapid eye movement sleep and exacerbates cataplexy in a mouse model of narcolepsy.
HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC50 values of 0.33...
A toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
An internal standard for the quantification of PGF1α by GC- or LC-MS.
An analytical reference standard categorized as a resorcinol; has been found in Cannabis vape cartridges; intended for research and forensic applications